Reversible cardiotoxicity in a 54-year-old woman treated with trastuzumab

Background: We report a 54-year-old woman with an stage IIA (T2N0M0) RE and RP negative and HER2-positive ductal invasive breast cancer who developed a reversible cardiotoxicity associated with chemotherapy. After surgery, she received four cycles of doxorubicin and cyclophosfamide. Later, she used...

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Autores principales:	Martins,Sandro José, Modesto Dos Santos,Vitorino, Thommen Teles,Ludmila, Alves Leite,Viviane
Lenguaje:	English
Publicado:	Sociedad Médica de Santiago 2012
Materias:	Breast neoplasms Chemotherapy, adjuvant drug toxicity stroke volume trastuzumab
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872012000600010
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spelling	oai:scielo:S0034-988720120006000102014-03-10Reversible cardiotoxicity in a 54-year-old woman treated with trastuzumabMartins,Sandro JoséModesto Dos Santos,VitorinoThommen Teles,LudmilaAlves Leite,Viviane Breast neoplasms Chemotherapy, adjuvant drug toxicity stroke volume trastuzumab Background: We report a 54-year-old woman with an stage IIA (T2N0M0) RE and RP negative and HER2-positive ductal invasive breast cancer who developed a reversible cardiotoxicity associated with chemotherapy. After surgery, she received four cycles of doxorubicin and cyclophosfamide. Later, she used paclitaxel and trastuzumab. At the 7th cycle of trastuzumab, she had symptoms of heart failure with left ventricle ejection fraction = 59%. Trastuzumab dosage was reduced in 25%, and heart function progressively improved. Two years after her discharge, the patient remains asymptomatic. Systolic function of the left ventricle was normal before the initial dosis of trastuzumab, but significantly worsened following the beginning of drug administration. Moreover, a clear improvement of heart function was observed soon after the daily dose of trastuzumab was reduced. Better knowledge of risk factors for cardiotoxicity related to chemotherapy, and longstanding surveillance with serial echocardiograms can avoid more severe cardiotoxicity by chemotherapy.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.140 n.6 20122012-06-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872012000600010en10.4067/S0034-98872012000600010
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Breast neoplasms Chemotherapy, adjuvant drug toxicity stroke volume trastuzumab
spellingShingle	Breast neoplasms Chemotherapy, adjuvant drug toxicity stroke volume trastuzumab Martins,Sandro José Modesto Dos Santos,Vitorino Thommen Teles,Ludmila Alves Leite,Viviane Reversible cardiotoxicity in a 54-year-old woman treated with trastuzumab
description	Background: We report a 54-year-old woman with an stage IIA (T2N0M0) RE and RP negative and HER2-positive ductal invasive breast cancer who developed a reversible cardiotoxicity associated with chemotherapy. After surgery, she received four cycles of doxorubicin and cyclophosfamide. Later, she used paclitaxel and trastuzumab. At the 7th cycle of trastuzumab, she had symptoms of heart failure with left ventricle ejection fraction = 59%. Trastuzumab dosage was reduced in 25%, and heart function progressively improved. Two years after her discharge, the patient remains asymptomatic. Systolic function of the left ventricle was normal before the initial dosis of trastuzumab, but significantly worsened following the beginning of drug administration. Moreover, a clear improvement of heart function was observed soon after the daily dose of trastuzumab was reduced. Better knowledge of risk factors for cardiotoxicity related to chemotherapy, and longstanding surveillance with serial echocardiograms can avoid more severe cardiotoxicity by chemotherapy.
author	Martins,Sandro José Modesto Dos Santos,Vitorino Thommen Teles,Ludmila Alves Leite,Viviane
author_facet	Martins,Sandro José Modesto Dos Santos,Vitorino Thommen Teles,Ludmila Alves Leite,Viviane
author_sort	Martins,Sandro José
title	Reversible cardiotoxicity in a 54-year-old woman treated with trastuzumab
title_short	Reversible cardiotoxicity in a 54-year-old woman treated with trastuzumab
title_full	Reversible cardiotoxicity in a 54-year-old woman treated with trastuzumab
title_fullStr	Reversible cardiotoxicity in a 54-year-old woman treated with trastuzumab
title_full_unstemmed	Reversible cardiotoxicity in a 54-year-old woman treated with trastuzumab
title_sort	reversible cardiotoxicity in a 54-year-old woman treated with trastuzumab
publisher	Sociedad Médica de Santiago
publishDate	2012
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872012000600010
work_keys_str_mv	AT martinssandrojose reversiblecardiotoxicityina54yearoldwomantreatedwithtrastuzumab AT modestodossantosvitorino reversiblecardiotoxicityina54yearoldwomantreatedwithtrastuzumab AT thommentelesludmila reversiblecardiotoxicityina54yearoldwomantreatedwithtrastuzumab AT alvesleiteviviane reversiblecardiotoxicityina54yearoldwomantreatedwithtrastuzumab
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Reversible cardiotoxicity in a 54-year-old woman treated with trastuzumab

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