Bases epigenéticas del cáncer gástrico: oportunidades para la búsqueda de nuevos biomarcadores

Gastric cancer is the first cause of death for cancer in Chile. The recently identified genetic alterations in these tumors have not yielded new biomarkers for the disease. Epigenetics or the study of reversible genomic changes that do not affect protein codifying DNA sequences but cause phenotypic...

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Autor principal:	Corvalán R,Alejandro
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2013
Materias:	Biological markers Epigenomics Stomach neoplasms
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872013001200011
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spelling	oai:scielo:S0034-988720130012000112014-10-10Bases epigenéticas del cáncer gástrico: oportunidades para la búsqueda de nuevos biomarcadoresCorvalán R,Alejandro Biological markers Epigenomics Stomach neoplasms Gastric cancer is the first cause of death for cancer in Chile. The recently identified genetic alterations in these tumors have not yielded new biomarkers for the disease. Epigenetics or the study of reversible genomic changes that do not affect protein codifying DNA sequences but cause phenotypic disturbances, is identifying new cancer biomarkers. Specifically, the loss of expression caused by the covalent link of a methyl group to carbon 5 of cytosine (DNA hypermethylation) is extensively evaluated. Performing an epigenetic evaluation of 24 genes, we have identified eight genes associated to the aggressive signet ring cell type gastric cancer, the association between APC hypermethylation and worse prognosis and BRCA1 hypermethylation association with early onset of gastric cancer. The most interesting findings are the hypermethylation of Reprimo gene in plasma as a population biomarker and the tissue over expression of p73 gene (as a consequence of hypomethylation) as a high risk indicator of progression to gastric cancer. All these findings are indicating an important role of epigenetics in the pathogenesis and early detection of gastric cancer.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.141 n.12 20132013-12-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872013001200011es10.4067/S0034-98872013001200011
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Biological markers Epigenomics Stomach neoplasms
spellingShingle	Biological markers Epigenomics Stomach neoplasms Corvalán R,Alejandro Bases epigenéticas del cáncer gástrico: oportunidades para la búsqueda de nuevos biomarcadores
description	Gastric cancer is the first cause of death for cancer in Chile. The recently identified genetic alterations in these tumors have not yielded new biomarkers for the disease. Epigenetics or the study of reversible genomic changes that do not affect protein codifying DNA sequences but cause phenotypic disturbances, is identifying new cancer biomarkers. Specifically, the loss of expression caused by the covalent link of a methyl group to carbon 5 of cytosine (DNA hypermethylation) is extensively evaluated. Performing an epigenetic evaluation of 24 genes, we have identified eight genes associated to the aggressive signet ring cell type gastric cancer, the association between APC hypermethylation and worse prognosis and BRCA1 hypermethylation association with early onset of gastric cancer. The most interesting findings are the hypermethylation of Reprimo gene in plasma as a population biomarker and the tissue over expression of p73 gene (as a consequence of hypomethylation) as a high risk indicator of progression to gastric cancer. All these findings are indicating an important role of epigenetics in the pathogenesis and early detection of gastric cancer.
author	Corvalán R,Alejandro
author_facet	Corvalán R,Alejandro
author_sort	Corvalán R,Alejandro
title	Bases epigenéticas del cáncer gástrico: oportunidades para la búsqueda de nuevos biomarcadores
title_short	Bases epigenéticas del cáncer gástrico: oportunidades para la búsqueda de nuevos biomarcadores
title_full	Bases epigenéticas del cáncer gástrico: oportunidades para la búsqueda de nuevos biomarcadores
title_fullStr	Bases epigenéticas del cáncer gástrico: oportunidades para la búsqueda de nuevos biomarcadores
title_full_unstemmed	Bases epigenéticas del cáncer gástrico: oportunidades para la búsqueda de nuevos biomarcadores
title_sort	bases epigenéticas del cáncer gástrico: oportunidades para la búsqueda de nuevos biomarcadores
publisher	Sociedad Médica de Santiago
publishDate	2013
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872013001200011
work_keys_str_mv	AT corvalanralejandro basesepigeneticasdelcancergastricooportunidadesparalabusquedadenuevosbiomarcadores
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Bases epigenéticas del cáncer gástrico: oportunidades para la búsqueda de nuevos biomarcadores

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