Marcadores de síndrome metabólico como predictores de elevación de alanino aminotransferasa en niños

Background: There is a high prevalence of non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) among pediatric patients. The identification of clinical predictors of these conditions would allow a timely treatment. Aim: To evaluate the relationship between serum alanine...

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Autores principales:	Arancibia,Gabriel, García,Hernán, Jaime,Francisca, Bancalari,Rodrigo, Harris,Paul R
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2012
Materias:	Alanine transaminase Child Fatty liver Metabolic syndrome X
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872012000700010
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spelling	oai:scielo:S0034-988720120007000102012-10-22Marcadores de síndrome metabólico como predictores de elevación de alanino aminotransferasa en niñosArancibia,GabrielGarcía,HernánJaime,FranciscaBancalari,RodrigoHarris,Paul R Alanine transaminase Child Fatty liver Metabolic syndrome X Background: There is a high prevalence of non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) among pediatric patients. The identification of clinical predictors of these conditions would allow a timely treatment. Aim: To evaluate the relationship between serum alanine aminotransferase levels and parameters of metabolic syndrome in asymptomatic school students without hepatic illness. Subjects and Methods: A randomized sample of 175 children aged between 9 and 14 years (54% females) was selected, from a database of 3010 students living in Santiago, Chile. Weight, height, abdominal circumference, systolic and diastolic blood pressure were measured. A fasting blood sample was obtained to measure glucose, total cholesterol, HDL, LDL-cholesterol, triglycerides, alanine aminotransferase (ALT) and insulin levels. Results: Forty percent of participants were obese, 17% had metabolic syndrome and 13.1% had abnormal ALT levels. Compared with children with normal ALT levels, the latter had significantly higher waist obesity, body mass index, systolic and diastolic blood pressure and triglycerides. However on multiva-riate analysis, only waist obesity was independently associated with abnormal ALT levels (adjusted odds ratio 3.93, 95% confidence intervals 1.44-10.78, p = 0.008). Conclusions: Only waist obesity was independently associated with abnormal ALT levels in this sample of children.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.140 n.7 20122012-07-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872012000700010es10.4067/S0034-98872012000700010
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Alanine transaminase Child Fatty liver Metabolic syndrome X
spellingShingle	Alanine transaminase Child Fatty liver Metabolic syndrome X Arancibia,Gabriel García,Hernán Jaime,Francisca Bancalari,Rodrigo Harris,Paul R Marcadores de síndrome metabólico como predictores de elevación de alanino aminotransferasa en niños
description	Background: There is a high prevalence of non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) among pediatric patients. The identification of clinical predictors of these conditions would allow a timely treatment. Aim: To evaluate the relationship between serum alanine aminotransferase levels and parameters of metabolic syndrome in asymptomatic school students without hepatic illness. Subjects and Methods: A randomized sample of 175 children aged between 9 and 14 years (54% females) was selected, from a database of 3010 students living in Santiago, Chile. Weight, height, abdominal circumference, systolic and diastolic blood pressure were measured. A fasting blood sample was obtained to measure glucose, total cholesterol, HDL, LDL-cholesterol, triglycerides, alanine aminotransferase (ALT) and insulin levels. Results: Forty percent of participants were obese, 17% had metabolic syndrome and 13.1% had abnormal ALT levels. Compared with children with normal ALT levels, the latter had significantly higher waist obesity, body mass index, systolic and diastolic blood pressure and triglycerides. However on multiva-riate analysis, only waist obesity was independently associated with abnormal ALT levels (adjusted odds ratio 3.93, 95% confidence intervals 1.44-10.78, p = 0.008). Conclusions: Only waist obesity was independently associated with abnormal ALT levels in this sample of children.
author	Arancibia,Gabriel García,Hernán Jaime,Francisca Bancalari,Rodrigo Harris,Paul R
author_facet	Arancibia,Gabriel García,Hernán Jaime,Francisca Bancalari,Rodrigo Harris,Paul R
author_sort	Arancibia,Gabriel
title	Marcadores de síndrome metabólico como predictores de elevación de alanino aminotransferasa en niños
title_short	Marcadores de síndrome metabólico como predictores de elevación de alanino aminotransferasa en niños
title_full	Marcadores de síndrome metabólico como predictores de elevación de alanino aminotransferasa en niños
title_fullStr	Marcadores de síndrome metabólico como predictores de elevación de alanino aminotransferasa en niños
title_full_unstemmed	Marcadores de síndrome metabólico como predictores de elevación de alanino aminotransferasa en niños
title_sort	marcadores de síndrome metabólico como predictores de elevación de alanino aminotransferasa en niños
publisher	Sociedad Médica de Santiago
publishDate	2012
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872012000700010
work_keys_str_mv	AT arancibiagabriel marcadoresdesindromemetabolicocomopredictoresdeelevaciondealaninoaminotransferasaenninos AT garciahernan marcadoresdesindromemetabolicocomopredictoresdeelevaciondealaninoaminotransferasaenninos AT jaimefrancisca marcadoresdesindromemetabolicocomopredictoresdeelevaciondealaninoaminotransferasaenninos AT bancalarirodrigo marcadoresdesindromemetabolicocomopredictoresdeelevaciondealaninoaminotransferasaenninos AT harrispaulr marcadoresdesindromemetabolicocomopredictoresdeelevaciondealaninoaminotransferasaenninos
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Marcadores de síndrome metabólico como predictores de elevación de alanino aminotransferasa en niños

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