Linfoma relacionado a infección por virus de la inmunodeficiencia humana en un hospital público de Santiago, Chile

Linfoma relacionado a infección por virus de la inmunodeficiencia humana en un hospital público de Santiago, Chile

Background: Cancer is the third cause of death in patients infected with human immunodeficiency virus (HIV) and lymphoma is the most common type. Aim: To describe the clinical characteristics, histology, risk factors and prognosis of these patients, in a Chilean public hospital in Chile. Material an...

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Autores principales: Cabrera,María Elena, Silva,Guillermo, Soto,Andrés, Roselló,Rodrigo, Castro,Constanza, Martínez,Virginia, Ballesteros,Juan, Blamey,Rodrigo, Garreaud,Claudia
Lenguaje:Spanish / Castilian
Publicado: Sociedad Médica de Santiago 2012
Materias:
Antiretroviral therapy, highly active
HIV
Hodgkin disease
Lymphoma, non-Hodgkin
Acceso en línea:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872012000200015
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spelling oai:scielo:S0034-988720120002000152013-04-11Linfoma relacionado a infección por virus de la inmunodeficiencia humana en un hospital público de Santiago, ChileCabrera,María ElenaSilva,GuillermoSoto,AndrésRoselló,RodrigoCastro,ConstanzaMartínez,VirginiaBallesteros,JuanBlamey,RodrigoGarreaud,Claudia Antiretroviral therapy, highly active HIV Hodgkin disease Lymphoma, non-Hodgkin Background: Cancer is the third cause of death in patients infected with human immunodeficiency virus (HIV) and lymphoma is the most common type. Aim: To describe the clinical characteristics, histology, risk factors and prognosis of these patients, in a Chilean public hospital in Chile. Material and Methods: Records of 55 patients (45 males) aged between 23 and 67years with lymphoma and HIV positive serology, diagnosed between 1992-2008, were reviewed. Results: Six patients (11%) had Hodgkin lymphoma (HL) and the rest, non-Hodgkin lymphoma (NHL). B-cell phenotype constituted 83.7% of NHL cases. The most common subtypes of all the lymphoma were diffuse large B cell lymphoma in 24 cases (43.6%), Burkitt lym-phoma in 12 cases (21.8%), andplasmablastic lymphoma in 5 cases (9.1%). Thirty five patients (64%) underwent curative intended chemotherapy (CT) concomitantly with highly active antiretroviral therapy (HAART). Three year survival of the whole cohort was 27%. By multivariate analysis, the most important prognostic factors for long term survival, were complete responses to CT, (p < 0.01) and a low international prognostic index (IPI) score for NHL, (p = 0.01). HAART, histologic subtype and CD4 lymphocyte count at diagnosis, did not influence survival. Conclusions: The most important prognostic factors for HIV patients with lymphoma, were achieving CR with CT and low IPI score. Prognosis remains poor, even with HAART therapy.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.140 n.2 20122012-02-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872012000200015es10.4067/S0034-98872012000200015
institution Scielo Chile
collection Scielo Chile
language Spanish / Castilian
topic Antiretroviral therapy, highly active
HIV
Hodgkin disease
Lymphoma, non-Hodgkin
spellingShingle Antiretroviral therapy, highly active
HIV
Hodgkin disease
Lymphoma, non-Hodgkin
Cabrera,María Elena
Silva,Guillermo
Soto,Andrés
Roselló,Rodrigo
Castro,Constanza
Martínez,Virginia
Ballesteros,Juan
Blamey,Rodrigo
Garreaud,Claudia
Linfoma relacionado a infección por virus de la inmunodeficiencia humana en un hospital público de Santiago, Chile
description Background: Cancer is the third cause of death in patients infected with human immunodeficiency virus (HIV) and lymphoma is the most common type. Aim: To describe the clinical characteristics, histology, risk factors and prognosis of these patients, in a Chilean public hospital in Chile. Material and Methods: Records of 55 patients (45 males) aged between 23 and 67years with lymphoma and HIV positive serology, diagnosed between 1992-2008, were reviewed. Results: Six patients (11%) had Hodgkin lymphoma (HL) and the rest, non-Hodgkin lymphoma (NHL). B-cell phenotype constituted 83.7% of NHL cases. The most common subtypes of all the lymphoma were diffuse large B cell lymphoma in 24 cases (43.6%), Burkitt lym-phoma in 12 cases (21.8%), andplasmablastic lymphoma in 5 cases (9.1%). Thirty five patients (64%) underwent curative intended chemotherapy (CT) concomitantly with highly active antiretroviral therapy (HAART). Three year survival of the whole cohort was 27%. By multivariate analysis, the most important prognostic factors for long term survival, were complete responses to CT, (p < 0.01) and a low international prognostic index (IPI) score for NHL, (p = 0.01). HAART, histologic subtype and CD4 lymphocyte count at diagnosis, did not influence survival. Conclusions: The most important prognostic factors for HIV patients with lymphoma, were achieving CR with CT and low IPI score. Prognosis remains poor, even with HAART therapy.
author Cabrera,María Elena
Silva,Guillermo
Soto,Andrés
Roselló,Rodrigo
Castro,Constanza
Martínez,Virginia
Ballesteros,Juan
Blamey,Rodrigo
Garreaud,Claudia
author_facet Cabrera,María Elena
Silva,Guillermo
Soto,Andrés
Roselló,Rodrigo
Castro,Constanza
Martínez,Virginia
Ballesteros,Juan
Blamey,Rodrigo
Garreaud,Claudia
author_sort Cabrera,María Elena
title Linfoma relacionado a infección por virus de la inmunodeficiencia humana en un hospital público de Santiago, Chile
title_short Linfoma relacionado a infección por virus de la inmunodeficiencia humana en un hospital público de Santiago, Chile
title_full Linfoma relacionado a infección por virus de la inmunodeficiencia humana en un hospital público de Santiago, Chile
title_fullStr Linfoma relacionado a infección por virus de la inmunodeficiencia humana en un hospital público de Santiago, Chile
title_full_unstemmed Linfoma relacionado a infección por virus de la inmunodeficiencia humana en un hospital público de Santiago, Chile
title_sort linfoma relacionado a infección por virus de la inmunodeficiencia humana en un hospital público de santiago, chile
publisher Sociedad Médica de Santiago
publishDate 2012
url http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872012000200015
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