Asociación entre polimorfismos del gen de adiponectina y estado nutricional en escolares de la comuna de Hualpén

Background: Several genetic polymorphisms of adiponectin have been associated to metabolic diseases as obesity and co-morbidities. Aim: To investigate if there are associations between +45TG, +276GT, -11,377CG y -11,391GA adiponectin SNPs (single nucleotide polymorphism) with obesity in a Chilean ch...

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Autores principales:	Orellana,Gloria, Sapunar,Jorge, Sáez,Katia, Aguayo,Claudio, Calvo,Carlos, Radojkovic,Claudia, Riffo,Benilde, Gleisner,Andrea, Asenjo,Sylvia, Ulloa,Natalia
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2012
Materias:	apM-1 protein Child Obesity Polymorphisms, Single Nucleotide
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872012001000002
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spelling	oai:scielo:S0034-988720120010000022013-03-18Asociación entre polimorfismos del gen de adiponectina y estado nutricional en escolares de la comuna de HualpénOrellana,GloriaSapunar,JorgeSáez,KatiaAguayo,ClaudioCalvo,CarlosRadojkovic,ClaudiaRiffo,BenildeGleisner,AndreaAsenjo,SylviaUlloa,Natalia apM-1 protein Child Obesity Polymorphisms, Single Nucleotide Background: Several genetic polymorphisms of adiponectin have been associated to metabolic diseases as obesity and co-morbidities. Aim: To investigate if there are associations between +45TG, +276GT, -11,377CG y -11,391GA adiponectin SNPs (single nucleotide polymorphism) with obesity in a Chilean children population. Material and Methods: A case-control study was performed in 241 obese and 126 normal weight children (7-11 years old) from the urban community of Hualpén, Biobío region. Children were classified as normal or obese, according to age and gender-specificpercentiles defined by Centerfor Disease Control and Prevention (CDC). The analysis of serum markers was carried out using commercial kits. Adiponectin polymorphisms were determined through a High Resolution Melting (HRM)-enabled real time PCR and by DNA fragment sequencing. Results: The observed allelic frequencies of the studied SNPs were over 11%. The 11,377CG polymorphism was associated with a high risk of obesity, calculated by the additive inheritance model (odds ratio = 1.389, 95% confidence interval: 1.001-1.929,p = 0.049). Conclusions: Obese school children of the Biobío Region, have an increased risk of carrying the susceptibility allele polymorphism 11377CG of adiponectin gene.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.140 n.10 20122012-10-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872012001000002es10.4067/S0034-98872012001000002
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	apM-1 protein Child Obesity Polymorphisms, Single Nucleotide
spellingShingle	apM-1 protein Child Obesity Polymorphisms, Single Nucleotide Orellana,Gloria Sapunar,Jorge Sáez,Katia Aguayo,Claudio Calvo,Carlos Radojkovic,Claudia Riffo,Benilde Gleisner,Andrea Asenjo,Sylvia Ulloa,Natalia Asociación entre polimorfismos del gen de adiponectina y estado nutricional en escolares de la comuna de Hualpén
description	Background: Several genetic polymorphisms of adiponectin have been associated to metabolic diseases as obesity and co-morbidities. Aim: To investigate if there are associations between +45TG, +276GT, -11,377CG y -11,391GA adiponectin SNPs (single nucleotide polymorphism) with obesity in a Chilean children population. Material and Methods: A case-control study was performed in 241 obese and 126 normal weight children (7-11 years old) from the urban community of Hualpén, Biobío region. Children were classified as normal or obese, according to age and gender-specificpercentiles defined by Centerfor Disease Control and Prevention (CDC). The analysis of serum markers was carried out using commercial kits. Adiponectin polymorphisms were determined through a High Resolution Melting (HRM)-enabled real time PCR and by DNA fragment sequencing. Results: The observed allelic frequencies of the studied SNPs were over 11%. The 11,377CG polymorphism was associated with a high risk of obesity, calculated by the additive inheritance model (odds ratio = 1.389, 95% confidence interval: 1.001-1.929,p = 0.049). Conclusions: Obese school children of the Biobío Region, have an increased risk of carrying the susceptibility allele polymorphism 11377CG of adiponectin gene.
author	Orellana,Gloria Sapunar,Jorge Sáez,Katia Aguayo,Claudio Calvo,Carlos Radojkovic,Claudia Riffo,Benilde Gleisner,Andrea Asenjo,Sylvia Ulloa,Natalia
author_facet	Orellana,Gloria Sapunar,Jorge Sáez,Katia Aguayo,Claudio Calvo,Carlos Radojkovic,Claudia Riffo,Benilde Gleisner,Andrea Asenjo,Sylvia Ulloa,Natalia
author_sort	Orellana,Gloria
title	Asociación entre polimorfismos del gen de adiponectina y estado nutricional en escolares de la comuna de Hualpén
title_short	Asociación entre polimorfismos del gen de adiponectina y estado nutricional en escolares de la comuna de Hualpén
title_full	Asociación entre polimorfismos del gen de adiponectina y estado nutricional en escolares de la comuna de Hualpén
title_fullStr	Asociación entre polimorfismos del gen de adiponectina y estado nutricional en escolares de la comuna de Hualpén
title_full_unstemmed	Asociación entre polimorfismos del gen de adiponectina y estado nutricional en escolares de la comuna de Hualpén
title_sort	asociación entre polimorfismos del gen de adiponectina y estado nutricional en escolares de la comuna de hualpén
publisher	Sociedad Médica de Santiago
publishDate	2012
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872012001000002
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Asociación entre polimorfismos del gen de adiponectina y estado nutricional en escolares de la comuna de Hualpén

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