Fenotipos clínicos en enfermedad pulmonar obstructiva crónica: ¿volver al futuro?

Background: Chronic obstructive pulmonary disease (COPD) is a complex and heterogeneous disease, that is defined by the degree of obstruction rendered by the forced expiratory volume in the first second (FEVj). This is a good parameter to define the severity of the disease but does not account for i...

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Autor principal: Silva O,Rafael
Lenguaje:Spanish / Castilian
Publicado: Sociedad Médica de Santiago 2012
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Acceso en línea:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872012000700016
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spelling oai:scielo:S0034-988720120007000162012-10-22Fenotipos clínicos en enfermedad pulmonar obstructiva crónica: ¿volver al futuro?Silva O,Rafael Bronchitis chronic Phenotype Pulmonary disease chronic obstructive Background: Chronic obstructive pulmonary disease (COPD) is a complex and heterogeneous disease, that is defined by the degree of obstruction rendered by the forced expiratory volume in the first second (FEVj). This is a good parameter to define the severity of the disease but does not account for its heterogeneity and does not provide a good comprehension of its different clinical behaviors and responses to treatment. Therefore, the classification of these patients in different clinical phenotypes has been attempted, trying to search for common clinical behaviors and responses to treatment. These phenoptypes must be validated in longitudinal studies. Some of the phenotypes detected are COPD with chronic respiratory failure and responsive to home oxygen therapy, COPD with upper lobe emphysema and responsive to volume reduction surgery, COPD with frequent exacerbation behavior, COPD resembling bronchitis and responsive to Roflumilast and possibly, COPD with systemic involvement. Historically, the phenotypes pink puffer, blue bloater, chronic bronchitis were defined. In the next years, we will know if the definitions of these phenotypes will aid in the management of patients with COPD.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.140 n.7 20122012-07-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872012000700016es10.4067/S0034-98872012000700016
institution Scielo Chile
collection Scielo Chile
language Spanish / Castilian
topic Bronchitis
chronic
Phenotype
Pulmonary disease
chronic obstructive
spellingShingle Bronchitis
chronic
Phenotype
Pulmonary disease
chronic obstructive
Silva O,Rafael
Fenotipos clínicos en enfermedad pulmonar obstructiva crónica: ¿volver al futuro?
description Background: Chronic obstructive pulmonary disease (COPD) is a complex and heterogeneous disease, that is defined by the degree of obstruction rendered by the forced expiratory volume in the first second (FEVj). This is a good parameter to define the severity of the disease but does not account for its heterogeneity and does not provide a good comprehension of its different clinical behaviors and responses to treatment. Therefore, the classification of these patients in different clinical phenotypes has been attempted, trying to search for common clinical behaviors and responses to treatment. These phenoptypes must be validated in longitudinal studies. Some of the phenotypes detected are COPD with chronic respiratory failure and responsive to home oxygen therapy, COPD with upper lobe emphysema and responsive to volume reduction surgery, COPD with frequent exacerbation behavior, COPD resembling bronchitis and responsive to Roflumilast and possibly, COPD with systemic involvement. Historically, the phenotypes pink puffer, blue bloater, chronic bronchitis were defined. In the next years, we will know if the definitions of these phenotypes will aid in the management of patients with COPD.
author Silva O,Rafael
author_facet Silva O,Rafael
author_sort Silva O,Rafael
title Fenotipos clínicos en enfermedad pulmonar obstructiva crónica: ¿volver al futuro?
title_short Fenotipos clínicos en enfermedad pulmonar obstructiva crónica: ¿volver al futuro?
title_full Fenotipos clínicos en enfermedad pulmonar obstructiva crónica: ¿volver al futuro?
title_fullStr Fenotipos clínicos en enfermedad pulmonar obstructiva crónica: ¿volver al futuro?
title_full_unstemmed Fenotipos clínicos en enfermedad pulmonar obstructiva crónica: ¿volver al futuro?
title_sort fenotipos clínicos en enfermedad pulmonar obstructiva crónica: ¿volver al futuro?
publisher Sociedad Médica de Santiago
publishDate 2012
url http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872012000700016
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