Purinas y ácido úrico en pre-eclampsia: interacciones fisiopatológicas y proyecciones en investigación

Uric acid is the final metabolite of purine break down, such as ATP, ADP, AMP, adenosine, inosine and hypoxanthine. The metabolite has been used broadly as a renal failure marker, as well as a risk factor for maternal and neonatal morbidity during pre-eclamptic pregnancies. High purine levels are ob...

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Autores principales:	Escudero,Carlos, Bertoglia,Patricio, Muñoz,Felipe, Roberts,James M
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2013
Materias:	Pre-eclampsia Purines Uric acid
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872013000700009
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spelling	oai:scielo:S0034-988720130007000092013-12-17Purinas y ácido úrico en pre-eclampsia: interacciones fisiopatológicas y proyecciones en investigaciónEscudero,CarlosBertoglia,PatricioMuñoz,FelipeRoberts,James M Pre-eclampsia Purines Uric acid Uric acid is the final metabolite of purine break down, such as ATP, ADP, AMP, adenosine, inosine and hypoxanthine. The metabolite has been used broadly as a renal failure marker, as well as a risk factor for maternal and neonatal morbidity during pre-eclamptic pregnancies. High purine levels are observed in pre-eclamptic pregnancies, but the sources of these purines are unknown. However, there is evidence that pre-eclampsia (mainly severe pre-eclampsia) is associated with an increased release of cellular fragments (or microparticles) from the placenta to the maternal circulation. These in fact could be the substrate for purine metabolism. Considering this background, we propose that purines and uric acid are part of the same physiopathological phenomenon in pre-eclampsia (i.e., placental dysfunction) and could become biomarkers for placental dysfunction and postnatal adverse events.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.141 n.7 20132013-07-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872013000700009es10.4067/S0034-98872013000700009
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Pre-eclampsia Purines Uric acid
spellingShingle	Pre-eclampsia Purines Uric acid Escudero,Carlos Bertoglia,Patricio Muñoz,Felipe Roberts,James M Purinas y ácido úrico en pre-eclampsia: interacciones fisiopatológicas y proyecciones en investigación
description	Uric acid is the final metabolite of purine break down, such as ATP, ADP, AMP, adenosine, inosine and hypoxanthine. The metabolite has been used broadly as a renal failure marker, as well as a risk factor for maternal and neonatal morbidity during pre-eclamptic pregnancies. High purine levels are observed in pre-eclamptic pregnancies, but the sources of these purines are unknown. However, there is evidence that pre-eclampsia (mainly severe pre-eclampsia) is associated with an increased release of cellular fragments (or microparticles) from the placenta to the maternal circulation. These in fact could be the substrate for purine metabolism. Considering this background, we propose that purines and uric acid are part of the same physiopathological phenomenon in pre-eclampsia (i.e., placental dysfunction) and could become biomarkers for placental dysfunction and postnatal adverse events.
author	Escudero,Carlos Bertoglia,Patricio Muñoz,Felipe Roberts,James M
author_facet	Escudero,Carlos Bertoglia,Patricio Muñoz,Felipe Roberts,James M
author_sort	Escudero,Carlos
title	Purinas y ácido úrico en pre-eclampsia: interacciones fisiopatológicas y proyecciones en investigación
title_short	Purinas y ácido úrico en pre-eclampsia: interacciones fisiopatológicas y proyecciones en investigación
title_full	Purinas y ácido úrico en pre-eclampsia: interacciones fisiopatológicas y proyecciones en investigación
title_fullStr	Purinas y ácido úrico en pre-eclampsia: interacciones fisiopatológicas y proyecciones en investigación
title_full_unstemmed	Purinas y ácido úrico en pre-eclampsia: interacciones fisiopatológicas y proyecciones en investigación
title_sort	purinas y ácido úrico en pre-eclampsia: interacciones fisiopatológicas y proyecciones en investigación
publisher	Sociedad Médica de Santiago
publishDate	2013
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872013000700009
work_keys_str_mv	AT escuderocarlos purinasyacidouricoenpreeclampsiainteraccionesfisiopatologicasyproyeccioneseninvestigacion AT bertogliapatricio purinasyacidouricoenpreeclampsiainteraccionesfisiopatologicasyproyeccioneseninvestigacion AT munozfelipe purinasyacidouricoenpreeclampsiainteraccionesfisiopatologicasyproyeccioneseninvestigacion AT robertsjamesm purinasyacidouricoenpreeclampsiainteraccionesfisiopatologicasyproyeccioneseninvestigacion
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Purinas y ácido úrico en pre-eclampsia: interacciones fisiopatológicas y proyecciones en investigación

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