Consideraciones farmacocinéticas en el paciente crítico

Background: Critically ill patients in Intensive Care Units (ICUs) are exposed to multiple procedures and usually require complex treatment regimens. Many of them suffer from comorbidities and different complications such as organ failure, drug-drug interactions, and unusual therapeutic intervention...

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Autores principales:	Escobar,Leslie, Gai,María Nella, Regueira,Tomás, Andresen,Max
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2012
Materias:	Drug toxicity Intensive care units Pharmacokinetics
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872012000600014
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spelling	oai:scielo:S0034-988720120006000142014-03-10Consideraciones farmacocinéticas en el paciente críticoEscobar,LeslieGai,María NellaRegueira,TomásAndresen,Max Drug toxicity Intensive care units Pharmacokinetics Background: Critically ill patients in Intensive Care Units (ICUs) are exposed to multiple procedures and usually require complex treatment regimens. Many of them suffer from comorbidities and different complications such as organ failure, drug-drug interactions, and unusual therapeutic interventions that can produce significant pathophysiologic changes. For that reason, pharmacokinetics for several substances is different to what is described for healthy patients, complicating drug selection and drug dosage to achieve appropriate effects. Low doses may determine a reduction of drug effectiveness and overdoses leading to toxicity. The aim of this paper is to review the pharmacokinetic considerations that must be considered when treating acute ICU patients.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.140 n.6 20122012-06-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872012000600014es10.4067/S0034-98872012000600014
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Drug toxicity Intensive care units Pharmacokinetics
spellingShingle	Drug toxicity Intensive care units Pharmacokinetics Escobar,Leslie Gai,María Nella Regueira,Tomás Andresen,Max Consideraciones farmacocinéticas en el paciente crítico
description	Background: Critically ill patients in Intensive Care Units (ICUs) are exposed to multiple procedures and usually require complex treatment regimens. Many of them suffer from comorbidities and different complications such as organ failure, drug-drug interactions, and unusual therapeutic interventions that can produce significant pathophysiologic changes. For that reason, pharmacokinetics for several substances is different to what is described for healthy patients, complicating drug selection and drug dosage to achieve appropriate effects. Low doses may determine a reduction of drug effectiveness and overdoses leading to toxicity. The aim of this paper is to review the pharmacokinetic considerations that must be considered when treating acute ICU patients.
author	Escobar,Leslie Gai,María Nella Regueira,Tomás Andresen,Max
author_facet	Escobar,Leslie Gai,María Nella Regueira,Tomás Andresen,Max
author_sort	Escobar,Leslie
title	Consideraciones farmacocinéticas en el paciente crítico
title_short	Consideraciones farmacocinéticas en el paciente crítico
title_full	Consideraciones farmacocinéticas en el paciente crítico
title_fullStr	Consideraciones farmacocinéticas en el paciente crítico
title_full_unstemmed	Consideraciones farmacocinéticas en el paciente crítico
title_sort	consideraciones farmacocinéticas en el paciente crítico
publisher	Sociedad Médica de Santiago
publishDate	2012
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872012000600014
work_keys_str_mv	AT escobarleslie consideracionesfarmacocineticasenelpacientecritico AT gaimarianella consideracionesfarmacocineticasenelpacientecritico AT regueiratomas consideracionesfarmacocineticasenelpacientecritico AT andresenmax consideracionesfarmacocineticasenelpacientecritico
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Consideraciones farmacocinéticas en el paciente crítico

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