Potencial herramienta en la personalización del tratamiento oncológico: Casos clínicos
Our laboratory has implemented an in vitro assay to estimate the response to chemotherapy in ovarian cancer cells pertaining to individual patients. In two selected patients, we determined the correlation between an in vitro assay of cells from suspected ovarian cancer ascites, with the clinical che...
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| Lenguaje: | Spanish / Castilian |
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Sociedad Médica de Santiago
2013
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| Acceso en línea: | http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872013000500017 |
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oai:scielo:S0034-988720130005000172013-09-26Potencial herramienta en la personalización del tratamiento oncológico: Casos clínicosIbáñez C,CarolinaGarrido S,MarceloMedina,LidiaKato,SumieBravo,María LoretoGonzález,PamelaOliva,BarbaraPizarro,JavierBustamante,EvaBrañes,JorgeCuello,MauricioOwen,Gareth I Antineoplastic protocols Ascitic fluid ovarian neoplasms Our laboratory has implemented an in vitro assay to estimate the response to chemotherapy in ovarian cancer cells pertaining to individual patients. In two selected patients, we determined the correlation between an in vitro assay of cells from suspected ovarian cancer ascites, with the clinical chemotherapy response. Cancer cells isolated from peritoneal fluid with suspected ovarian cancer were tested for cytotoxicity with corresponding chemotherapy regimens. Circulating Cal25 levels and attending physician consultation determined clinical course and response to chemotherapy. The in vitro assay result correlated with Cal25 levels, progression free survival and attending physician evaluation. The assay predicted correctly the failure of two successive chemotherapy regimes in the first patient, while predicting a favorable clinical response in the second subject.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.141 n.5 20132013-05-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872013000500017es10.4067/S0034-98872013000500017 |
| institution |
Scielo Chile |
| collection |
Scielo Chile |
| language |
Spanish / Castilian |
| topic |
Antineoplastic protocols Ascitic fluid ovarian neoplasms |
| spellingShingle |
Antineoplastic protocols Ascitic fluid ovarian neoplasms Ibáñez C,Carolina Garrido S,Marcelo Medina,Lidia Kato,Sumie Bravo,María Loreto González,Pamela Oliva,Barbara Pizarro,Javier Bustamante,Eva Brañes,Jorge Cuello,Mauricio Owen,Gareth I Potencial herramienta en la personalización del tratamiento oncológico: Casos clínicos |
| description |
Our laboratory has implemented an in vitro assay to estimate the response to chemotherapy in ovarian cancer cells pertaining to individual patients. In two selected patients, we determined the correlation between an in vitro assay of cells from suspected ovarian cancer ascites, with the clinical chemotherapy response. Cancer cells isolated from peritoneal fluid with suspected ovarian cancer were tested for cytotoxicity with corresponding chemotherapy regimens. Circulating Cal25 levels and attending physician consultation determined clinical course and response to chemotherapy. The in vitro assay result correlated with Cal25 levels, progression free survival and attending physician evaluation. The assay predicted correctly the failure of two successive chemotherapy regimes in the first patient, while predicting a favorable clinical response in the second subject. |
| author |
Ibáñez C,Carolina Garrido S,Marcelo Medina,Lidia Kato,Sumie Bravo,María Loreto González,Pamela Oliva,Barbara Pizarro,Javier Bustamante,Eva Brañes,Jorge Cuello,Mauricio Owen,Gareth I |
| author_facet |
Ibáñez C,Carolina Garrido S,Marcelo Medina,Lidia Kato,Sumie Bravo,María Loreto González,Pamela Oliva,Barbara Pizarro,Javier Bustamante,Eva Brañes,Jorge Cuello,Mauricio Owen,Gareth I |
| author_sort |
Ibáñez C,Carolina |
| title |
Potencial herramienta en la personalización del tratamiento oncológico: Casos clínicos |
| title_short |
Potencial herramienta en la personalización del tratamiento oncológico: Casos clínicos |
| title_full |
Potencial herramienta en la personalización del tratamiento oncológico: Casos clínicos |
| title_fullStr |
Potencial herramienta en la personalización del tratamiento oncológico: Casos clínicos |
| title_full_unstemmed |
Potencial herramienta en la personalización del tratamiento oncológico: Casos clínicos |
| title_sort |
potencial herramienta en la personalización del tratamiento oncológico: casos clínicos |
| publisher |
Sociedad Médica de Santiago |
| publishDate |
2013 |
| url |
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872013000500017 |
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