Resultados del tratamiento de la hepatitis crónica por virus C en un hospital público, en Chile

Background: Chronic hepatitis C is an important health problem in Chile. In 2005, the Ministry of Health started a pilot treatment program with peg interferon and ribavirin, to be developed in public hospitals all over the country. Aim: To report the results ofhepatitis C treatment obtained at our i...

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Autores principales:	Aravena,Edmundo, Pinto,Andrea, Roblero,Juan Pablo, González Z,Marcela, Iturriaga,Hernán
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2012
Materias:	Hepatitis C, chronic Peginterferon alfa-2a Peginterferon alfa-2b Ribavirin
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872012001200002
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spelling	oai:scielo:S0034-988720120012000022013-05-02Resultados del tratamiento de la hepatitis crónica por virus C en un hospital público, en ChileAravena,EdmundoPinto,AndreaRoblero,Juan PabloGonzález Z,MarcelaIturriaga,Hernán Hepatitis C, chronic Peginterferon alfa-2a Peginterferon alfa-2b Ribavirin Background: Chronic hepatitis C is an important health problem in Chile. In 2005, the Ministry of Health started a pilot treatment program with peg interferon and ribavirin, to be developed in public hospitals all over the country. Aim: To report the results ofhepatitis C treatment obtained at our institution. Patients and Methods: Between 2005 and 2009, 63 patients were referred for treatment. In all, the viral load and genotype were determined. Peg interferon alpha-2a or alpha-2b plus ribavirin were used for therapy for up to 48 weeks in genotypes (G) 1 or 4 or 24 weeks in genotypes 2 or 3. If at the end oftreatment, viral load measured by polymerase chain reaction (PCR) was negative, it was repeated 6 months later. A negative viral load at that time was considered a sustained viral response (SVR). Results: Among the 51 patients who started treatment, 42 (80.4%) were G1,1 was G2,1 was G4 and 7 were G3. A SVR was reached in 51.1% ofG 1 and 4 and in 87.5% in G 3 and 2. In a univariate analysis, the variables significantly associated with a positive viral response were the degree offibrosis and body mass index. Conclusions: These results are similar to those obtained in other international series, demonstrating that Hispanic ethnicity does not influence the response to treatment. Our good results could be explained by the excellent compliance of the patients to the treatment. A higher degree offibrosis and a higher BMI were associated with a poor response.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.140 n.12 20122012-12-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872012001200002es10.4067/S0034-98872012001200002
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Hepatitis C, chronic Peginterferon alfa-2a Peginterferon alfa-2b Ribavirin
spellingShingle	Hepatitis C, chronic Peginterferon alfa-2a Peginterferon alfa-2b Ribavirin Aravena,Edmundo Pinto,Andrea Roblero,Juan Pablo González Z,Marcela Iturriaga,Hernán Resultados del tratamiento de la hepatitis crónica por virus C en un hospital público, en Chile
description	Background: Chronic hepatitis C is an important health problem in Chile. In 2005, the Ministry of Health started a pilot treatment program with peg interferon and ribavirin, to be developed in public hospitals all over the country. Aim: To report the results ofhepatitis C treatment obtained at our institution. Patients and Methods: Between 2005 and 2009, 63 patients were referred for treatment. In all, the viral load and genotype were determined. Peg interferon alpha-2a or alpha-2b plus ribavirin were used for therapy for up to 48 weeks in genotypes (G) 1 or 4 or 24 weeks in genotypes 2 or 3. If at the end oftreatment, viral load measured by polymerase chain reaction (PCR) was negative, it was repeated 6 months later. A negative viral load at that time was considered a sustained viral response (SVR). Results: Among the 51 patients who started treatment, 42 (80.4%) were G1,1 was G2,1 was G4 and 7 were G3. A SVR was reached in 51.1% ofG 1 and 4 and in 87.5% in G 3 and 2. In a univariate analysis, the variables significantly associated with a positive viral response were the degree offibrosis and body mass index. Conclusions: These results are similar to those obtained in other international series, demonstrating that Hispanic ethnicity does not influence the response to treatment. Our good results could be explained by the excellent compliance of the patients to the treatment. A higher degree offibrosis and a higher BMI were associated with a poor response.
author	Aravena,Edmundo Pinto,Andrea Roblero,Juan Pablo González Z,Marcela Iturriaga,Hernán
author_facet	Aravena,Edmundo Pinto,Andrea Roblero,Juan Pablo González Z,Marcela Iturriaga,Hernán
author_sort	Aravena,Edmundo
title	Resultados del tratamiento de la hepatitis crónica por virus C en un hospital público, en Chile
title_short	Resultados del tratamiento de la hepatitis crónica por virus C en un hospital público, en Chile
title_full	Resultados del tratamiento de la hepatitis crónica por virus C en un hospital público, en Chile
title_fullStr	Resultados del tratamiento de la hepatitis crónica por virus C en un hospital público, en Chile
title_full_unstemmed	Resultados del tratamiento de la hepatitis crónica por virus C en un hospital público, en Chile
title_sort	resultados del tratamiento de la hepatitis crónica por virus c en un hospital público, en chile
publisher	Sociedad Médica de Santiago
publishDate	2012
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872012001200002
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Resultados del tratamiento de la hepatitis crónica por virus C en un hospital público, en Chile

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