Caracterización de la ingestión por sobredosis de paracetamol: Reporte de un centro de información toxicológica chileno

Background: Paracetamol (acetaminophen) is an analgesic and antipyretic drug widely used across the world. Its ingestion is one of the most common causes of drug overdose. In the United States is the first cause of acute hepatitis in adults. Aim: To describe the epidemiological profile of paracetamo...

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Autores principales:	Bravo,Victoria, Román,Matías, Bettini,Marli, Cerda,Patricia, Mieres,Juan José, Paris,Enrique, Ríos,Juan Carlos
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2012
Materias:	Acetaminophen Epidemiology Poisoning Poison control centers Suicide
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872012000300005
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spelling	oai:scielo:S0034-988720120003000052012-05-31Caracterización de la ingestión por sobredosis de paracetamol: Reporte de un centro de información toxicológica chilenoBravo,VictoriaRomán,MatíasBettini,MarliCerda,PatriciaMieres,Juan JoséParis,EnriqueRíos,Juan Carlos Acetaminophen Epidemiology Poisoning Poison control centers Suicide Background: Paracetamol (acetaminophen) is an analgesic and antipyretic drug widely used across the world. Its ingestion is one of the most common causes of drug overdose. In the United States is the first cause of acute hepatitis in adults. Aim: To describe the epidemiological profile of paracetamol overdose in Chile. Material and Methods: Cross sectional retrospective study that included all the phone call inquiries received at the Poison Control Center of the Pontificia Universidad Catolica de Chile (CITUC) during 2009. Results: Nine hundred fifty nine inquiries involving acute paracetamol exposures were received. Women represented a 63.1% of the cases. Half of the cases were suicide attempts, of which 74.8% were women. Accidental exposures occurred mainly in children. In 29.3% of the patients, the exposure was considered to involve a hepatotoxic dose. Women had 2.7 times the risk of men to ingest a toxic dose of paracetamol with suicidal purpose (Odds ratio (OR) = 2.7; 95% confidence interval (Cl): 2.1-3.6; p < 0.001). Adolescents had 3.4 times the risk of the general consultants (OR: 3.4; 95% Cl: 2.4-4.7; p < 0.001). Conclusions: Paracetamol overdose is common in Chile. Authorities should carry out preventive measures. Antidotes and the capacity to measure plasma levels of paracetamol should be available in healthcare centers.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.140 n.3 20122012-03-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872012000300005es10.4067/S0034-98872012000300005
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Acetaminophen Epidemiology Poisoning Poison control centers Suicide
spellingShingle	Acetaminophen Epidemiology Poisoning Poison control centers Suicide Bravo,Victoria Román,Matías Bettini,Marli Cerda,Patricia Mieres,Juan José Paris,Enrique Ríos,Juan Carlos Caracterización de la ingestión por sobredosis de paracetamol: Reporte de un centro de información toxicológica chileno
description	Background: Paracetamol (acetaminophen) is an analgesic and antipyretic drug widely used across the world. Its ingestion is one of the most common causes of drug overdose. In the United States is the first cause of acute hepatitis in adults. Aim: To describe the epidemiological profile of paracetamol overdose in Chile. Material and Methods: Cross sectional retrospective study that included all the phone call inquiries received at the Poison Control Center of the Pontificia Universidad Catolica de Chile (CITUC) during 2009. Results: Nine hundred fifty nine inquiries involving acute paracetamol exposures were received. Women represented a 63.1% of the cases. Half of the cases were suicide attempts, of which 74.8% were women. Accidental exposures occurred mainly in children. In 29.3% of the patients, the exposure was considered to involve a hepatotoxic dose. Women had 2.7 times the risk of men to ingest a toxic dose of paracetamol with suicidal purpose (Odds ratio (OR) = 2.7; 95% confidence interval (Cl): 2.1-3.6; p < 0.001). Adolescents had 3.4 times the risk of the general consultants (OR: 3.4; 95% Cl: 2.4-4.7; p < 0.001). Conclusions: Paracetamol overdose is common in Chile. Authorities should carry out preventive measures. Antidotes and the capacity to measure plasma levels of paracetamol should be available in healthcare centers.
author	Bravo,Victoria Román,Matías Bettini,Marli Cerda,Patricia Mieres,Juan José Paris,Enrique Ríos,Juan Carlos
author_facet	Bravo,Victoria Román,Matías Bettini,Marli Cerda,Patricia Mieres,Juan José Paris,Enrique Ríos,Juan Carlos
author_sort	Bravo,Victoria
title	Caracterización de la ingestión por sobredosis de paracetamol: Reporte de un centro de información toxicológica chileno
title_short	Caracterización de la ingestión por sobredosis de paracetamol: Reporte de un centro de información toxicológica chileno
title_full	Caracterización de la ingestión por sobredosis de paracetamol: Reporte de un centro de información toxicológica chileno
title_fullStr	Caracterización de la ingestión por sobredosis de paracetamol: Reporte de un centro de información toxicológica chileno
title_full_unstemmed	Caracterización de la ingestión por sobredosis de paracetamol: Reporte de un centro de información toxicológica chileno
title_sort	caracterización de la ingestión por sobredosis de paracetamol: reporte de un centro de información toxicológica chileno
publisher	Sociedad Médica de Santiago
publishDate	2012
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872012000300005
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Caracterización de la ingestión por sobredosis de paracetamol: Reporte de un centro de información toxicológica chileno

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