Relación colesterol total a HDL y colesterol no HDL: los mejores indicadores lipídicos de aumento de grosor de la íntima media carotidea

Relación colesterol total a HDL y colesterol no HDL: los mejores indicadores lipídicos de aumento de grosor de la íntima media carotidea

Background: LDL, HDL cholesterol and triglycerides, are the most commonly used lipid cardiovascular risk predictor indicators. However population based studies have shown that non-HDL cholesterol and total/HDL cholesterol ratio are better predictors, are easy to measure and do not require fasting. A...

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Autores principales: Acevedo,Mónica, Krämer,Verónica, Tagle,Rodrigo, Corbalán,Ramón, Arnaíz,Pilar, Berríos,Ximena, Navarrete,Carlos
Lenguaje:Spanish / Castilian
Publicado: Sociedad Médica de Santiago 2012
Materias:
Carotid intimae-media thickness
Cholesterol
Risk factors
Acceso en línea:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872012000800001
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spelling oai:scielo:S0034-988720120008000012012-12-18Relación colesterol total a HDL y colesterol no HDL: los mejores indicadores lipídicos de aumento de grosor de la íntima media carotideaAcevedo,MónicaKrämer,VerónicaTagle,RodrigoCorbalán,RamónArnaíz,PilarBerríos,XimenaNavarrete,Carlos Carotid intimae-media thickness Cholesterol Risk factors Background: LDL, HDL cholesterol and triglycerides, are the most commonly used lipid cardiovascular risk predictor indicators. However population based studies have shown that non-HDL cholesterol and total/HDL cholesterol ratio are better predictors, are easy to measure and do not require fasting. Aim: To determine which lipid indicators are better determinants of subclinical atherosclerosis, measured by intima media thickness (IMT) among subjects without demonstrated atherosclerosis. Material and Methods: Lipid profile, height, weight, blood pressure and bilateral IMT, measured by ultrasound with automatic border recognition software, were assessed in 770 men and 854 women aged 45 ± 11 years, in Santiago de Chile. Results: Mean total cholesterol was 202, HDL 50, LDL 121, triglycerides 157 and non-HDL cholesterol 152 mg/dl. Total/HDL cholesterol ratio was 4.3. MeanIMTwas 0.62 mm. All lipid markers were significantly correlated with IMT. This correlation was higher for non-HDL cholesterol (r = 0.24, p < 0.0001) and total/HDL cholesterol ratio(r = 0.23, p < 0.0001). In both men and women, total/HDL cholesterol ratio was the best predictor of having an IMT over the 75th percentile (odds ratio 1.21, 95% confidence intervals 1.09-1.35, p < 0.01). Conclusions: Total/HDL cholesterol ratio was the best determinant of subclinical atherosclerosis.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.140 n.8 20122012-08-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872012000800001es10.4067/S0034-98872012000800001
institution Scielo Chile
collection Scielo Chile
language Spanish / Castilian
topic Carotid intimae-media thickness
Cholesterol
Risk factors
spellingShingle Carotid intimae-media thickness
Cholesterol
Risk factors
Acevedo,Mónica
Krämer,Verónica
Tagle,Rodrigo
Corbalán,Ramón
Arnaíz,Pilar
Berríos,Ximena
Navarrete,Carlos
Relación colesterol total a HDL y colesterol no HDL: los mejores indicadores lipídicos de aumento de grosor de la íntima media carotidea
description Background: LDL, HDL cholesterol and triglycerides, are the most commonly used lipid cardiovascular risk predictor indicators. However population based studies have shown that non-HDL cholesterol and total/HDL cholesterol ratio are better predictors, are easy to measure and do not require fasting. Aim: To determine which lipid indicators are better determinants of subclinical atherosclerosis, measured by intima media thickness (IMT) among subjects without demonstrated atherosclerosis. Material and Methods: Lipid profile, height, weight, blood pressure and bilateral IMT, measured by ultrasound with automatic border recognition software, were assessed in 770 men and 854 women aged 45 ± 11 years, in Santiago de Chile. Results: Mean total cholesterol was 202, HDL 50, LDL 121, triglycerides 157 and non-HDL cholesterol 152 mg/dl. Total/HDL cholesterol ratio was 4.3. MeanIMTwas 0.62 mm. All lipid markers were significantly correlated with IMT. This correlation was higher for non-HDL cholesterol (r = 0.24, p < 0.0001) and total/HDL cholesterol ratio(r = 0.23, p < 0.0001). In both men and women, total/HDL cholesterol ratio was the best predictor of having an IMT over the 75th percentile (odds ratio 1.21, 95% confidence intervals 1.09-1.35, p < 0.01). Conclusions: Total/HDL cholesterol ratio was the best determinant of subclinical atherosclerosis.
author Acevedo,Mónica
Krämer,Verónica
Tagle,Rodrigo
Corbalán,Ramón
Arnaíz,Pilar
Berríos,Ximena
Navarrete,Carlos
author_facet Acevedo,Mónica
Krämer,Verónica
Tagle,Rodrigo
Corbalán,Ramón
Arnaíz,Pilar
Berríos,Ximena
Navarrete,Carlos
author_sort Acevedo,Mónica
title Relación colesterol total a HDL y colesterol no HDL: los mejores indicadores lipídicos de aumento de grosor de la íntima media carotidea
title_short Relación colesterol total a HDL y colesterol no HDL: los mejores indicadores lipídicos de aumento de grosor de la íntima media carotidea
title_full Relación colesterol total a HDL y colesterol no HDL: los mejores indicadores lipídicos de aumento de grosor de la íntima media carotidea
title_fullStr Relación colesterol total a HDL y colesterol no HDL: los mejores indicadores lipídicos de aumento de grosor de la íntima media carotidea
title_full_unstemmed Relación colesterol total a HDL y colesterol no HDL: los mejores indicadores lipídicos de aumento de grosor de la íntima media carotidea
title_sort relación colesterol total a hdl y colesterol no hdl: los mejores indicadores lipídicos de aumento de grosor de la íntima media carotidea
publisher Sociedad Médica de Santiago
publishDate 2012
url http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872012000800001
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