Bases fisiopatológicas para una clasificación de la neuropatía diabética

Nowadays, Diabetic Neuropathy (DN) is considered the most common cause of peripheral neuropathy in clinical practice. It can affect sensitive, motor or autonomic nerve fibers, with symmetric, asymmetric, acute or chronic presentations. Due to this variability, with multiple physiopathologic mechanis...

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Autores principales:	Olmos,Pablo R, Niklitschek,Sergio, Olmos,Roberto I, Faúndez,Jorge I, Quezada,Thomas A, Bozinovic,Milan A, Niklitschek,Ian A, Acosta,Jorge, Valencia,Claudio N, Bravo,Felipe A
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2012
Materias:	Diabetes complications Diabetic neuropathies Physiopathology
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872012001200012
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spelling	oai:scielo:S0034-988720120012000122013-05-02Bases fisiopatológicas para una clasificación de la neuropatía diabéticaOlmos,Pablo RNiklitschek,SergioOlmos,Roberto IFaúndez,Jorge IQuezada,Thomas ABozinovic,Milan ANiklitschek,Ian AAcosta,JorgeValencia,Claudio NBravo,Felipe A Diabetes complications Diabetic neuropathies Physiopathology Nowadays, Diabetic Neuropathy (DN) is considered the most common cause of peripheral neuropathy in clinical practice. It can affect sensitive, motor or autonomic nerve fibers, with symmetric, asymmetric, acute or chronic presentations. Due to this variability, with multiple physiopathologic mechanisms involved, a complex clinical classification has been used until recently. The aim of this review is to present a new classification of diabetic neuropathy, based on its physiopathology. It is divided in metabolic microvascular and hypoxic, autoimmune and inflammatory, compressive, secondary to complications ofdiabetes and related to treatment. It must be understood that DN is notjust a functional disease, but a complication of diabetes with molecular and pathological substrates caused by hyperglycemia. Therefore, normalization of blood glucose is a fundamental step towards the successful prevention and treatment of DN.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.140 n.12 20122012-12-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872012001200012es10.4067/S0034-98872012001200012
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Diabetes complications Diabetic neuropathies Physiopathology
spellingShingle	Diabetes complications Diabetic neuropathies Physiopathology Olmos,Pablo R Niklitschek,Sergio Olmos,Roberto I Faúndez,Jorge I Quezada,Thomas A Bozinovic,Milan A Niklitschek,Ian A Acosta,Jorge Valencia,Claudio N Bravo,Felipe A Bases fisiopatológicas para una clasificación de la neuropatía diabética
description	Nowadays, Diabetic Neuropathy (DN) is considered the most common cause of peripheral neuropathy in clinical practice. It can affect sensitive, motor or autonomic nerve fibers, with symmetric, asymmetric, acute or chronic presentations. Due to this variability, with multiple physiopathologic mechanisms involved, a complex clinical classification has been used until recently. The aim of this review is to present a new classification of diabetic neuropathy, based on its physiopathology. It is divided in metabolic microvascular and hypoxic, autoimmune and inflammatory, compressive, secondary to complications ofdiabetes and related to treatment. It must be understood that DN is notjust a functional disease, but a complication of diabetes with molecular and pathological substrates caused by hyperglycemia. Therefore, normalization of blood glucose is a fundamental step towards the successful prevention and treatment of DN.
author	Olmos,Pablo R Niklitschek,Sergio Olmos,Roberto I Faúndez,Jorge I Quezada,Thomas A Bozinovic,Milan A Niklitschek,Ian A Acosta,Jorge Valencia,Claudio N Bravo,Felipe A
author_facet	Olmos,Pablo R Niklitschek,Sergio Olmos,Roberto I Faúndez,Jorge I Quezada,Thomas A Bozinovic,Milan A Niklitschek,Ian A Acosta,Jorge Valencia,Claudio N Bravo,Felipe A
author_sort	Olmos,Pablo R
title	Bases fisiopatológicas para una clasificación de la neuropatía diabética
title_short	Bases fisiopatológicas para una clasificación de la neuropatía diabética
title_full	Bases fisiopatológicas para una clasificación de la neuropatía diabética
title_fullStr	Bases fisiopatológicas para una clasificación de la neuropatía diabética
title_full_unstemmed	Bases fisiopatológicas para una clasificación de la neuropatía diabética
title_sort	bases fisiopatológicas para una clasificación de la neuropatía diabética
publisher	Sociedad Médica de Santiago
publishDate	2012
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872012001200012
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Bases fisiopatológicas para una clasificación de la neuropatía diabética

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