Proteína C Reactiva en la EPOC y su relación con la gravedad de la enfermedad, las exacerbaciones y las comorbilidades

Background: Patients with chronic obstructive pulmonary disease (COPD) have elevated serum levels of ultrasensitive C reactive protein (CRPus). This raise may be related directly to COPD and its associated systemic inflammation or secondary to other factors such as smoking status, disease severity,...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Díaz,Orlando, Parada,Alejandra, Ramos,Critóbal, Klaassen,Julieta, Díaz,Juan Carlos, Andresen,Max, Lisboa,Carmen, Saldías,Fernando
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2012
Materias:	Emphysema C-reactive protein Pulmonary disease, chronic obstructive Systemic inflammatory response syndrome
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872012000500003
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:scielo:S0034-98872012000500003
record_format	dspace
spelling	oai:scielo:S0034-988720120005000032013-11-06Proteína C Reactiva en la EPOC y su relación con la gravedad de la enfermedad, las exacerbaciones y las comorbilidadesDíaz,OrlandoParada,AlejandraRamos,CritóbalKlaassen,JulietaDíaz,Juan CarlosAndresen,MaxLisboa,CarmenSaldías,Fernando Emphysema C-reactive protein Pulmonary disease, chronic obstructive Systemic inflammatory response syndrome Background: Patients with chronic obstructive pulmonary disease (COPD) have elevated serum levels of ultrasensitive C reactive protein (CRPus). This raise may be related directly to COPD and its associated systemic inflammation or secondary to other factors such as smoking status, disease severity, acute exacerbations, or associated complications. Aim: To evaluate the potential causes of raised levels of CRPus in stable COPD patients. Patients and Methods: Cohorts of 133 mild-to-very severe COPD patients (41 current smokers), 31 never-smokers, and 33 current smoker controls were compared. Clinical assessments included body mass index (BMI), fat (FM) and fat-free mass (FFM) measurement by DEXA, forced expiratory volume in one second (FEV1), arterial oxygen tension (PaO2), six-minute walking test (SMWT), emphysema (EMPH) and right thigh muscle cross-sectional area (TMCSA), both quantified by high resolution computed tomography. Results: Serum CRPus levels were significantly higher in COPD patients than in controls (7 ± 4.2 and 3.7 ± 2.7 mg/L respectively; p < 0.0001). Being smoker did not influence CRPus levels. These levels were significantly correlated with FM (r = 0.30), BMI (r = 0.21), FEV1 (r = -0.21), number of acute exacerbations of the disease in the last year (r = 0.28), and PaO2 (r = -0.27). Using multivariate analysis FM, PaO2, and number of acute exacerbations of the disease in the last year had the strongest association with CRPus levels. Conclusions: CRPus is elevated in COPD patients, independent of smoking status. It is weakly associated with fat mass, arterial oxygen tension and frequency of exacerbations.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.140 n.5 20122012-05-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872012000500003es10.4067/S0034-98872012000500003
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Emphysema C-reactive protein Pulmonary disease, chronic obstructive Systemic inflammatory response syndrome
spellingShingle	Emphysema C-reactive protein Pulmonary disease, chronic obstructive Systemic inflammatory response syndrome Díaz,Orlando Parada,Alejandra Ramos,Critóbal Klaassen,Julieta Díaz,Juan Carlos Andresen,Max Lisboa,Carmen Saldías,Fernando Proteína C Reactiva en la EPOC y su relación con la gravedad de la enfermedad, las exacerbaciones y las comorbilidades
description	Background: Patients with chronic obstructive pulmonary disease (COPD) have elevated serum levels of ultrasensitive C reactive protein (CRPus). This raise may be related directly to COPD and its associated systemic inflammation or secondary to other factors such as smoking status, disease severity, acute exacerbations, or associated complications. Aim: To evaluate the potential causes of raised levels of CRPus in stable COPD patients. Patients and Methods: Cohorts of 133 mild-to-very severe COPD patients (41 current smokers), 31 never-smokers, and 33 current smoker controls were compared. Clinical assessments included body mass index (BMI), fat (FM) and fat-free mass (FFM) measurement by DEXA, forced expiratory volume in one second (FEV1), arterial oxygen tension (PaO2), six-minute walking test (SMWT), emphysema (EMPH) and right thigh muscle cross-sectional area (TMCSA), both quantified by high resolution computed tomography. Results: Serum CRPus levels were significantly higher in COPD patients than in controls (7 ± 4.2 and 3.7 ± 2.7 mg/L respectively; p < 0.0001). Being smoker did not influence CRPus levels. These levels were significantly correlated with FM (r = 0.30), BMI (r = 0.21), FEV1 (r = -0.21), number of acute exacerbations of the disease in the last year (r = 0.28), and PaO2 (r = -0.27). Using multivariate analysis FM, PaO2, and number of acute exacerbations of the disease in the last year had the strongest association with CRPus levels. Conclusions: CRPus is elevated in COPD patients, independent of smoking status. It is weakly associated with fat mass, arterial oxygen tension and frequency of exacerbations.
author	Díaz,Orlando Parada,Alejandra Ramos,Critóbal Klaassen,Julieta Díaz,Juan Carlos Andresen,Max Lisboa,Carmen Saldías,Fernando
author_facet	Díaz,Orlando Parada,Alejandra Ramos,Critóbal Klaassen,Julieta Díaz,Juan Carlos Andresen,Max Lisboa,Carmen Saldías,Fernando
author_sort	Díaz,Orlando
title	Proteína C Reactiva en la EPOC y su relación con la gravedad de la enfermedad, las exacerbaciones y las comorbilidades
title_short	Proteína C Reactiva en la EPOC y su relación con la gravedad de la enfermedad, las exacerbaciones y las comorbilidades
title_full	Proteína C Reactiva en la EPOC y su relación con la gravedad de la enfermedad, las exacerbaciones y las comorbilidades
title_fullStr	Proteína C Reactiva en la EPOC y su relación con la gravedad de la enfermedad, las exacerbaciones y las comorbilidades
title_full_unstemmed	Proteína C Reactiva en la EPOC y su relación con la gravedad de la enfermedad, las exacerbaciones y las comorbilidades
title_sort	proteína c reactiva en la epoc y su relación con la gravedad de la enfermedad, las exacerbaciones y las comorbilidades
publisher	Sociedad Médica de Santiago
publishDate	2012
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872012000500003
work_keys_str_mv	AT diazorlando proteinacreactivaenlaepocysurelacionconlagravedaddelaenfermedadlasexacerbacionesylascomorbilidades AT paradaalejandra proteinacreactivaenlaepocysurelacionconlagravedaddelaenfermedadlasexacerbacionesylascomorbilidades AT ramoscritobal proteinacreactivaenlaepocysurelacionconlagravedaddelaenfermedadlasexacerbacionesylascomorbilidades AT klaassenjulieta proteinacreactivaenlaepocysurelacionconlagravedaddelaenfermedadlasexacerbacionesylascomorbilidades AT diazjuancarlos proteinacreactivaenlaepocysurelacionconlagravedaddelaenfermedadlasexacerbacionesylascomorbilidades AT andresenmax proteinacreactivaenlaepocysurelacionconlagravedaddelaenfermedadlasexacerbacionesylascomorbilidades AT lisboacarmen proteinacreactivaenlaepocysurelacionconlagravedaddelaenfermedadlasexacerbacionesylascomorbilidades AT saldiasfernando proteinacreactivaenlaepocysurelacionconlagravedaddelaenfermedadlasexacerbacionesylascomorbilidades
_version_	1718436625131765760

Proteína C Reactiva en la EPOC y su relación con la gravedad de la enfermedad, las exacerbaciones y las comorbilidades

Ejemplares similares