Modelo de regresión logística binaria para el diagnóstico morfológico de lesiones por virus del papiloma humano (VPH) en la boca

Background: Oral lesions caused by human papillomavirus (HPV), share morphological features which may complicate their diagnosis. Aim: To analyze the usefulness of Toki's morphological criteria for the diagnosis of HPV lesions in cervix, in the diagnosis of oral lesions. Materials and Methods:...

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Autores principales:	Bermeo E,Josué R, González L,Blanca S, Ramón G,Eva, Mendieta Z,Hugo
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2012
Materias:	Condylomata acuminate Warts
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872012000800009
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spelling	oai:scielo:S0034-988720120008000092012-12-18Modelo de regresión logística binaria para el diagnóstico morfológico de lesiones por virus del papiloma humano (VPH) en la bocaBermeo E,Josué RGonzález L,Blanca SRamón G,EvaMendieta Z,Hugo Condylomata acuminate Warts Background: Oral lesions caused by human papillomavirus (HPV), share morphological features which may complicate their diagnosis. Aim: To analyze the usefulness of Toki's morphological criteria for the diagnosis of HPV lesions in cervix, in the diagnosis of oral lesions. Materials and Methods: Retrospective study of 355 oral lesions by HPV. The pathologic evaluation was carried out three times by the same examiner with a Kappa coefficient of 0.780 (p = 0.01). Toki's criteria scored the presence of acanthosis as 1, dyskeratosis as 1, koilocytosis as 4, basilar hyperplasia as 1, bi or multinucleated cells as 2 and papillomatosis as 1. The information was analyzed using χ² and binary logistic regression. Results: Fifty eight percent of cases (207) corresponded to Verruca Vulgaris (VV), 23% (80) to Multifocal Epithelial Hyperplasia (MEH), and 19% (68) to Condyloma Acuminatum (CA). According to Toki's criteria, 76/80 MEH lesions, 195/207 of VV and 67/68 of CA, had a score equal or greater than six. A logistic regression showed that dyskeratosis suggests the presence of MEH. The presence of acanthosis and dyskeratosis in HPV oral lesions are not useful criteria for the diagnosis of VV. No significant associations with CA were found. Conclusions: The morphological criteria studied do not predict their possible viral etiology and do not allow a differential diagnosis of the lesions. Therefore, polymerase chain reaction studies are required to identify high-risk HPVs or sexually transmitted viral lesions.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.140 n.8 20122012-08-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872012000800009es10.4067/S0034-98872012000800009
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Condylomata acuminate Warts
spellingShingle	Condylomata acuminate Warts Bermeo E,Josué R González L,Blanca S Ramón G,Eva Mendieta Z,Hugo Modelo de regresión logística binaria para el diagnóstico morfológico de lesiones por virus del papiloma humano (VPH) en la boca
description	Background: Oral lesions caused by human papillomavirus (HPV), share morphological features which may complicate their diagnosis. Aim: To analyze the usefulness of Toki's morphological criteria for the diagnosis of HPV lesions in cervix, in the diagnosis of oral lesions. Materials and Methods: Retrospective study of 355 oral lesions by HPV. The pathologic evaluation was carried out three times by the same examiner with a Kappa coefficient of 0.780 (p = 0.01). Toki's criteria scored the presence of acanthosis as 1, dyskeratosis as 1, koilocytosis as 4, basilar hyperplasia as 1, bi or multinucleated cells as 2 and papillomatosis as 1. The information was analyzed using χ² and binary logistic regression. Results: Fifty eight percent of cases (207) corresponded to Verruca Vulgaris (VV), 23% (80) to Multifocal Epithelial Hyperplasia (MEH), and 19% (68) to Condyloma Acuminatum (CA). According to Toki's criteria, 76/80 MEH lesions, 195/207 of VV and 67/68 of CA, had a score equal or greater than six. A logistic regression showed that dyskeratosis suggests the presence of MEH. The presence of acanthosis and dyskeratosis in HPV oral lesions are not useful criteria for the diagnosis of VV. No significant associations with CA were found. Conclusions: The morphological criteria studied do not predict their possible viral etiology and do not allow a differential diagnosis of the lesions. Therefore, polymerase chain reaction studies are required to identify high-risk HPVs or sexually transmitted viral lesions.
author	Bermeo E,Josué R González L,Blanca S Ramón G,Eva Mendieta Z,Hugo
author_facet	Bermeo E,Josué R González L,Blanca S Ramón G,Eva Mendieta Z,Hugo
author_sort	Bermeo E,Josué R
title	Modelo de regresión logística binaria para el diagnóstico morfológico de lesiones por virus del papiloma humano (VPH) en la boca
title_short	Modelo de regresión logística binaria para el diagnóstico morfológico de lesiones por virus del papiloma humano (VPH) en la boca
title_full	Modelo de regresión logística binaria para el diagnóstico morfológico de lesiones por virus del papiloma humano (VPH) en la boca
title_fullStr	Modelo de regresión logística binaria para el diagnóstico morfológico de lesiones por virus del papiloma humano (VPH) en la boca
title_full_unstemmed	Modelo de regresión logística binaria para el diagnóstico morfológico de lesiones por virus del papiloma humano (VPH) en la boca
title_sort	modelo de regresión logística binaria para el diagnóstico morfológico de lesiones por virus del papiloma humano (vph) en la boca
publisher	Sociedad Médica de Santiago
publishDate	2012
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872012000800009
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Modelo de regresión logística binaria para el diagnóstico morfológico de lesiones por virus del papiloma humano (VPH) en la boca

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