Un índice neutrófilo/linfocito elevado se asocia a peor pronóstico en cáncer de colon etapa II resecado

Background: The neutrophil/lymphocyte ratio is an effective marker of inflammation ana can have prognostic value in surgical patients. Aim: To evaluate the effect of an increased neutrophil/lymphocyte ratio (NLR) on perioperative complications ana overall ana disease-free survival in patients underg...

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Autores principales:	Urrejola,Gonzalo I, Bambs,Claudia E, Espinoza,Manuel A, Gellona,José, Zúñiga,Álvaro M, Molina,María Elena, Bellolio,Felipe, Miguieles,Rodrigo, Campbell,James M, Pinedo,George A
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2013
Materias:	Colonic neoplasms Lymphocytes Neutrophils
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872013000500008
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spelling	oai:scielo:S0034-988720130005000082013-09-26Un índice neutrófilo/linfocito elevado se asocia a peor pronóstico en cáncer de colon etapa II resecadoUrrejola,Gonzalo IBambs,Claudia EEspinoza,Manuel AGellona,JoséZúñiga,Álvaro MMolina,María ElenaBellolio,FelipeMiguieles,RodrigoCampbell,James MPinedo,George A Colonic neoplasms Lymphocytes Neutrophils Background: The neutrophil/lymphocyte ratio is an effective marker of inflammation ana can have prognostic value in surgical patients. Aim: To evaluate the effect of an increased neutrophil/lymphocyte ratio (NLR) on perioperative complications ana overall ana disease-free survival in patients undergoing elective resection for stage II colon cancer. Material and Methods: Data was obtained from clinical charts, preoperative blood results and hospital records of all patients undergoing an elective curative resection for colon cancer, between 2000 and 2007. Preoperative NLR was calculated. Follow-up was obtained from a prospectively maintained colorectal cancer database, clinical records and questionnaires. Uni and multivariable analysis were performed to identify associations, and survival analysis was performed using Kaplan-Meier curves. Results: One hundred twenty two patients with a mean age of69years (52% males), were evaluated. Median follow-up was 73 months, and overall survival for 1 and 5years was 95% and 68%, respectively. On a multivariable analysis after adjusting for age, sex, tumor depth invasion, use of adjuvant therapies and American Society of Anesthesiology preoperative risk score, an NLR > 5 was associated with an increased perioperative complication rate (odds ratio: 3,06, p = 0,033). Kaplan-Meier survival analysis showed a worse overall and disease-free survival for patients with NLR greater than five. Conclusions: A preoperative NLR of five or more is associated with greater perioperative morbidity and worse oncological outcomes in patients undergoing resection for elective stage II colon cancer.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.141 n.5 20132013-05-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872013000500008es10.4067/S0034-98872013000500008
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Colonic neoplasms Lymphocytes Neutrophils
spellingShingle	Colonic neoplasms Lymphocytes Neutrophils Urrejola,Gonzalo I Bambs,Claudia E Espinoza,Manuel A Gellona,José Zúñiga,Álvaro M Molina,María Elena Bellolio,Felipe Miguieles,Rodrigo Campbell,James M Pinedo,George A Un índice neutrófilo/linfocito elevado se asocia a peor pronóstico en cáncer de colon etapa II resecado
description	Background: The neutrophil/lymphocyte ratio is an effective marker of inflammation ana can have prognostic value in surgical patients. Aim: To evaluate the effect of an increased neutrophil/lymphocyte ratio (NLR) on perioperative complications ana overall ana disease-free survival in patients undergoing elective resection for stage II colon cancer. Material and Methods: Data was obtained from clinical charts, preoperative blood results and hospital records of all patients undergoing an elective curative resection for colon cancer, between 2000 and 2007. Preoperative NLR was calculated. Follow-up was obtained from a prospectively maintained colorectal cancer database, clinical records and questionnaires. Uni and multivariable analysis were performed to identify associations, and survival analysis was performed using Kaplan-Meier curves. Results: One hundred twenty two patients with a mean age of69years (52% males), were evaluated. Median follow-up was 73 months, and overall survival for 1 and 5years was 95% and 68%, respectively. On a multivariable analysis after adjusting for age, sex, tumor depth invasion, use of adjuvant therapies and American Society of Anesthesiology preoperative risk score, an NLR > 5 was associated with an increased perioperative complication rate (odds ratio: 3,06, p = 0,033). Kaplan-Meier survival analysis showed a worse overall and disease-free survival for patients with NLR greater than five. Conclusions: A preoperative NLR of five or more is associated with greater perioperative morbidity and worse oncological outcomes in patients undergoing resection for elective stage II colon cancer.
author	Urrejola,Gonzalo I Bambs,Claudia E Espinoza,Manuel A Gellona,José Zúñiga,Álvaro M Molina,María Elena Bellolio,Felipe Miguieles,Rodrigo Campbell,James M Pinedo,George A
author_facet	Urrejola,Gonzalo I Bambs,Claudia E Espinoza,Manuel A Gellona,José Zúñiga,Álvaro M Molina,María Elena Bellolio,Felipe Miguieles,Rodrigo Campbell,James M Pinedo,George A
author_sort	Urrejola,Gonzalo I
title	Un índice neutrófilo/linfocito elevado se asocia a peor pronóstico en cáncer de colon etapa II resecado
title_short	Un índice neutrófilo/linfocito elevado se asocia a peor pronóstico en cáncer de colon etapa II resecado
title_full	Un índice neutrófilo/linfocito elevado se asocia a peor pronóstico en cáncer de colon etapa II resecado
title_fullStr	Un índice neutrófilo/linfocito elevado se asocia a peor pronóstico en cáncer de colon etapa II resecado
title_full_unstemmed	Un índice neutrófilo/linfocito elevado se asocia a peor pronóstico en cáncer de colon etapa II resecado
title_sort	un índice neutrófilo/linfocito elevado se asocia a peor pronóstico en cáncer de colon etapa ii resecado
publisher	Sociedad Médica de Santiago
publishDate	2013
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872013000500008
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Un índice neutrófilo/linfocito elevado se asocia a peor pronóstico en cáncer de colon etapa II resecado

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