Comparison of propofol-based sedation regimens administered during colonoscopy

Background: The ideal sedative agent for endoscopic procedures should allow a rapid modification ofthe sedation level and should not have any adverse effects. Aim: To evaluate and compare the efficacy, safety, cost and patient satisfaction of some propofol-based sedation regimens administered during...

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Autores principales:	Akarsu Ayazoğlu,Tulin, Polat,Erdal, Bolat,Cihan, Yasar,Necdet F, Duman,Ugur, Akbulut,Sabiye, Yol,Sinan
Lenguaje:	English
Publicado:	Sociedad Médica de Santiago 2013
Materias:	Colonoscopy Conscious sedation Dexmedetomidine Midazolam Propofol Sufentanil
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872013000400009
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spelling	oai:scielo:S0034-988720130004000092013-09-11Comparison of propofol-based sedation regimens administered during colonoscopyAkarsu Ayazoğlu,TulinPolat,ErdalBolat,CihanYasar,Necdet FDuman,UgurAkbulut,SabiyeYol,Sinan Colonoscopy Conscious sedation Dexmedetomidine Midazolam Propofol Sufentanil Background: The ideal sedative agent for endoscopic procedures should allow a rapid modification ofthe sedation level and should not have any adverse effects. Aim: To evaluate and compare the efficacy, safety, cost and patient satisfaction of some propofol-based sedation regimens administered during colonoscopy. Material and Methods: One hundred twenty one patients scheduled for elective outpatient colonoscopy with conscious sedation were randomized to four groups to evaluate the administration of dexmedetomidine, sufentanil, meperidine and midazolam in combination with propofol to maintain sedation during the procedure. Evaluated outcomes were efficacy, safety, cost and patient satisfaction of sedation procedures. Results: Patients receiving dexmedetomidine achieved a higher degree of sedation when compared with the other groups (p < 0.05). The lapse to recoverprotective reflexes and motor function, was significantly shorter in groups receiving dexmedetomidine or sufentanil than in groups receiving meperidine or midazolam (p < 0.05). Therewere no differences between groups in pre-sedation and post-sedation neurophysiologic performance, measured by the Trail MakingA and B tests. Conclusions: Sedation for endoscopy can be safely and effectively accomplished with low doses of propofol combined with dexmedetomidine, intranasal sufentanil, IV meperidine and IV meperidine with midazolam.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.141 n.4 20132013-04-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872013000400009en10.4067/S0034-98872013000400009
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Colonoscopy Conscious sedation Dexmedetomidine Midazolam Propofol Sufentanil
spellingShingle	Colonoscopy Conscious sedation Dexmedetomidine Midazolam Propofol Sufentanil Akarsu Ayazoğlu,Tulin Polat,Erdal Bolat,Cihan Yasar,Necdet F Duman,Ugur Akbulut,Sabiye Yol,Sinan Comparison of propofol-based sedation regimens administered during colonoscopy
description	Background: The ideal sedative agent for endoscopic procedures should allow a rapid modification ofthe sedation level and should not have any adverse effects. Aim: To evaluate and compare the efficacy, safety, cost and patient satisfaction of some propofol-based sedation regimens administered during colonoscopy. Material and Methods: One hundred twenty one patients scheduled for elective outpatient colonoscopy with conscious sedation were randomized to four groups to evaluate the administration of dexmedetomidine, sufentanil, meperidine and midazolam in combination with propofol to maintain sedation during the procedure. Evaluated outcomes were efficacy, safety, cost and patient satisfaction of sedation procedures. Results: Patients receiving dexmedetomidine achieved a higher degree of sedation when compared with the other groups (p < 0.05). The lapse to recoverprotective reflexes and motor function, was significantly shorter in groups receiving dexmedetomidine or sufentanil than in groups receiving meperidine or midazolam (p < 0.05). Therewere no differences between groups in pre-sedation and post-sedation neurophysiologic performance, measured by the Trail MakingA and B tests. Conclusions: Sedation for endoscopy can be safely and effectively accomplished with low doses of propofol combined with dexmedetomidine, intranasal sufentanil, IV meperidine and IV meperidine with midazolam.
author	Akarsu Ayazoğlu,Tulin Polat,Erdal Bolat,Cihan Yasar,Necdet F Duman,Ugur Akbulut,Sabiye Yol,Sinan
author_facet	Akarsu Ayazoğlu,Tulin Polat,Erdal Bolat,Cihan Yasar,Necdet F Duman,Ugur Akbulut,Sabiye Yol,Sinan
author_sort	Akarsu Ayazoğlu,Tulin
title	Comparison of propofol-based sedation regimens administered during colonoscopy
title_short	Comparison of propofol-based sedation regimens administered during colonoscopy
title_full	Comparison of propofol-based sedation regimens administered during colonoscopy
title_fullStr	Comparison of propofol-based sedation regimens administered during colonoscopy
title_full_unstemmed	Comparison of propofol-based sedation regimens administered during colonoscopy
title_sort	comparison of propofol-based sedation regimens administered during colonoscopy
publisher	Sociedad Médica de Santiago
publishDate	2013
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872013000400009
work_keys_str_mv	AT akarsuayazo287lutulin comparisonofpropofolbasedsedationregimensadministeredduringcolonoscopy AT polaterdal comparisonofpropofolbasedsedationregimensadministeredduringcolonoscopy AT bolatcihan comparisonofpropofolbasedsedationregimensadministeredduringcolonoscopy AT yasarnecdetf comparisonofpropofolbasedsedationregimensadministeredduringcolonoscopy AT dumanugur comparisonofpropofolbasedsedationregimensadministeredduringcolonoscopy AT akbulutsabiye comparisonofpropofolbasedsedationregimensadministeredduringcolonoscopy AT yolsinan comparisonofpropofolbasedsedationregimensadministeredduringcolonoscopy
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Comparison of propofol-based sedation regimens administered during colonoscopy

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