Red neural por defecto y enfermedad de Alzheimer

Brainfunctioning is mainly intrinsic, notprimarily reflexive. This is supported by the high energy requirements ofthe resting brain (20% ofall the energy consumed) which only marginally increases with changes in brain activity. Modern neuroimaging and neurophysiological techniques have led to the di...

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Autores principales:	Vergara E,Fernando, Behrens,María Isabel
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2013
Materias:	Alzheimer disease Dementia Nerve net
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872013000300014
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spelling	oai:scielo:S0034-988720130003000142013-11-15Red neural por defecto y enfermedad de AlzheimerVergara E,FernandoBehrens,María Isabel Alzheimer disease Dementia Nerve net Brainfunctioning is mainly intrinsic, notprimarily reflexive. This is supported by the high energy requirements ofthe resting brain (20% ofall the energy consumed) which only marginally increases with changes in brain activity. Modern neuroimaging and neurophysiological techniques have led to the discovery of the so called brain default mode network (DMN), a constellation of brain regions which support brain activity at rest and whose discharges decrease during task-induced activities. Another characteristic ofthe DMN are the elevated levéis of aerobic glycolysis (Warburg effect), that is, metabolism ofglucose to lactic acid in thepresence ofsufficient levéis ofoxygen. In Alzheimer's disease there is amyloid deposition and metabolic disruption at the DMN regions. Changes in connectivity among the different nodes ofthe DMN and its connections with the hippocampus have been reported. The characteristics ofthe DMN and its relation to Alzheimer's disease are discussed. This issue is ofinterest in the pathogenesis and possibly for its usefulness as a biomarker ofthe disease.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.141 n.3 20132013-03-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872013000300014es10.4067/S0034-98872013000300014
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Alzheimer disease Dementia Nerve net
spellingShingle	Alzheimer disease Dementia Nerve net Vergara E,Fernando Behrens,María Isabel Red neural por defecto y enfermedad de Alzheimer
description	Brainfunctioning is mainly intrinsic, notprimarily reflexive. This is supported by the high energy requirements ofthe resting brain (20% ofall the energy consumed) which only marginally increases with changes in brain activity. Modern neuroimaging and neurophysiological techniques have led to the discovery of the so called brain default mode network (DMN), a constellation of brain regions which support brain activity at rest and whose discharges decrease during task-induced activities. Another characteristic ofthe DMN are the elevated levéis of aerobic glycolysis (Warburg effect), that is, metabolism ofglucose to lactic acid in thepresence ofsufficient levéis ofoxygen. In Alzheimer's disease there is amyloid deposition and metabolic disruption at the DMN regions. Changes in connectivity among the different nodes ofthe DMN and its connections with the hippocampus have been reported. The characteristics ofthe DMN and its relation to Alzheimer's disease are discussed. This issue is ofinterest in the pathogenesis and possibly for its usefulness as a biomarker ofthe disease.
author	Vergara E,Fernando Behrens,María Isabel
author_facet	Vergara E,Fernando Behrens,María Isabel
author_sort	Vergara E,Fernando
title	Red neural por defecto y enfermedad de Alzheimer
title_short	Red neural por defecto y enfermedad de Alzheimer
title_full	Red neural por defecto y enfermedad de Alzheimer
title_fullStr	Red neural por defecto y enfermedad de Alzheimer
title_full_unstemmed	Red neural por defecto y enfermedad de Alzheimer
title_sort	red neural por defecto y enfermedad de alzheimer
publisher	Sociedad Médica de Santiago
publishDate	2013
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872013000300014
work_keys_str_mv	AT vergaraefernando redneuralpordefectoyenfermedaddealzheimer AT behrensmariaisabel redneuralpordefectoyenfermedaddealzheimer
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Red neural por defecto y enfermedad de Alzheimer

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