Isoflavonas de soya y salud humana: cáncer de mama y sincronización de la pubertad

Background: Accumulated exposure to high levels of estrogen is associated with an increased incidence of breast cancer. Thus, factors such as early puberty, late menopause and hormone replacement therapy are considered to be risk factors, whereas early childbirth, breastfeeding and puberty at a late...

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Autores principales:	Valladares,Luis, Garrido,Argelia, Sierralta,Walter
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2012
Materias:	Breast neoplasms Isoflavones Phytoestrogens Puberty
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872012000400014
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spelling	oai:scielo:S0034-988720120004000142013-11-06Isoflavonas de soya y salud humana: cáncer de mama y sincronización de la pubertadValladares,LuisGarrido,ArgeliaSierralta,Walter Breast neoplasms Isoflavones Phytoestrogens Puberty Background: Accumulated exposure to high levels of estrogen is associated with an increased incidence of breast cancer. Thus, factors such as early puberty, late menopause and hormone replacement therapy are considered to be risk factors, whereas early childbirth, breastfeeding and puberty at a later age are known to consistently decrease the lifetime breast cancer risk. Epidemiological studies suggest that consumption of isoflavones correlates with a lower incidence of breast cancer. Data from human intervention studies show that the effects of isoflavones on early breast cancer markers differ between pre- and post-menopausal women. The reports from experimental animals (rats and mice) on mammary tumors are variable. These results taken together with heterogeneous outcomes of human interventions, have led to a controversy surrounding the intake of isoflavones to reduce breast cancer risk. This review summarizes recent studies and analyzes factors that could explain the variability of results. In mammary tissue, from the cellular endocrine viewpoint, we analyze the effect of isoflavones on the estrogen receptor and their capacity to act as agonists or antagonists. On the issue of puberty timing, we analyze the mechanisms by which girls, but not boys, with higher prepuberal isoflavone intakes appear to enter puberty at a later age.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.140 n.4 20122012-04-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872012000400014es10.4067/S0034-98872012000400014
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Breast neoplasms Isoflavones Phytoestrogens Puberty
spellingShingle	Breast neoplasms Isoflavones Phytoestrogens Puberty Valladares,Luis Garrido,Argelia Sierralta,Walter Isoflavonas de soya y salud humana: cáncer de mama y sincronización de la pubertad
description	Background: Accumulated exposure to high levels of estrogen is associated with an increased incidence of breast cancer. Thus, factors such as early puberty, late menopause and hormone replacement therapy are considered to be risk factors, whereas early childbirth, breastfeeding and puberty at a later age are known to consistently decrease the lifetime breast cancer risk. Epidemiological studies suggest that consumption of isoflavones correlates with a lower incidence of breast cancer. Data from human intervention studies show that the effects of isoflavones on early breast cancer markers differ between pre- and post-menopausal women. The reports from experimental animals (rats and mice) on mammary tumors are variable. These results taken together with heterogeneous outcomes of human interventions, have led to a controversy surrounding the intake of isoflavones to reduce breast cancer risk. This review summarizes recent studies and analyzes factors that could explain the variability of results. In mammary tissue, from the cellular endocrine viewpoint, we analyze the effect of isoflavones on the estrogen receptor and their capacity to act as agonists or antagonists. On the issue of puberty timing, we analyze the mechanisms by which girls, but not boys, with higher prepuberal isoflavone intakes appear to enter puberty at a later age.
author	Valladares,Luis Garrido,Argelia Sierralta,Walter
author_facet	Valladares,Luis Garrido,Argelia Sierralta,Walter
author_sort	Valladares,Luis
title	Isoflavonas de soya y salud humana: cáncer de mama y sincronización de la pubertad
title_short	Isoflavonas de soya y salud humana: cáncer de mama y sincronización de la pubertad
title_full	Isoflavonas de soya y salud humana: cáncer de mama y sincronización de la pubertad
title_fullStr	Isoflavonas de soya y salud humana: cáncer de mama y sincronización de la pubertad
title_full_unstemmed	Isoflavonas de soya y salud humana: cáncer de mama y sincronización de la pubertad
title_sort	isoflavonas de soya y salud humana: cáncer de mama y sincronización de la pubertad
publisher	Sociedad Médica de Santiago
publishDate	2012
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872012000400014
work_keys_str_mv	AT valladaresluis isoflavonasdesoyaysaludhumanacancerdemamaysincronizaciondelapubertad AT garridoargelia isoflavonasdesoyaysaludhumanacancerdemamaysincronizaciondelapubertad AT sierraltawalter isoflavonasdesoyaysaludhumanacancerdemamaysincronizaciondelapubertad
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Isoflavonas de soya y salud humana: cáncer de mama y sincronización de la pubertad

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