Síndrome de ovario poliquístico y embarazo

Background: Polycystic ovary syndrome (PCOS) is a common endocrine metabolic dysfunction closely associated with insulin resistance and obesity, which predisposes to pregnancy complications and prenatal programming of the offspring. The aim of this review is to report our experience in PCOS patients...

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Autores principales:	Sir-Petermann,Teresa, Ladrón de Guevara,Amanda, Villarroel,Ana Claudia, Preisler,Jessica, Echiburú,Bárbara, Recabarren,Sergio
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2012
Materias:	Birth weight Diabetes gestational Polycystic ovary syndrome Pregnancy complications
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872012000700015
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spelling	oai:scielo:S0034-988720120007000152012-10-22Síndrome de ovario poliquístico y embarazoSir-Petermann,TeresaLadrón de Guevara,AmandaVillarroel,Ana ClaudiaPreisler,JessicaEchiburú,BárbaraRecabarren,Sergio Birth weight Diabetes gestational Polycystic ovary syndrome Pregnancy complications Background: Polycystic ovary syndrome (PCOS) is a common endocrine metabolic dysfunction closely associated with insulin resistance and obesity, which predisposes to pregnancy complications and prenatal programming of the offspring. The aim of this review is to report our experience in PCOS patients who became pregnant and were followed during the whole pregnancy. Firstly, we analyzed the effect of pregnancy on PCOS pathophysiology and secondly the role of PCOS in pregnancy outcomes. Regarding the firstpoint, during normal pregnancy a progressive insulin resistance, serum lipid changes and an increase in androgen levels is observed, which is exacerbated in the PCOS condition. This adverse intrauterine environment could have a prenatal programming effect with detrimental consequences for female or male fetuses. Regarding the second point, PCOS is associated with an increased risk for maternal complications such as gestational diabetes (GDM) and pregnancy-induced hypertension. Moreover, these adverse pregnancy outcomes are more frequently associated with an increase in low birth weight and high birth weight newborns. According to our clinical experience, PCOS patients who became pregnant and were not treated with metformin during the whole pregnancy, showed a higher prevalence of gestational diabetes and SGA newborns, which was improved with metformin treatment. In summary, pregnancy may constitute a period in which an abnormal condition is established or aggravated in the fetus of a PCOS mother. Moreover, PCOS enhanced adverse obstetric and neonatal outcomes.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.140 n.7 20122012-07-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872012000700015es10.4067/S0034-98872012000700015
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Birth weight Diabetes gestational Polycystic ovary syndrome Pregnancy complications
spellingShingle	Birth weight Diabetes gestational Polycystic ovary syndrome Pregnancy complications Sir-Petermann,Teresa Ladrón de Guevara,Amanda Villarroel,Ana Claudia Preisler,Jessica Echiburú,Bárbara Recabarren,Sergio Síndrome de ovario poliquístico y embarazo
description	Background: Polycystic ovary syndrome (PCOS) is a common endocrine metabolic dysfunction closely associated with insulin resistance and obesity, which predisposes to pregnancy complications and prenatal programming of the offspring. The aim of this review is to report our experience in PCOS patients who became pregnant and were followed during the whole pregnancy. Firstly, we analyzed the effect of pregnancy on PCOS pathophysiology and secondly the role of PCOS in pregnancy outcomes. Regarding the firstpoint, during normal pregnancy a progressive insulin resistance, serum lipid changes and an increase in androgen levels is observed, which is exacerbated in the PCOS condition. This adverse intrauterine environment could have a prenatal programming effect with detrimental consequences for female or male fetuses. Regarding the second point, PCOS is associated with an increased risk for maternal complications such as gestational diabetes (GDM) and pregnancy-induced hypertension. Moreover, these adverse pregnancy outcomes are more frequently associated with an increase in low birth weight and high birth weight newborns. According to our clinical experience, PCOS patients who became pregnant and were not treated with metformin during the whole pregnancy, showed a higher prevalence of gestational diabetes and SGA newborns, which was improved with metformin treatment. In summary, pregnancy may constitute a period in which an abnormal condition is established or aggravated in the fetus of a PCOS mother. Moreover, PCOS enhanced adverse obstetric and neonatal outcomes.
author	Sir-Petermann,Teresa Ladrón de Guevara,Amanda Villarroel,Ana Claudia Preisler,Jessica Echiburú,Bárbara Recabarren,Sergio
author_facet	Sir-Petermann,Teresa Ladrón de Guevara,Amanda Villarroel,Ana Claudia Preisler,Jessica Echiburú,Bárbara Recabarren,Sergio
author_sort	Sir-Petermann,Teresa
title	Síndrome de ovario poliquístico y embarazo
title_short	Síndrome de ovario poliquístico y embarazo
title_full	Síndrome de ovario poliquístico y embarazo
title_fullStr	Síndrome de ovario poliquístico y embarazo
title_full_unstemmed	Síndrome de ovario poliquístico y embarazo
title_sort	síndrome de ovario poliquístico y embarazo
publisher	Sociedad Médica de Santiago
publishDate	2012
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872012000700015
work_keys_str_mv	AT sirpetermannteresa sindromedeovariopoliquisticoyembarazo AT ladrondeguevaraamanda sindromedeovariopoliquisticoyembarazo AT villarroelanaclaudia sindromedeovariopoliquisticoyembarazo AT preislerjessica sindromedeovariopoliquisticoyembarazo AT echiburubarbara sindromedeovariopoliquisticoyembarazo AT recabarrensergio sindromedeovariopoliquisticoyembarazo
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Síndrome de ovario poliquístico y embarazo

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