Factores de virulencia de Mycobacterium tuberculosis

Mycobacterium tuberculosis, the etiological agent of human tuberculosis, causes annually three million deaths and latently infects about two billion people. Immunodeficiency caused by malnutrition, senescence or co-infection with HIVenhances the risk of developing active tuberculosis, either from a...

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Autor principal:	Maulén,Nancy P
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2011
Materias:	Etiology Mycobacterium tuberculosis Virulence Pathophysiology
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872011001200012
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spelling	oai:scielo:S0034-988720110012000122012-03-07Factores de virulencia de Mycobacterium tuberculosisMaulén,Nancy P Etiology Mycobacterium tuberculosis Virulence Pathophysiology Mycobacterium tuberculosis, the etiological agent of human tuberculosis, causes annually three million deaths and latently infects about two billion people. Immunodeficiency caused by malnutrition, senescence or co-infection with HIVenhances the risk of developing active tuberculosis, either from a primary infection or by reactivation of a latent infection. The increasing appearance of multidrug-resistant strains to existing drugs is worrisome, since it leaves patients practically without treatment options. The understanding of the mechanisms of transmission, pathogenesis and virulence of M. tuberculosis is important. The analysis of its genome shows the presence of alternative sigma factors, transcriptional repressors and activators, two component signaling systems, metabolic enzymes and cellular secretory systems, that are associated with virulence in a series of pathogenic micro-organisms. Environmental stimuli such as pH, temperature, osmolality, oxygen availability are processed, activating or repressing virulence genes. The molecular mechanisms of action of these genes have been elucidated in in vitro and in vivo models.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.139 n.12 20112011-12-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872011001200012es10.4067/S0034-98872011001200012
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Etiology Mycobacterium tuberculosis Virulence Pathophysiology
spellingShingle	Etiology Mycobacterium tuberculosis Virulence Pathophysiology Maulén,Nancy P Factores de virulencia de Mycobacterium tuberculosis
description	Mycobacterium tuberculosis, the etiological agent of human tuberculosis, causes annually three million deaths and latently infects about two billion people. Immunodeficiency caused by malnutrition, senescence or co-infection with HIVenhances the risk of developing active tuberculosis, either from a primary infection or by reactivation of a latent infection. The increasing appearance of multidrug-resistant strains to existing drugs is worrisome, since it leaves patients practically without treatment options. The understanding of the mechanisms of transmission, pathogenesis and virulence of M. tuberculosis is important. The analysis of its genome shows the presence of alternative sigma factors, transcriptional repressors and activators, two component signaling systems, metabolic enzymes and cellular secretory systems, that are associated with virulence in a series of pathogenic micro-organisms. Environmental stimuli such as pH, temperature, osmolality, oxygen availability are processed, activating or repressing virulence genes. The molecular mechanisms of action of these genes have been elucidated in in vitro and in vivo models.
author	Maulén,Nancy P
author_facet	Maulén,Nancy P
author_sort	Maulén,Nancy P
title	Factores de virulencia de Mycobacterium tuberculosis
title_short	Factores de virulencia de Mycobacterium tuberculosis
title_full	Factores de virulencia de Mycobacterium tuberculosis
title_fullStr	Factores de virulencia de Mycobacterium tuberculosis
title_full_unstemmed	Factores de virulencia de Mycobacterium tuberculosis
title_sort	factores de virulencia de mycobacterium tuberculosis
publisher	Sociedad Médica de Santiago
publishDate	2011
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872011001200012
work_keys_str_mv	AT maulennancyp factoresdevirulenciademycobacteriumtuberculosis
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Factores de virulencia de Mycobacterium tuberculosis

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