El hábito de fumar se asocia a baja concentración plasmática de hormona antimülleriana en mujeres infértiles

Background: Smoking may hamperfemale fertility, probably modifying ovarian reserve. Antimüllerian hormone (AMH) is an accurate marker for ovarian reserve. Aim: To look for an association between smoking status and plasma AMH concentration. Patients and Methods: A cohort of 141 infertile women in a u...

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Autores principales:	Fuentes,Ariel, Escalona,Javier, Céspedes,Pablo, Repetto,Victoria, Iñiguez,German
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2013
Materias:	Age factors Anti-Mullerian hormone Infertility Smoking
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872013000100003
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spelling	oai:scielo:S0034-988720130001000032013-05-23El hábito de fumar se asocia a baja concentración plasmática de hormona antimülleriana en mujeres infértilesFuentes,ArielEscalona,JavierCéspedes,PabloRepetto,VictoriaIñiguez,German Age factors Anti-Mullerian hormone Infertility Smoking Background: Smoking may hamperfemale fertility, probably modifying ovarian reserve. Antimüllerian hormone (AMH) is an accurate marker for ovarian reserve. Aim: To look for an association between smoking status and plasma AMH concentration. Patients and Methods: A cohort of 141 infertile women in a university setting in Santiago, Chile was studied. Demographic and smoking data, including the number of cigarettes smoked during the last week, were collected. A blood sample was obtained and kept frozen until determination of AMH by ELISA and follicle stimulating hormone (FSH) and estradiol at day three of the menstrual cycle, by radioimmunoanalysis. Results: Thirty two participants smoked (23%). There were no significant differences in age, parity, body mass index, causes of infertility and day three FSH and estradiol between smokers and nonsmokers. According to a regression analysis, there was a significant decrease in AMH concentration with age and active cigarette smoking. A drop in AMH of -0.189 ng/mL with a unitary change in age and a decrease of -2.29 ng/mL when everything else remains constant, except the smoking status, were established (p < 0.001 and r2 = 0.134). However, no dose response was observed when the number of cigarettes smoked during the last week were introduced in the model. Furthermore, no significant association ofplasma AMH with day three plasma FSH and estradiol concentrations was observed. Conclusions: Cigarette smoking is associated with decreased AMHplasma concentrations among infertile women. However there was no dose response relationship. The mechanisms underlying this association are unknown and further investigation is required.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.141 n.1 20132013-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872013000100003es10.4067/S0034-98872013000100003
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Age factors Anti-Mullerian hormone Infertility Smoking
spellingShingle	Age factors Anti-Mullerian hormone Infertility Smoking Fuentes,Ariel Escalona,Javier Céspedes,Pablo Repetto,Victoria Iñiguez,German El hábito de fumar se asocia a baja concentración plasmática de hormona antimülleriana en mujeres infértiles
description	Background: Smoking may hamperfemale fertility, probably modifying ovarian reserve. Antimüllerian hormone (AMH) is an accurate marker for ovarian reserve. Aim: To look for an association between smoking status and plasma AMH concentration. Patients and Methods: A cohort of 141 infertile women in a university setting in Santiago, Chile was studied. Demographic and smoking data, including the number of cigarettes smoked during the last week, were collected. A blood sample was obtained and kept frozen until determination of AMH by ELISA and follicle stimulating hormone (FSH) and estradiol at day three of the menstrual cycle, by radioimmunoanalysis. Results: Thirty two participants smoked (23%). There were no significant differences in age, parity, body mass index, causes of infertility and day three FSH and estradiol between smokers and nonsmokers. According to a regression analysis, there was a significant decrease in AMH concentration with age and active cigarette smoking. A drop in AMH of -0.189 ng/mL with a unitary change in age and a decrease of -2.29 ng/mL when everything else remains constant, except the smoking status, were established (p < 0.001 and r2 = 0.134). However, no dose response was observed when the number of cigarettes smoked during the last week were introduced in the model. Furthermore, no significant association ofplasma AMH with day three plasma FSH and estradiol concentrations was observed. Conclusions: Cigarette smoking is associated with decreased AMHplasma concentrations among infertile women. However there was no dose response relationship. The mechanisms underlying this association are unknown and further investigation is required.
author	Fuentes,Ariel Escalona,Javier Céspedes,Pablo Repetto,Victoria Iñiguez,German
author_facet	Fuentes,Ariel Escalona,Javier Céspedes,Pablo Repetto,Victoria Iñiguez,German
author_sort	Fuentes,Ariel
title	El hábito de fumar se asocia a baja concentración plasmática de hormona antimülleriana en mujeres infértiles
title_short	El hábito de fumar se asocia a baja concentración plasmática de hormona antimülleriana en mujeres infértiles
title_full	El hábito de fumar se asocia a baja concentración plasmática de hormona antimülleriana en mujeres infértiles
title_fullStr	El hábito de fumar se asocia a baja concentración plasmática de hormona antimülleriana en mujeres infértiles
title_full_unstemmed	El hábito de fumar se asocia a baja concentración plasmática de hormona antimülleriana en mujeres infértiles
title_sort	el hábito de fumar se asocia a baja concentración plasmática de hormona antimülleriana en mujeres infértiles
publisher	Sociedad Médica de Santiago
publishDate	2013
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872013000100003
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El hábito de fumar se asocia a baja concentración plasmática de hormona antimülleriana en mujeres infértiles

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