Folatos y riesgo de cáncer de mama: revisión sistemática

An increased folate intake may be beneficial in deficient populations. However, in women with adequate levels it may not deliver additional benefits while it may increase the risk for some forms of cancer. A systematic literature review of benefits or risks of folate in the development of breast can...

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Autores principales:	Castillo-L,Cecilia, Tur,Josep A, Uauy,Ricardo
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2012
Materias:	Breast neoplasms Folic acid Review
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872012000200016
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spelling	oai:scielo:S0034-988720120002000162013-04-11Folatos y riesgo de cáncer de mama: revisión sistemáticaCastillo-L,CeciliaTur,Josep AUauy,Ricardo Breast neoplasms Folic acid Review An increased folate intake may be beneficial in deficient populations. However, in women with adequate levels it may not deliver additional benefits while it may increase the risk for some forms of cancer. A systematic literature review of benefits or risks of folate in the development of breast cancer was performed using MEDLINE, systematic review of selected articles and references of the selected articles looking specifically at serum folate levels, dietary folate intake or total folate intake and the risk of developing breast cancer. Fourteen case-control studies, fourteen cohort studies, seven case-control nested studies, two randomized trials and two meta-analyses were selected for analysis based on pre-established criteria. The reviewed evidence does not support the hypothesis that higher intakes of dietary folate reduce the risk for breast cancer. Some studies showed a higher risk of breast cancer in populations exposed to high folate intake post fortification, especially when folic acid is used. The results support the need to be cautious and to limit the exposure of women to high intakes of folic acid, especially in countries with mandatory food fortification.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.140 n.2 20122012-02-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872012000200016es10.4067/S0034-98872012000200016
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Breast neoplasms Folic acid Review
spellingShingle	Breast neoplasms Folic acid Review Castillo-L,Cecilia Tur,Josep A Uauy,Ricardo Folatos y riesgo de cáncer de mama: revisión sistemática
description	An increased folate intake may be beneficial in deficient populations. However, in women with adequate levels it may not deliver additional benefits while it may increase the risk for some forms of cancer. A systematic literature review of benefits or risks of folate in the development of breast cancer was performed using MEDLINE, systematic review of selected articles and references of the selected articles looking specifically at serum folate levels, dietary folate intake or total folate intake and the risk of developing breast cancer. Fourteen case-control studies, fourteen cohort studies, seven case-control nested studies, two randomized trials and two meta-analyses were selected for analysis based on pre-established criteria. The reviewed evidence does not support the hypothesis that higher intakes of dietary folate reduce the risk for breast cancer. Some studies showed a higher risk of breast cancer in populations exposed to high folate intake post fortification, especially when folic acid is used. The results support the need to be cautious and to limit the exposure of women to high intakes of folic acid, especially in countries with mandatory food fortification.
author	Castillo-L,Cecilia Tur,Josep A Uauy,Ricardo
author_facet	Castillo-L,Cecilia Tur,Josep A Uauy,Ricardo
author_sort	Castillo-L,Cecilia
title	Folatos y riesgo de cáncer de mama: revisión sistemática
title_short	Folatos y riesgo de cáncer de mama: revisión sistemática
title_full	Folatos y riesgo de cáncer de mama: revisión sistemática
title_fullStr	Folatos y riesgo de cáncer de mama: revisión sistemática
title_full_unstemmed	Folatos y riesgo de cáncer de mama: revisión sistemática
title_sort	folatos y riesgo de cáncer de mama: revisión sistemática
publisher	Sociedad Médica de Santiago
publishDate	2012
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872012000200016
work_keys_str_mv	AT castillolcecilia folatosyriesgodecancerdemamarevisionsistematica AT turjosepa folatosyriesgodecancerdemamarevisionsistematica AT uauyricardo folatosyriesgodecancerdemamarevisionsistematica
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Folatos y riesgo de cáncer de mama: revisión sistemática

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