Obesidad y cáncer: la tormenta perfecta

While some genetic factors may explain the development of cancer, its main causes are related to environmental exposure to carcinogenic agents as well as to the effect of determined lifestyles and habits. Several epidemiological studies have shown a consistent relation between obesity and cancer. In...

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Autores principales:	Sánchez R,César, Ibáñez,Carolina, Klaassen,Julieta
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2014
Materias:	Bariatric surgery Neoplasms second primary Obesity
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872014000200010
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spelling	oai:scielo:S0034-988720140002000102014-08-18Obesidad y cáncer: la tormenta perfectaSánchez R,CésarIbáñez,CarolinaKlaassen,Julieta Bariatric surgery Neoplasms second primary Obesity While some genetic factors may explain the development of cancer, its main causes are related to environmental exposure to carcinogenic agents as well as to the effect of determined lifestyles and habits. Several epidemiological studies have shown a consistent relation between obesity and cancer. In non smokers, obesity is the most relevant risk factor in the development of malignant tumors. There is a clear association between obesity and endometrial cancer, breast cancer in postmenopausal women, pancreatic, esophageal and colon cancer. Sexual steroids, insulin like growth factor axis and adipokines are the three main models to explain the biological basis for the obesity-cancer relationship. However, these models do not explain all the biological mechanisms that link obesity to cancer. There are other factors in play such as chronic inflammation, hypoxia and oxidative stress. Obesity may hamper the screening, diagnosis and treatment of some tumors, increasing mortality rates. Obesity prevention and management, therefore, may be the most important modifiable factor in reducing both incidence and mortality in cancer. New studies are required to quantify the effect of intentional weight reduction on the incidence and relapse of cancer. Considering the efficacy of bariatric surgery for weight reduction, it is an attractive model to study this link.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.142 n.2 20142014-02-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872014000200010es10.4067/S0034-98872014000200010
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Bariatric surgery Neoplasms second primary Obesity
spellingShingle	Bariatric surgery Neoplasms second primary Obesity Sánchez R,César Ibáñez,Carolina Klaassen,Julieta Obesidad y cáncer: la tormenta perfecta
description	While some genetic factors may explain the development of cancer, its main causes are related to environmental exposure to carcinogenic agents as well as to the effect of determined lifestyles and habits. Several epidemiological studies have shown a consistent relation between obesity and cancer. In non smokers, obesity is the most relevant risk factor in the development of malignant tumors. There is a clear association between obesity and endometrial cancer, breast cancer in postmenopausal women, pancreatic, esophageal and colon cancer. Sexual steroids, insulin like growth factor axis and adipokines are the three main models to explain the biological basis for the obesity-cancer relationship. However, these models do not explain all the biological mechanisms that link obesity to cancer. There are other factors in play such as chronic inflammation, hypoxia and oxidative stress. Obesity may hamper the screening, diagnosis and treatment of some tumors, increasing mortality rates. Obesity prevention and management, therefore, may be the most important modifiable factor in reducing both incidence and mortality in cancer. New studies are required to quantify the effect of intentional weight reduction on the incidence and relapse of cancer. Considering the efficacy of bariatric surgery for weight reduction, it is an attractive model to study this link.
author	Sánchez R,César Ibáñez,Carolina Klaassen,Julieta
author_facet	Sánchez R,César Ibáñez,Carolina Klaassen,Julieta
author_sort	Sánchez R,César
title	Obesidad y cáncer: la tormenta perfecta
title_short	Obesidad y cáncer: la tormenta perfecta
title_full	Obesidad y cáncer: la tormenta perfecta
title_fullStr	Obesidad y cáncer: la tormenta perfecta
title_full_unstemmed	Obesidad y cáncer: la tormenta perfecta
title_sort	obesidad y cáncer: la tormenta perfecta
publisher	Sociedad Médica de Santiago
publishDate	2014
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872014000200010
work_keys_str_mv	AT sanchezrcesar obesidadycancerlatormentaperfecta AT ibanezcarolina obesidadycancerlatormentaperfecta AT klaassenjulieta obesidadycancerlatormentaperfecta
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Obesidad y cáncer: la tormenta perfecta

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