Terapia endocrina neoadyuvante en cáncer de mama, una alternativa de tratamiento e investigación

Neoadjuvant chemotherapy is an accepted strategyforpatients with locally advanced breast cáncer. This approach increases the possibilities ofconservative treatment and improves the resectability rates ofinitially unresectable tumors. In addition, preoperative systemic therapy allows the evaluation o...

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Autores principales:	Acevedo,Francisco, Herrera,María Elisa, Madrid,Jorge, Sánchez,César
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2013
Materias:	Breast neoplasms Chemotherapy adjuvant Receptors estrogen
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872013000300013
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spelling	oai:scielo:S0034-988720130003000132013-11-15Terapia endocrina neoadyuvante en cáncer de mama, una alternativa de tratamiento e investigaciónAcevedo,FranciscoHerrera,María ElisaMadrid,JorgeSánchez,César Breast neoplasms Chemotherapy adjuvant Receptors estrogen Neoadjuvant chemotherapy is an accepted strategyforpatients with locally advanced breast cáncer. This approach increases the possibilities ofconservative treatment and improves the resectability rates ofinitially unresectable tumors. In addition, preoperative systemic therapy allows the evaluation of prognostic and predictive factors, dynamically and in vivo. Since over 80% ofthese tumors express estrogen receptors (ER), endocrine therapy seems a logical treatment to employ in the neoadjuvant setting. The advent ofnew drugs that regúlate the ERfunction, along with the results of severa! clinical studies with the use of neoadjuvant endocrine therapy, support the feasibility and safety of utilizing this strategy before surgery. We herein analyze the available clinical evidence about the use of neoadjuvant therapy aiming to regúlate the activity ofthe ER. We also discuss the valué of predictive factors that could help the oncologist to select those patients most likely to benefit from this approach and the role of endocrine therapy as a research instrument.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.141 n.3 20132013-03-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872013000300013es10.4067/S0034-98872013000300013
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Breast neoplasms Chemotherapy adjuvant Receptors estrogen
spellingShingle	Breast neoplasms Chemotherapy adjuvant Receptors estrogen Acevedo,Francisco Herrera,María Elisa Madrid,Jorge Sánchez,César Terapia endocrina neoadyuvante en cáncer de mama, una alternativa de tratamiento e investigación
description	Neoadjuvant chemotherapy is an accepted strategyforpatients with locally advanced breast cáncer. This approach increases the possibilities ofconservative treatment and improves the resectability rates ofinitially unresectable tumors. In addition, preoperative systemic therapy allows the evaluation of prognostic and predictive factors, dynamically and in vivo. Since over 80% ofthese tumors express estrogen receptors (ER), endocrine therapy seems a logical treatment to employ in the neoadjuvant setting. The advent ofnew drugs that regúlate the ERfunction, along with the results of severa! clinical studies with the use of neoadjuvant endocrine therapy, support the feasibility and safety of utilizing this strategy before surgery. We herein analyze the available clinical evidence about the use of neoadjuvant therapy aiming to regúlate the activity ofthe ER. We also discuss the valué of predictive factors that could help the oncologist to select those patients most likely to benefit from this approach and the role of endocrine therapy as a research instrument.
author	Acevedo,Francisco Herrera,María Elisa Madrid,Jorge Sánchez,César
author_facet	Acevedo,Francisco Herrera,María Elisa Madrid,Jorge Sánchez,César
author_sort	Acevedo,Francisco
title	Terapia endocrina neoadyuvante en cáncer de mama, una alternativa de tratamiento e investigación
title_short	Terapia endocrina neoadyuvante en cáncer de mama, una alternativa de tratamiento e investigación
title_full	Terapia endocrina neoadyuvante en cáncer de mama, una alternativa de tratamiento e investigación
title_fullStr	Terapia endocrina neoadyuvante en cáncer de mama, una alternativa de tratamiento e investigación
title_full_unstemmed	Terapia endocrina neoadyuvante en cáncer de mama, una alternativa de tratamiento e investigación
title_sort	terapia endocrina neoadyuvante en cáncer de mama, una alternativa de tratamiento e investigación
publisher	Sociedad Médica de Santiago
publishDate	2013
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872013000300013
work_keys_str_mv	AT acevedofrancisco terapiaendocrinaneoadyuvanteencancerdemamaunaalternativadetratamientoeinvestigacion AT herreramariaelisa terapiaendocrinaneoadyuvanteencancerdemamaunaalternativadetratamientoeinvestigacion AT madridjorge terapiaendocrinaneoadyuvanteencancerdemamaunaalternativadetratamientoeinvestigacion AT sanchezcesar terapiaendocrinaneoadyuvanteencancerdemamaunaalternativadetratamientoeinvestigacion
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Terapia endocrina neoadyuvante en cáncer de mama, una alternativa de tratamiento e investigación

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