Neurotoxicidad secundaria a metronidazol: un efecto adverso reversible. Caso clínico

Metronidazole can cause adverse effects both in the central and peripheral nervous system. We report a 34-year-old female who presented a reversible cerebellar syndrome and peripheral neuropathy as an adverse effect associated with the use of metronidazole. Brain magnetic resonance imaging (MRI) sho...

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Autores principales:	Retamal-Riquelme,Eva, Soto-San Martín,Hernán, Vallejos-Castro,José, Galdames-Poblete,Daniel
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2014
Materias:	Cerebellar diseases Metronidazole Peripheral Nervous System diseases
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872014000300015
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spelling	oai:scielo:S0034-988720140003000152014-09-02Neurotoxicidad secundaria a metronidazol: un efecto adverso reversible. Caso clínicoRetamal-Riquelme,EvaSoto-San Martín,HernánVallejos-Castro,JoséGaldames-Poblete,Daniel Cerebellar diseases Metronidazole Peripheral Nervous System diseases Metronidazole can cause adverse effects both in the central and peripheral nervous system. We report a 34-year-old female who presented a reversible cerebellar syndrome and peripheral neuropathy as an adverse effect associated with the use of metronidazole. Brain magnetic resonance imaging (MRI) showed hyperintense T2 and FLAIR bilateral symmetrical cerebellar lesions, without contrast enhancement or mass effect, isointense in diffusion-weighted imaging and hypointense in apparent diffusion coefficient sequences. Also, electrophysiological evaluation was consistent with axonal polyneuropathy. She had received metronidazole for a liver abscess during 49 days. After discontinuation of metronidazole, she had rapid regression of cerebellar symptoms and normalization of MRI, with subsequent disappearance of peripheral symptoms. The brain MRI, electromyography and nerve conduction studies performed at 35 months later showed complete resolution of the lesions. Although metronidazole neurotoxicity is a rare event, it must be borne in mind because the prognosis is usually favorable after stopping the drug.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.142 n.3 20142014-03-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872014000300015es10.4067/S0034-98872014000300015
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Cerebellar diseases Metronidazole Peripheral Nervous System diseases
spellingShingle	Cerebellar diseases Metronidazole Peripheral Nervous System diseases Retamal-Riquelme,Eva Soto-San Martín,Hernán Vallejos-Castro,José Galdames-Poblete,Daniel Neurotoxicidad secundaria a metronidazol: un efecto adverso reversible. Caso clínico
description	Metronidazole can cause adverse effects both in the central and peripheral nervous system. We report a 34-year-old female who presented a reversible cerebellar syndrome and peripheral neuropathy as an adverse effect associated with the use of metronidazole. Brain magnetic resonance imaging (MRI) showed hyperintense T2 and FLAIR bilateral symmetrical cerebellar lesions, without contrast enhancement or mass effect, isointense in diffusion-weighted imaging and hypointense in apparent diffusion coefficient sequences. Also, electrophysiological evaluation was consistent with axonal polyneuropathy. She had received metronidazole for a liver abscess during 49 days. After discontinuation of metronidazole, she had rapid regression of cerebellar symptoms and normalization of MRI, with subsequent disappearance of peripheral symptoms. The brain MRI, electromyography and nerve conduction studies performed at 35 months later showed complete resolution of the lesions. Although metronidazole neurotoxicity is a rare event, it must be borne in mind because the prognosis is usually favorable after stopping the drug.
author	Retamal-Riquelme,Eva Soto-San Martín,Hernán Vallejos-Castro,José Galdames-Poblete,Daniel
author_facet	Retamal-Riquelme,Eva Soto-San Martín,Hernán Vallejos-Castro,José Galdames-Poblete,Daniel
author_sort	Retamal-Riquelme,Eva
title	Neurotoxicidad secundaria a metronidazol: un efecto adverso reversible. Caso clínico
title_short	Neurotoxicidad secundaria a metronidazol: un efecto adverso reversible. Caso clínico
title_full	Neurotoxicidad secundaria a metronidazol: un efecto adverso reversible. Caso clínico
title_fullStr	Neurotoxicidad secundaria a metronidazol: un efecto adverso reversible. Caso clínico
title_full_unstemmed	Neurotoxicidad secundaria a metronidazol: un efecto adverso reversible. Caso clínico
title_sort	neurotoxicidad secundaria a metronidazol: un efecto adverso reversible. caso clínico
publisher	Sociedad Médica de Santiago
publishDate	2014
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872014000300015
work_keys_str_mv	AT retamalriquelmeeva neurotoxicidadsecundariaametronidazolunefectoadversoreversiblecasoclinico AT sotosanmartinhernan neurotoxicidadsecundariaametronidazolunefectoadversoreversiblecasoclinico AT vallejoscastrojose neurotoxicidadsecundariaametronidazolunefectoadversoreversiblecasoclinico AT galdamespobletedaniel neurotoxicidadsecundariaametronidazolunefectoadversoreversiblecasoclinico
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Neurotoxicidad secundaria a metronidazol: un efecto adverso reversible. Caso clínico

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