Identificación de factor de crecimiento vascular endotelial en células glandulares de tejido prostético maligno y benigno: Relación con la recidiva tumoral al año de la prostatectomía

Background: Prostate cancer (PC) is the second cause of death by cancer in men in Chile. Its behavior is so variable that it is necessary to search reliable prognostic markers. Vascular Endothelial Growth Factor (VEGF) is one of the most powerful pro-angiogenic factors. There is no agreement on its...

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Autores principales: Acuña,Pedro, Ellwanger,Andrés, Ramírez,Angela, Cardemil,Felipe, Vega,Jorge, Casalino,Renato, Madrid,Eva
Lenguaje:Spanish / Castilian
Publicado: Sociedad Médica de Santiago 2013
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Acceso en línea:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872013000200002
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spelling oai:scielo:S0034-988720130002000022013-05-24Identificación de factor de crecimiento vascular endotelial en células glandulares de tejido prostético maligno y benigno: Relación con la recidiva tumoral al año de la prostatectomíaAcuña,PedroEllwanger,AndrésRamírez,AngelaCardemil,FelipeVega,JorgeCasalino,RenatoMadrid,Eva Prostatic hyperplasia Prostatic neoplasms Prostate-specific antigen Vascular endothelial growth factors Background: Prostate cancer (PC) is the second cause of death by cancer in men in Chile. Its behavior is so variable that it is necessary to search reliable prognostic markers. Vascular Endothelial Growth Factor (VEGF) is one of the most powerful pro-angiogenic factors. There is no agreement on its validity as a diagnostic or prognostic factor. Aim: To search for VEFG in prostatic tissue. Material and Methods: This study was performed in prostatectomy tissue coming from 41 patients with PC and 39 patients with benign prostatic hyperplasia (BPH). Specimens were studied using immunohistochemical staining for VEGF. The percentage of stained glandular cells per patient was calculated and associated with pathological diagnosis in cancer patients. Results: PC biopsies had a mean of 82% of VEGF (+) stained cells, while BPH had only 1.6% (p < 0.01). No relationship was found between the percentage of staining and recurrence at one year of follow-up in the case of PC. Conclusions: These results would rule out VEGF as a prognostic factor in this series of patients.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.141 n.2 20132013-02-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872013000200002es10.4067/S0034-98872013000200002
institution Scielo Chile
collection Scielo Chile
language Spanish / Castilian
topic Prostatic hyperplasia
Prostatic neoplasms
Prostate-specific antigen
Vascular endothelial growth factors
spellingShingle Prostatic hyperplasia
Prostatic neoplasms
Prostate-specific antigen
Vascular endothelial growth factors
Acuña,Pedro
Ellwanger,Andrés
Ramírez,Angela
Cardemil,Felipe
Vega,Jorge
Casalino,Renato
Madrid,Eva
Identificación de factor de crecimiento vascular endotelial en células glandulares de tejido prostético maligno y benigno: Relación con la recidiva tumoral al año de la prostatectomía
description Background: Prostate cancer (PC) is the second cause of death by cancer in men in Chile. Its behavior is so variable that it is necessary to search reliable prognostic markers. Vascular Endothelial Growth Factor (VEGF) is one of the most powerful pro-angiogenic factors. There is no agreement on its validity as a diagnostic or prognostic factor. Aim: To search for VEFG in prostatic tissue. Material and Methods: This study was performed in prostatectomy tissue coming from 41 patients with PC and 39 patients with benign prostatic hyperplasia (BPH). Specimens were studied using immunohistochemical staining for VEGF. The percentage of stained glandular cells per patient was calculated and associated with pathological diagnosis in cancer patients. Results: PC biopsies had a mean of 82% of VEGF (+) stained cells, while BPH had only 1.6% (p < 0.01). No relationship was found between the percentage of staining and recurrence at one year of follow-up in the case of PC. Conclusions: These results would rule out VEGF as a prognostic factor in this series of patients.
author Acuña,Pedro
Ellwanger,Andrés
Ramírez,Angela
Cardemil,Felipe
Vega,Jorge
Casalino,Renato
Madrid,Eva
author_facet Acuña,Pedro
Ellwanger,Andrés
Ramírez,Angela
Cardemil,Felipe
Vega,Jorge
Casalino,Renato
Madrid,Eva
author_sort Acuña,Pedro
title Identificación de factor de crecimiento vascular endotelial en células glandulares de tejido prostético maligno y benigno: Relación con la recidiva tumoral al año de la prostatectomía
title_short Identificación de factor de crecimiento vascular endotelial en células glandulares de tejido prostético maligno y benigno: Relación con la recidiva tumoral al año de la prostatectomía
title_full Identificación de factor de crecimiento vascular endotelial en células glandulares de tejido prostético maligno y benigno: Relación con la recidiva tumoral al año de la prostatectomía
title_fullStr Identificación de factor de crecimiento vascular endotelial en células glandulares de tejido prostético maligno y benigno: Relación con la recidiva tumoral al año de la prostatectomía
title_full_unstemmed Identificación de factor de crecimiento vascular endotelial en células glandulares de tejido prostético maligno y benigno: Relación con la recidiva tumoral al año de la prostatectomía
title_sort identificación de factor de crecimiento vascular endotelial en células glandulares de tejido prostético maligno y benigno: relación con la recidiva tumoral al año de la prostatectomía
publisher Sociedad Médica de Santiago
publishDate 2013
url http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872013000200002
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