Niveles séricos de alanino-aminotransferasa en población chilena: análisis de los resultados de la encuesta nacional de salud 2009-2010

Background: Determination of Alanine aminotransferase serum levels ([ALT]s) is a sensitive ana reliable test for liver diseases. Aim: To report the prevalence of abnormal [ALT]s in Chilean population and to identify associated variables. Methods: We analyzed data from a random sub-sample of 2,794 ad...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Tejos,Rodrigo, Padilla,Oslando, Pizarro,Margarita, Solís,Nancy, Arab,Juan Pablo, Margozzini,Paula, Miquel,Juan Francisco, Riquelme,Arnoldo, Arrese,Marco
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2013
Materias:	Alanine aminotransferase Hepatitis Hepatitis C virus Primary health care Secondary prevention fatty liver
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872013000700011
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:scielo:S0034-98872013000700011
record_format	dspace
spelling	oai:scielo:S0034-988720130007000112013-12-17Niveles séricos de alanino-aminotransferasa en población chilena: análisis de los resultados de la encuesta nacional de salud 2009-2010Tejos,RodrigoPadilla,OslandoPizarro,MargaritaSolís,NancyArab,Juan PabloMargozzini,PaulaMiquel,Juan FranciscoRiquelme,ArnoldoArrese,Marco Alanine aminotransferase Hepatitis Hepatitis C virus Primary health care Secondary prevention fatty liver Background: Determination of Alanine aminotransferase serum levels ([ALT]s) is a sensitive ana reliable test for liver diseases. Aim: To report the prevalence of abnormal [ALT]s in Chilean population and to identify associated variables. Methods: We analyzed data from a random sub-sample of 2,794 adults surveyed during the second Chilean National Health Survey. Abnormal [ALT]s were defined by using three different cut-off values (COV), two fixed COV (COV1: > 30 IU/L in men and > 19 IU/L in women and COV2 pre-defined by the performing laboratory) and a COV adjusted by age, weight and sex (COV3 > 31 IU/L for women and > 44 IU/L and men > 42 IU/L and > 66 IU/L with a BMI > 23). Logistic regression analysis was performed to determine risk factors for elevated [ALT]s Results: Mean [ALT]s values were 30.14 I U/L in men and 22.03 IU/L in women. The observed prevalence of abnormal [ALT]s defined by different COV were 38%, 11.5%, and 8.1% for COV1, COV2 and COV3 respectively. Variables independently associated to abnormal [ALT]s in a multivariate analysis were the following: serum gamma-glutamyl-transpeptidase (OR: 1.055 [95% CI 1.033-1.078]) and body mass index (OR:1.13 [95% CI 1.09-1.17]). Variables inversely associated with abnormal [ALT]s (COV1) were mole gender (OR-.0.976 [95% CI 0.96-0.99) and HDL-cholesterol (OR:0979 [95% CI 0.96-0.99]). Conclusions: Independently of the COV used, Chilean population exhibits a high prevalence of abnormal [ALT]s which may reflect a significant burden of liver disease. Non-alcoholic fatty liver disease could be a major contributor to elevated [ALT]s considering the association of abnormal [ALT]s and metabolic variables.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.141 n.7 20132013-07-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872013000700011es10.4067/S0034-98872013000700011
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Alanine aminotransferase Hepatitis Hepatitis C virus Primary health care Secondary prevention fatty liver
spellingShingle	Alanine aminotransferase Hepatitis Hepatitis C virus Primary health care Secondary prevention fatty liver Tejos,Rodrigo Padilla,Oslando Pizarro,Margarita Solís,Nancy Arab,Juan Pablo Margozzini,Paula Miquel,Juan Francisco Riquelme,Arnoldo Arrese,Marco Niveles séricos de alanino-aminotransferasa en población chilena: análisis de los resultados de la encuesta nacional de salud 2009-2010
description	Background: Determination of Alanine aminotransferase serum levels ([ALT]s) is a sensitive ana reliable test for liver diseases. Aim: To report the prevalence of abnormal [ALT]s in Chilean population and to identify associated variables. Methods: We analyzed data from a random sub-sample of 2,794 adults surveyed during the second Chilean National Health Survey. Abnormal [ALT]s were defined by using three different cut-off values (COV), two fixed COV (COV1: > 30 IU/L in men and > 19 IU/L in women and COV2 pre-defined by the performing laboratory) and a COV adjusted by age, weight and sex (COV3 > 31 IU/L for women and > 44 IU/L and men > 42 IU/L and > 66 IU/L with a BMI > 23). Logistic regression analysis was performed to determine risk factors for elevated [ALT]s Results: Mean [ALT]s values were 30.14 I U/L in men and 22.03 IU/L in women. The observed prevalence of abnormal [ALT]s defined by different COV were 38%, 11.5%, and 8.1% for COV1, COV2 and COV3 respectively. Variables independently associated to abnormal [ALT]s in a multivariate analysis were the following: serum gamma-glutamyl-transpeptidase (OR: 1.055 [95% CI 1.033-1.078]) and body mass index (OR:1.13 [95% CI 1.09-1.17]). Variables inversely associated with abnormal [ALT]s (COV1) were mole gender (OR-.0.976 [95% CI 0.96-0.99) and HDL-cholesterol (OR:0979 [95% CI 0.96-0.99]). Conclusions: Independently of the COV used, Chilean population exhibits a high prevalence of abnormal [ALT]s which may reflect a significant burden of liver disease. Non-alcoholic fatty liver disease could be a major contributor to elevated [ALT]s considering the association of abnormal [ALT]s and metabolic variables.
author	Tejos,Rodrigo Padilla,Oslando Pizarro,Margarita Solís,Nancy Arab,Juan Pablo Margozzini,Paula Miquel,Juan Francisco Riquelme,Arnoldo Arrese,Marco
author_facet	Tejos,Rodrigo Padilla,Oslando Pizarro,Margarita Solís,Nancy Arab,Juan Pablo Margozzini,Paula Miquel,Juan Francisco Riquelme,Arnoldo Arrese,Marco
author_sort	Tejos,Rodrigo
title	Niveles séricos de alanino-aminotransferasa en población chilena: análisis de los resultados de la encuesta nacional de salud 2009-2010
title_short	Niveles séricos de alanino-aminotransferasa en población chilena: análisis de los resultados de la encuesta nacional de salud 2009-2010
title_full	Niveles séricos de alanino-aminotransferasa en población chilena: análisis de los resultados de la encuesta nacional de salud 2009-2010
title_fullStr	Niveles séricos de alanino-aminotransferasa en población chilena: análisis de los resultados de la encuesta nacional de salud 2009-2010
title_full_unstemmed	Niveles séricos de alanino-aminotransferasa en población chilena: análisis de los resultados de la encuesta nacional de salud 2009-2010
title_sort	niveles séricos de alanino-aminotransferasa en población chilena: análisis de los resultados de la encuesta nacional de salud 2009-2010
publisher	Sociedad Médica de Santiago
publishDate	2013
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872013000700011
work_keys_str_mv	AT tejosrodrigo nivelessericosdealaninoaminotransferasaenpoblacionchilenaanalisisdelosresultadosdelaencuestanacionaldesalud20092010 AT padillaoslando nivelessericosdealaninoaminotransferasaenpoblacionchilenaanalisisdelosresultadosdelaencuestanacionaldesalud20092010 AT pizarromargarita nivelessericosdealaninoaminotransferasaenpoblacionchilenaanalisisdelosresultadosdelaencuestanacionaldesalud20092010 AT solisnancy nivelessericosdealaninoaminotransferasaenpoblacionchilenaanalisisdelosresultadosdelaencuestanacionaldesalud20092010 AT arabjuanpablo nivelessericosdealaninoaminotransferasaenpoblacionchilenaanalisisdelosresultadosdelaencuestanacionaldesalud20092010 AT margozzinipaula nivelessericosdealaninoaminotransferasaenpoblacionchilenaanalisisdelosresultadosdelaencuestanacionaldesalud20092010 AT miqueljuanfrancisco nivelessericosdealaninoaminotransferasaenpoblacionchilenaanalisisdelosresultadosdelaencuestanacionaldesalud20092010 AT riquelmearnoldo nivelessericosdealaninoaminotransferasaenpoblacionchilenaanalisisdelosresultadosdelaencuestanacionaldesalud20092010 AT arresemarco nivelessericosdealaninoaminotransferasaenpoblacionchilenaanalisisdelosresultadosdelaencuestanacionaldesalud20092010
_version_	1718436700878798848

Niveles séricos de alanino-aminotransferasa en población chilena: análisis de los resultados de la encuesta nacional de salud 2009-2010

Ejemplares similares