Geografía génica de Chile: Distribución regional de los aportes genéticos americanos, europeos y africanos

Background: The geographical distribution of genes plays a key role in genetic epidemiology. The Chilean population has three major stem groups (Native American, European and African). Aim: To estimate the regional rate of American, European and African admixture of the Chilean population. Subjects...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Fuentes,Macarena, Pulgar,Iván, Gallo,Carla, Bortolini,María-Cátira, Canizales-Quinteros,Samuel, Bedoya,Gabriel, González-José,Rolando, Ruiz-Linares,Andrés, Rothhammer,Francisco
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2014
Materias:	American native continental ancestry group Chile Indians South American
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872014000300001
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:scielo:S0034-98872014000300001
record_format	dspace
spelling	oai:scielo:S0034-988720140003000012014-09-02Geografía génica de Chile: Distribución regional de los aportes genéticos americanos, europeos y africanosFuentes,MacarenaPulgar,IvánGallo,CarlaBortolini,María-CátiraCanizales-Quinteros,SamuelBedoya,GabrielGonzález-José,RolandoRuiz-Linares,AndrésRothhammer,Francisco American native continental ancestry group Chile Indians South American Background: The geographical distribution of genes plays a key role in genetic epidemiology. The Chilean population has three major stem groups (Native American, European and African). Aim: To estimate the regional rate of American, European and African admixture of the Chilean population. Subjects and Methods: Forty single nucleotide polymorphisms (SNP´s) which exhibit substantially different frequencies between Amerindian populations (ancestry-informative markers or AIM´s), were genotyped in a sample of 923 Chilean participants to estimate individual genetic ancestry. Results: The American, European and African individual average admixture estimates for the 15 Chilean Regions were relatively homogeneous and not statistically different. However, higher American components were found in northern and southern Chile and higher European components were found in central Chile. A negative correlation between African admixture and latitude was observed. On the average, American and European genetic contributions were similar and significantly higher than the African contribution. Weighted mean American, European and African genetic contributions of 44.34% ± 3 9%, 51.85% ± 5.44% and 3.81% ± 0.45%, were estimated. Fifty two percent of subjects harbor African genes. Individuals with Aymara and Mapuche surnames have an American admixture of 58.64% and 68.33%, respectively. Conclusions: Half of the Chilean population harbors African genes. Participants with Aymara and Mapuche surnames had a higher American genetic contribution than the general Chilean population. These results confirm the usefulness of surnames as a frst approximation to determine genetic ancestry.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.142 n.3 20142014-03-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872014000300001es10.4067/S0034-98872014000300001
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	American native continental ancestry group Chile Indians South American
spellingShingle	American native continental ancestry group Chile Indians South American Fuentes,Macarena Pulgar,Iván Gallo,Carla Bortolini,María-Cátira Canizales-Quinteros,Samuel Bedoya,Gabriel González-José,Rolando Ruiz-Linares,Andrés Rothhammer,Francisco Geografía génica de Chile: Distribución regional de los aportes genéticos americanos, europeos y africanos
description	Background: The geographical distribution of genes plays a key role in genetic epidemiology. The Chilean population has three major stem groups (Native American, European and African). Aim: To estimate the regional rate of American, European and African admixture of the Chilean population. Subjects and Methods: Forty single nucleotide polymorphisms (SNP´s) which exhibit substantially different frequencies between Amerindian populations (ancestry-informative markers or AIM´s), were genotyped in a sample of 923 Chilean participants to estimate individual genetic ancestry. Results: The American, European and African individual average admixture estimates for the 15 Chilean Regions were relatively homogeneous and not statistically different. However, higher American components were found in northern and southern Chile and higher European components were found in central Chile. A negative correlation between African admixture and latitude was observed. On the average, American and European genetic contributions were similar and significantly higher than the African contribution. Weighted mean American, European and African genetic contributions of 44.34% ± 3 9%, 51.85% ± 5.44% and 3.81% ± 0.45%, were estimated. Fifty two percent of subjects harbor African genes. Individuals with Aymara and Mapuche surnames have an American admixture of 58.64% and 68.33%, respectively. Conclusions: Half of the Chilean population harbors African genes. Participants with Aymara and Mapuche surnames had a higher American genetic contribution than the general Chilean population. These results confirm the usefulness of surnames as a frst approximation to determine genetic ancestry.
author	Fuentes,Macarena Pulgar,Iván Gallo,Carla Bortolini,María-Cátira Canizales-Quinteros,Samuel Bedoya,Gabriel González-José,Rolando Ruiz-Linares,Andrés Rothhammer,Francisco
author_facet	Fuentes,Macarena Pulgar,Iván Gallo,Carla Bortolini,María-Cátira Canizales-Quinteros,Samuel Bedoya,Gabriel González-José,Rolando Ruiz-Linares,Andrés Rothhammer,Francisco
author_sort	Fuentes,Macarena
title	Geografía génica de Chile: Distribución regional de los aportes genéticos americanos, europeos y africanos
title_short	Geografía génica de Chile: Distribución regional de los aportes genéticos americanos, europeos y africanos
title_full	Geografía génica de Chile: Distribución regional de los aportes genéticos americanos, europeos y africanos
title_fullStr	Geografía génica de Chile: Distribución regional de los aportes genéticos americanos, europeos y africanos
title_full_unstemmed	Geografía génica de Chile: Distribución regional de los aportes genéticos americanos, europeos y africanos
title_sort	geografía génica de chile: distribución regional de los aportes genéticos americanos, europeos y africanos
publisher	Sociedad Médica de Santiago
publishDate	2014
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872014000300001
work_keys_str_mv	AT fuentesmacarena geografiagenicadechiledistribucionregionaldelosaportesgeneticosamericanoseuropeosyafricanos AT pulgarivan geografiagenicadechiledistribucionregionaldelosaportesgeneticosamericanoseuropeosyafricanos AT gallocarla geografiagenicadechiledistribucionregionaldelosaportesgeneticosamericanoseuropeosyafricanos AT bortolinimariacatira geografiagenicadechiledistribucionregionaldelosaportesgeneticosamericanoseuropeosyafricanos AT canizalesquinterossamuel geografiagenicadechiledistribucionregionaldelosaportesgeneticosamericanoseuropeosyafricanos AT bedoyagabriel geografiagenicadechiledistribucionregionaldelosaportesgeneticosamericanoseuropeosyafricanos AT gonzalezjoserolando geografiagenicadechiledistribucionregionaldelosaportesgeneticosamericanoseuropeosyafricanos AT ruizlinaresandres geografiagenicadechiledistribucionregionaldelosaportesgeneticosamericanoseuropeosyafricanos AT rothhammerfrancisco geografiagenicadechiledistribucionregionaldelosaportesgeneticosamericanoseuropeosyafricanos
_version_	1718436741605490688

Geografía génica de Chile: Distribución regional de los aportes genéticos americanos, europeos y africanos

Ejemplares similares