Linfoma marginal del bazo asociado a acidosis láctica tipo B: Caso clínico

Lactic acidosis in the absence of hypoxia or tissue hypoperfusion (type B) is very rare and is associated with the use of some drugs or malignancy. We report a 79-year-old woman, with a marginal non-Hodgkin's lymphoma of the spleen that was subjected to a splenectomy one year ago. She presented...

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Autores principales:	Vega,Jorge, Rodríguez,María de los Ángeles, Peña,Armando, Vásquez,Alejadro
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2012
Materias:	Acidosis, lactic Antibodies, monoclonal murine-derived Lymphoma non-Hodgkin Rituximab
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872012000200014
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spelling	oai:scielo:S0034-988720120002000142013-04-11Linfoma marginal del bazo asociado a acidosis láctica tipo B: Caso clínicoVega,JorgeRodríguez,María de los ÁngelesPeña,ArmandoVásquez,Alejadro Acidosis, lactic Antibodies, monoclonal murine-derived Lymphoma non-Hodgkin Rituximab Lactic acidosis in the absence of hypoxia or tissue hypoperfusion (type B) is very rare and is associated with the use of some drugs or malignancy. We report a 79-year-old woman, with a marginal non-Hodgkin's lymphoma of the spleen that was subjected to a splenectomy one year ago. She presented with unexplained tachypnea associated with pancytopenia and elevation of IgM to 10 times over the higher normal limit. Laboratory tests showed the presence of metabolic acidosis and high lactic acid levels in the absence of infection, tissue hypoxia or hypoperfusion. She was treated with sodium bicarbonate and steroids without obtaining a reduction in lactate levels. Twelve days after admission, a single dose of Rituximab quickly normalized lactate concentrations and platelet count. After the fourth dose of Rituximab, pancytopenia disappeared and IgM fell to 25% of its baseline concentration.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.140 n.2 20122012-02-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872012000200014es10.4067/S0034-98872012000200014
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Acidosis, lactic Antibodies, monoclonal murine-derived Lymphoma non-Hodgkin Rituximab
spellingShingle	Acidosis, lactic Antibodies, monoclonal murine-derived Lymphoma non-Hodgkin Rituximab Vega,Jorge Rodríguez,María de los Ángeles Peña,Armando Vásquez,Alejadro Linfoma marginal del bazo asociado a acidosis láctica tipo B: Caso clínico
description	Lactic acidosis in the absence of hypoxia or tissue hypoperfusion (type B) is very rare and is associated with the use of some drugs or malignancy. We report a 79-year-old woman, with a marginal non-Hodgkin's lymphoma of the spleen that was subjected to a splenectomy one year ago. She presented with unexplained tachypnea associated with pancytopenia and elevation of IgM to 10 times over the higher normal limit. Laboratory tests showed the presence of metabolic acidosis and high lactic acid levels in the absence of infection, tissue hypoxia or hypoperfusion. She was treated with sodium bicarbonate and steroids without obtaining a reduction in lactate levels. Twelve days after admission, a single dose of Rituximab quickly normalized lactate concentrations and platelet count. After the fourth dose of Rituximab, pancytopenia disappeared and IgM fell to 25% of its baseline concentration.
author	Vega,Jorge Rodríguez,María de los Ángeles Peña,Armando Vásquez,Alejadro
author_facet	Vega,Jorge Rodríguez,María de los Ángeles Peña,Armando Vásquez,Alejadro
author_sort	Vega,Jorge
title	Linfoma marginal del bazo asociado a acidosis láctica tipo B: Caso clínico
title_short	Linfoma marginal del bazo asociado a acidosis láctica tipo B: Caso clínico
title_full	Linfoma marginal del bazo asociado a acidosis láctica tipo B: Caso clínico
title_fullStr	Linfoma marginal del bazo asociado a acidosis láctica tipo B: Caso clínico
title_full_unstemmed	Linfoma marginal del bazo asociado a acidosis láctica tipo B: Caso clínico
title_sort	linfoma marginal del bazo asociado a acidosis láctica tipo b: caso clínico
publisher	Sociedad Médica de Santiago
publishDate	2012
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872012000200014
work_keys_str_mv	AT vegajorge linfomamarginaldelbazoasociadoaacidosislacticatipobcasoclinico AT rodriguezmariadelosangeles linfomamarginaldelbazoasociadoaacidosislacticatipobcasoclinico AT penaarmando linfomamarginaldelbazoasociadoaacidosislacticatipobcasoclinico AT vasquezalejadro linfomamarginaldelbazoasociadoaacidosislacticatipobcasoclinico
_version_	1718436613125570560

Linfoma marginal del bazo asociado a acidosis láctica tipo B: Caso clínico

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