Valor pronóstico del PET/CT en cáncer pulmonar: Estudio de sobrevida y caracterización metabólica tumoral

Background: PET/CT (Positron emission tomography/computed tomography) is a hybrid image modality widely used in oncology, for staging, therapy evaluation or follow up. Aim: To evaluate the prognostic value ofPET/CT in lung cancer. Material and Methods: Retrospective review of PET/CT records, selecti...

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Autores principales: Ladrón de Guevara,David, Fuentes,Aníbal, Fariña,Cyro, Corral,Camilo, Pefaur,Raúl
Lenguaje:Spanish / Castilian
Publicado: Sociedad Médica de Santiago 2013
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Acceso en línea:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872013000100006
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spelling oai:scielo:S0034-988720130001000062013-05-23Valor pronóstico del PET/CT en cáncer pulmonar: Estudio de sobrevida y caracterización metabólica tumoralLadrón de Guevara,DavidFuentes,AníbalFariña,CyroCorral,CamiloPefaur,Raúl Lung neoplasms Medical oncology Positron-emission tomography and computed tomography Prognosis Background: PET/CT (Positron emission tomography/computed tomography) is a hybrid image modality widely used in oncology, for staging, therapy evaluation or follow up. Aim: To evaluate the prognostic value ofPET/CT in lung cancer. Material and Methods: Retrospective review of PET/CT records, selecting 51 patients with a lung malignancy, mass or nodule referred for PET/CT between December 2008 and December 2010. All had pathological confirmation of malignancy and had not been treated previously. Age, gender, body mass index, radiological features of lung tumor and metastases, and lung tumor 18F-fluoro-2-deoxy-d-glucose uptake using the SUV (Standardized uptake value) index were recorded. Survival was analyzed usingKaplan-Meier curves and a Cox proportional regression analysis. Results: Pathology confirmed the presence of lung cancer in 47 patients aged 30 to 88 years. Four patients (7.8%) had other type of tumors such as carcinoid or lymphoma. Fifty percent of lung cancer patients died during a mean observation lapse of 18 months (range: 2-34 months). Patients with metastases, local lymph node involvement, a lung tumor size > 3 cm and high tumor uptake (SUVmax > 6) had significantly lower survival. Occurrence of metastases was the only independent prognostic factor in the Cox regression. A lung lesion with a SUVmax ≥ 12 was always associated to hilar/mediastinal lymph node involvement. Conclusions: PET/CT imaging gives important prognostic information in lung cancer patients.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.141 n.1 20132013-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872013000100006es10.4067/S0034-98872013000100006
institution Scielo Chile
collection Scielo Chile
language Spanish / Castilian
topic Lung neoplasms
Medical oncology
Positron-emission tomography and computed tomography
Prognosis
spellingShingle Lung neoplasms
Medical oncology
Positron-emission tomography and computed tomography
Prognosis
Ladrón de Guevara,David
Fuentes,Aníbal
Fariña,Cyro
Corral,Camilo
Pefaur,Raúl
Valor pronóstico del PET/CT en cáncer pulmonar: Estudio de sobrevida y caracterización metabólica tumoral
description Background: PET/CT (Positron emission tomography/computed tomography) is a hybrid image modality widely used in oncology, for staging, therapy evaluation or follow up. Aim: To evaluate the prognostic value ofPET/CT in lung cancer. Material and Methods: Retrospective review of PET/CT records, selecting 51 patients with a lung malignancy, mass or nodule referred for PET/CT between December 2008 and December 2010. All had pathological confirmation of malignancy and had not been treated previously. Age, gender, body mass index, radiological features of lung tumor and metastases, and lung tumor 18F-fluoro-2-deoxy-d-glucose uptake using the SUV (Standardized uptake value) index were recorded. Survival was analyzed usingKaplan-Meier curves and a Cox proportional regression analysis. Results: Pathology confirmed the presence of lung cancer in 47 patients aged 30 to 88 years. Four patients (7.8%) had other type of tumors such as carcinoid or lymphoma. Fifty percent of lung cancer patients died during a mean observation lapse of 18 months (range: 2-34 months). Patients with metastases, local lymph node involvement, a lung tumor size > 3 cm and high tumor uptake (SUVmax > 6) had significantly lower survival. Occurrence of metastases was the only independent prognostic factor in the Cox regression. A lung lesion with a SUVmax ≥ 12 was always associated to hilar/mediastinal lymph node involvement. Conclusions: PET/CT imaging gives important prognostic information in lung cancer patients.
author Ladrón de Guevara,David
Fuentes,Aníbal
Fariña,Cyro
Corral,Camilo
Pefaur,Raúl
author_facet Ladrón de Guevara,David
Fuentes,Aníbal
Fariña,Cyro
Corral,Camilo
Pefaur,Raúl
author_sort Ladrón de Guevara,David
title Valor pronóstico del PET/CT en cáncer pulmonar: Estudio de sobrevida y caracterización metabólica tumoral
title_short Valor pronóstico del PET/CT en cáncer pulmonar: Estudio de sobrevida y caracterización metabólica tumoral
title_full Valor pronóstico del PET/CT en cáncer pulmonar: Estudio de sobrevida y caracterización metabólica tumoral
title_fullStr Valor pronóstico del PET/CT en cáncer pulmonar: Estudio de sobrevida y caracterización metabólica tumoral
title_full_unstemmed Valor pronóstico del PET/CT en cáncer pulmonar: Estudio de sobrevida y caracterización metabólica tumoral
title_sort valor pronóstico del pet/ct en cáncer pulmonar: estudio de sobrevida y caracterización metabólica tumoral
publisher Sociedad Médica de Santiago
publishDate 2013
url http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872013000100006
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