Efecto de la ingesta de vitamina C en el proceso de formación de cálculos biliares de colesterol

Background: Biliary cholesterol is transported by vesicles and micelles. Cholesterol microcrystals are derived from thermodynamically unstable vesicles. In experimental animals vitamin C deficiency leads to a super-saturation of biliary cholesterol and to the formation of gallstones. Aim: To search...

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Autores principales:	del Pozo,Reginald, Muñoz,Mirna, Dumas,Andrés, Tapia,Claudio, Muñoz,Katia, Fuentes,Felipe, Maldonado,Mafalda, Jüngst,Dieter
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2014
Materias:	Ascorbic acid Cholesterol Phospholipids
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872014000100004
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spelling	oai:scielo:S0034-988720140001000042014-08-18Efecto de la ingesta de vitamina C en el proceso de formación de cálculos biliares de colesteroldel Pozo,ReginaldMuñoz,MirnaDumas,AndrésTapia,ClaudioMuñoz,KatiaFuentes,FelipeMaldonado,MafaldaJüngst,Dieter Ascorbic acid Cholesterol Phospholipids Background: Biliary cholesterol is transported by vesicles and micelles. Cholesterol microcrystals are derived from thermodynamically unstable vesicles. In experimental animals vitamin C deficiency leads to a super-saturation of biliary cholesterol and to the formation of gallstones. Aim: To search for a possible relationship between serum levels of vitamin C and the formation of cholesterol gallstones in patients with cholelithiasis. Material and Methods: Thirteen patients with cholelithiasis and a programmed surgical intervention were treated with 2 g/day of vitamin C per os for two weeks before surgery. Forty nine patients subjected to a cholecystectomy not supplemented with vitamin C were studied as controls. Plasma concentrations of vitamin C and lipid profiles were measured. The cholesterol saturation index, crystallization time, cholesterol and phospholipid content in vesicles and micelles, separated by gel filtration chromatography, were studied in bile samples obtained from the gallbladder. Results: Vitamin C supplementation did not change significantly plasma lipids and bile lipid concentrations. However, in supplemented patients, significant reductions in vesicular cholesterol content (6.5 ± 4.8% compared to 17.9 ± 14.0% in the control group; p < 0.05) and vesicular cholesterol/phospholipid ratio (0.71 ± 0.53 compared to 1.36 ± 1.15 in controls; p < 0.05), were observed. Conclusions: Vitamin C administration may modify bile cholesterol crystallization process, the first step in cholesterol gallstone formation.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.142 n.1 20142014-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872014000100004es10.4067/S0034-98872014000100004
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Ascorbic acid Cholesterol Phospholipids
spellingShingle	Ascorbic acid Cholesterol Phospholipids del Pozo,Reginald Muñoz,Mirna Dumas,Andrés Tapia,Claudio Muñoz,Katia Fuentes,Felipe Maldonado,Mafalda Jüngst,Dieter Efecto de la ingesta de vitamina C en el proceso de formación de cálculos biliares de colesterol
description	Background: Biliary cholesterol is transported by vesicles and micelles. Cholesterol microcrystals are derived from thermodynamically unstable vesicles. In experimental animals vitamin C deficiency leads to a super-saturation of biliary cholesterol and to the formation of gallstones. Aim: To search for a possible relationship between serum levels of vitamin C and the formation of cholesterol gallstones in patients with cholelithiasis. Material and Methods: Thirteen patients with cholelithiasis and a programmed surgical intervention were treated with 2 g/day of vitamin C per os for two weeks before surgery. Forty nine patients subjected to a cholecystectomy not supplemented with vitamin C were studied as controls. Plasma concentrations of vitamin C and lipid profiles were measured. The cholesterol saturation index, crystallization time, cholesterol and phospholipid content in vesicles and micelles, separated by gel filtration chromatography, were studied in bile samples obtained from the gallbladder. Results: Vitamin C supplementation did not change significantly plasma lipids and bile lipid concentrations. However, in supplemented patients, significant reductions in vesicular cholesterol content (6.5 ± 4.8% compared to 17.9 ± 14.0% in the control group; p < 0.05) and vesicular cholesterol/phospholipid ratio (0.71 ± 0.53 compared to 1.36 ± 1.15 in controls; p < 0.05), were observed. Conclusions: Vitamin C administration may modify bile cholesterol crystallization process, the first step in cholesterol gallstone formation.
author	del Pozo,Reginald Muñoz,Mirna Dumas,Andrés Tapia,Claudio Muñoz,Katia Fuentes,Felipe Maldonado,Mafalda Jüngst,Dieter
author_facet	del Pozo,Reginald Muñoz,Mirna Dumas,Andrés Tapia,Claudio Muñoz,Katia Fuentes,Felipe Maldonado,Mafalda Jüngst,Dieter
author_sort	del Pozo,Reginald
title	Efecto de la ingesta de vitamina C en el proceso de formación de cálculos biliares de colesterol
title_short	Efecto de la ingesta de vitamina C en el proceso de formación de cálculos biliares de colesterol
title_full	Efecto de la ingesta de vitamina C en el proceso de formación de cálculos biliares de colesterol
title_fullStr	Efecto de la ingesta de vitamina C en el proceso de formación de cálculos biliares de colesterol
title_full_unstemmed	Efecto de la ingesta de vitamina C en el proceso de formación de cálculos biliares de colesterol
title_sort	efecto de la ingesta de vitamina c en el proceso de formación de cálculos biliares de colesterol
publisher	Sociedad Médica de Santiago
publishDate	2014
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872014000100004
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Efecto de la ingesta de vitamina C en el proceso de formación de cálculos biliares de colesterol

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