Enfermedad renal por depósito idiopático de cadenas livianas: Caso clínico

Idiopathic Light Chain disease (ILCD) is a systemic disease characterized by a deposit in different organs of light chain monoclonal immunoglobulins, produced by an abnormal clone ofB cells. It is usually found in the course ofa plasma cell dyscrasia and in other lymphoproliferative alterations; how...

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Autores principales:	Trimarchi,Hernán, Lombi,Fernando, Forrester,Mariano, Pomeranz,Vanesa, Rabinovich,Oscar, Stemmelin,Germán R, Ruiz,Pablo A, Iotti,Alejandro, Young,Pablo
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2013
Materias:	Immunoglobulin Light chains Proteinuria Plasmapheresis Renal dialysis
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872013000300018
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spelling	oai:scielo:S0034-988720130003000182013-11-15Enfermedad renal por depósito idiopático de cadenas livianas: Caso clínicoTrimarchi,HernánLombi,FernandoForrester,MarianoPomeranz,VanesaRabinovich,OscarStemmelin,Germán RRuiz,Pablo AIotti,AlejandroYoung,Pablo Immunoglobulin Light chains Proteinuria Plasmapheresis Renal dialysis Idiopathic Light Chain disease (ILCD) is a systemic disease characterized by a deposit in different organs of light chain monoclonal immunoglobulins, produced by an abnormal clone ofB cells. It is usually found in the course ofa plasma cell dyscrasia and in other lymphoproliferative alterations; however it may occur in absence of any hematologic disease and is denominated as idiopathic. We report a 51-year-old mole admitted to the hospital due to anasarca. Laboratory evaluation showed a serum creatinine of 1.4 mg/dl, a serum albumin of1.6 g/dl, a serum cholesterol of 687 mg/dl and a proteinuria of 5.3 g/day Light chains with a predominance of a monoclonal component were identified in urinary proteins by electrophoresis and kappa chains were identified by immunofixation. A renal biopsy showed a diffuse nodular glomerulopathy with a 35% tubular atrophy and interstitial sclerosis. Electrón microscopy confirmed light chain deposition. The bone marrow biopsy showed a myeloid hyperplasia. Thepatient was initially treated with methylprednisolone and plasmapheresis with a reduction in serum creatinine and disappearance of urinary kappa component. Albuminuriapersisted and a malnutrition-inflammatory complex syndrome was diagnosed. Hemodialysis with ultrafiltration was started along with cyclophosphamide. Thepatient receivedhemodialysisforsixmonths and continued with methylprednisolone.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.141 n.3 20132013-03-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872013000300018es10.4067/S0034-98872013000300018
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Immunoglobulin Light chains Proteinuria Plasmapheresis Renal dialysis
spellingShingle	Immunoglobulin Light chains Proteinuria Plasmapheresis Renal dialysis Trimarchi,Hernán Lombi,Fernando Forrester,Mariano Pomeranz,Vanesa Rabinovich,Oscar Stemmelin,Germán R Ruiz,Pablo A Iotti,Alejandro Young,Pablo Enfermedad renal por depósito idiopático de cadenas livianas: Caso clínico
description	Idiopathic Light Chain disease (ILCD) is a systemic disease characterized by a deposit in different organs of light chain monoclonal immunoglobulins, produced by an abnormal clone ofB cells. It is usually found in the course ofa plasma cell dyscrasia and in other lymphoproliferative alterations; however it may occur in absence of any hematologic disease and is denominated as idiopathic. We report a 51-year-old mole admitted to the hospital due to anasarca. Laboratory evaluation showed a serum creatinine of 1.4 mg/dl, a serum albumin of1.6 g/dl, a serum cholesterol of 687 mg/dl and a proteinuria of 5.3 g/day Light chains with a predominance of a monoclonal component were identified in urinary proteins by electrophoresis and kappa chains were identified by immunofixation. A renal biopsy showed a diffuse nodular glomerulopathy with a 35% tubular atrophy and interstitial sclerosis. Electrón microscopy confirmed light chain deposition. The bone marrow biopsy showed a myeloid hyperplasia. Thepatient was initially treated with methylprednisolone and plasmapheresis with a reduction in serum creatinine and disappearance of urinary kappa component. Albuminuriapersisted and a malnutrition-inflammatory complex syndrome was diagnosed. Hemodialysis with ultrafiltration was started along with cyclophosphamide. Thepatient receivedhemodialysisforsixmonths and continued with methylprednisolone.
author	Trimarchi,Hernán Lombi,Fernando Forrester,Mariano Pomeranz,Vanesa Rabinovich,Oscar Stemmelin,Germán R Ruiz,Pablo A Iotti,Alejandro Young,Pablo
author_facet	Trimarchi,Hernán Lombi,Fernando Forrester,Mariano Pomeranz,Vanesa Rabinovich,Oscar Stemmelin,Germán R Ruiz,Pablo A Iotti,Alejandro Young,Pablo
author_sort	Trimarchi,Hernán
title	Enfermedad renal por depósito idiopático de cadenas livianas: Caso clínico
title_short	Enfermedad renal por depósito idiopático de cadenas livianas: Caso clínico
title_full	Enfermedad renal por depósito idiopático de cadenas livianas: Caso clínico
title_fullStr	Enfermedad renal por depósito idiopático de cadenas livianas: Caso clínico
title_full_unstemmed	Enfermedad renal por depósito idiopático de cadenas livianas: Caso clínico
title_sort	enfermedad renal por depósito idiopático de cadenas livianas: caso clínico
publisher	Sociedad Médica de Santiago
publishDate	2013
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872013000300018
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Enfermedad renal por depósito idiopático de cadenas livianas: Caso clínico

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