Lipasa endotelial y su relación con la enfermedad cardiovascular y diabetes mellitus tipo 2

Endothelial lipase (EL) is synthetized by endothelial cells and its main substrates are lipoprotein phospholipids. Over expression of EL reduces high density lipoprotein (HDL) cholesterol and phospholipids, in vivo and in vitro. Inhibition of the enzyme achieves the opposite effects. The synthesis o...

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Autores principales:	Pierart Z,Camila, Serrano L,Valentina
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2012
Materias:	Atherosclerosis Cytokines Lipase
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872012000300015
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spelling	oai:scielo:S0034-988720120003000152012-05-31Lipasa endotelial y su relación con la enfermedad cardiovascular y diabetes mellitus tipo 2Pierart Z,CamilaSerrano L,Valentina Atherosclerosis Cytokines Lipase Endothelial lipase (EL) is synthetized by endothelial cells and its main substrates are lipoprotein phospholipids. Over expression of EL reduces high density lipoprotein (HDL) cholesterol and phospholipids, in vivo and in vitro. Inhibition of the enzyme achieves the opposite effects. The synthesis of the enzyme is regulated by interleukin 1 and tumor necrosis factor a. These inflammatory cytokines play a role in diabetes and vascular disease. An increase in vascular mechanical forces, that play a role in atherogenesis, also increase the synthesis of EL. There is expression of EL in endothelial cells, macrophages and muscle cells of atherosclerotic lesions of coronary arteries of humans. This evidence leads to the suspicion that EL plays a role in atherogenesis. There are also higher plasma levels of EL in subjects with type 2 diabetes, who are especially susceptible to the development of vascular lesions. Therefore the inhibition of EL could play an important role in HDL metabolism and could be a new therapeutic strategy for the prevention of atherosclerosis.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.140 n.3 20122012-03-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872012000300015es10.4067/S0034-98872012000300015
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Atherosclerosis Cytokines Lipase
spellingShingle	Atherosclerosis Cytokines Lipase Pierart Z,Camila Serrano L,Valentina Lipasa endotelial y su relación con la enfermedad cardiovascular y diabetes mellitus tipo 2
description	Endothelial lipase (EL) is synthetized by endothelial cells and its main substrates are lipoprotein phospholipids. Over expression of EL reduces high density lipoprotein (HDL) cholesterol and phospholipids, in vivo and in vitro. Inhibition of the enzyme achieves the opposite effects. The synthesis of the enzyme is regulated by interleukin 1 and tumor necrosis factor a. These inflammatory cytokines play a role in diabetes and vascular disease. An increase in vascular mechanical forces, that play a role in atherogenesis, also increase the synthesis of EL. There is expression of EL in endothelial cells, macrophages and muscle cells of atherosclerotic lesions of coronary arteries of humans. This evidence leads to the suspicion that EL plays a role in atherogenesis. There are also higher plasma levels of EL in subjects with type 2 diabetes, who are especially susceptible to the development of vascular lesions. Therefore the inhibition of EL could play an important role in HDL metabolism and could be a new therapeutic strategy for the prevention of atherosclerosis.
author	Pierart Z,Camila Serrano L,Valentina
author_facet	Pierart Z,Camila Serrano L,Valentina
author_sort	Pierart Z,Camila
title	Lipasa endotelial y su relación con la enfermedad cardiovascular y diabetes mellitus tipo 2
title_short	Lipasa endotelial y su relación con la enfermedad cardiovascular y diabetes mellitus tipo 2
title_full	Lipasa endotelial y su relación con la enfermedad cardiovascular y diabetes mellitus tipo 2
title_fullStr	Lipasa endotelial y su relación con la enfermedad cardiovascular y diabetes mellitus tipo 2
title_full_unstemmed	Lipasa endotelial y su relación con la enfermedad cardiovascular y diabetes mellitus tipo 2
title_sort	lipasa endotelial y su relación con la enfermedad cardiovascular y diabetes mellitus tipo 2
publisher	Sociedad Médica de Santiago
publishDate	2012
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872012000300015
work_keys_str_mv	AT pierartzcamila lipasaendotelialysurelacionconlaenfermedadcardiovascularydiabetesmellitustipo2 AT serranolvalentina lipasaendotelialysurelacionconlaenfermedadcardiovascularydiabetesmellitustipo2
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Lipasa endotelial y su relación con la enfermedad cardiovascular y diabetes mellitus tipo 2

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