Trasplante hepático en cirrosis por virus B: profilaxis con gammaglobulina antiHBs en dosis a "demanda"

Infection recurrence rates among hepatitis B virus infected liver allograft recipients, may be as high as 80%. Immunoprophylaxis with anti HBVgammaglobulin may reduce these rates and improve survival. The dose of anti HBV gammaglobulin that must be used is not clearly defined. The most commonly acce...

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Autores principales:	Poniachik,Jaime, Pizarro,Carolina, Contreras,Jorge, Silva,Javier, Hurtado,Carmen, Venegas,Mauricio, Castillo,Jaime, Cardemil,Gonzalo, Oksenberg,Danny, Ibarra,José, Bórquez,Angélica, Díaz,Juan Carlos
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2012
Materias:	Hepatitis B virus Immunoglobulins Lamivudine
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872012000100011
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id	oai:scielo:S0034-98872012000100011
record_format	dspace
spelling	oai:scielo:S0034-988720120001000112012-04-12Trasplante hepático en cirrosis por virus B: profilaxis con gammaglobulina antiHBs en dosis a "demanda"Poniachik,JaimePizarro,CarolinaContreras,JorgeSilva,JavierHurtado,CarmenVenegas,MauricioCastillo,JaimeCardemil,GonzaloOksenberg,DannyIbarra,JoséBórquez,AngélicaDíaz,Juan Carlos Hepatitis B virus Immunoglobulins Lamivudine Infection recurrence rates among hepatitis B virus infected liver allograft recipients, may be as high as 80%. Immunoprophylaxis with anti HBVgammaglobulin may reduce these rates and improve survival. The dose of anti HBV gammaglobulin that must be used is not clearly defined. The most commonly accepted protocol uses 10,000 units during the anhepatic phase and 10,000 units daily during one week, followed by weekly doses of 10,000 units during one month and maintenance with 10,000 units monthly, without measuring anti hepatitis B surface antigen antibodies (antiHBs). Some reports recommend the use of immunoglobulin on demand, to maintain antiHBs titers between 100 and 250 U/l. The infection recurrence rates among patients treated with immunoglobulin and Lamivudine fluctuates between 0 and 10%, during follow up periods of 13 to 30 months. We report three liver allograft recipients that received immunoglobulin on demand, using a mean of41,000 units, maintaining adequate antiHBs titers.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.140 n.1 20122012-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872012000100011es10.4067/S0034-98872012000100011
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Hepatitis B virus Immunoglobulins Lamivudine
spellingShingle	Hepatitis B virus Immunoglobulins Lamivudine Poniachik,Jaime Pizarro,Carolina Contreras,Jorge Silva,Javier Hurtado,Carmen Venegas,Mauricio Castillo,Jaime Cardemil,Gonzalo Oksenberg,Danny Ibarra,José Bórquez,Angélica Díaz,Juan Carlos Trasplante hepático en cirrosis por virus B: profilaxis con gammaglobulina antiHBs en dosis a "demanda"
description	Infection recurrence rates among hepatitis B virus infected liver allograft recipients, may be as high as 80%. Immunoprophylaxis with anti HBVgammaglobulin may reduce these rates and improve survival. The dose of anti HBV gammaglobulin that must be used is not clearly defined. The most commonly accepted protocol uses 10,000 units during the anhepatic phase and 10,000 units daily during one week, followed by weekly doses of 10,000 units during one month and maintenance with 10,000 units monthly, without measuring anti hepatitis B surface antigen antibodies (antiHBs). Some reports recommend the use of immunoglobulin on demand, to maintain antiHBs titers between 100 and 250 U/l. The infection recurrence rates among patients treated with immunoglobulin and Lamivudine fluctuates between 0 and 10%, during follow up periods of 13 to 30 months. We report three liver allograft recipients that received immunoglobulin on demand, using a mean of41,000 units, maintaining adequate antiHBs titers.
author	Poniachik,Jaime Pizarro,Carolina Contreras,Jorge Silva,Javier Hurtado,Carmen Venegas,Mauricio Castillo,Jaime Cardemil,Gonzalo Oksenberg,Danny Ibarra,José Bórquez,Angélica Díaz,Juan Carlos
author_facet	Poniachik,Jaime Pizarro,Carolina Contreras,Jorge Silva,Javier Hurtado,Carmen Venegas,Mauricio Castillo,Jaime Cardemil,Gonzalo Oksenberg,Danny Ibarra,José Bórquez,Angélica Díaz,Juan Carlos
author_sort	Poniachik,Jaime
title	Trasplante hepático en cirrosis por virus B: profilaxis con gammaglobulina antiHBs en dosis a "demanda"
title_short	Trasplante hepático en cirrosis por virus B: profilaxis con gammaglobulina antiHBs en dosis a "demanda"
title_full	Trasplante hepático en cirrosis por virus B: profilaxis con gammaglobulina antiHBs en dosis a "demanda"
title_fullStr	Trasplante hepático en cirrosis por virus B: profilaxis con gammaglobulina antiHBs en dosis a "demanda"
title_full_unstemmed	Trasplante hepático en cirrosis por virus B: profilaxis con gammaglobulina antiHBs en dosis a "demanda"
title_sort	trasplante hepático en cirrosis por virus b: profilaxis con gammaglobulina antihbs en dosis a "demanda"
publisher	Sociedad Médica de Santiago
publishDate	2012
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872012000100011
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Trasplante hepático en cirrosis por virus B: profilaxis con gammaglobulina antiHBs en dosis a "demanda"

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