Esclerosis múltiple recurrente remitente en el sector público de salud de Chile: Descripción clínica de 314 pacientes

Background: Immunomodulatory drugs (IMD), Interferon β1a, β1 b and glatiramer acetate are available in the Chilean public health system since June 2008 for patients with relapsing-remitting multiple sclerosis (RR-MS). Diagnostic confirmation and programmed follow up of these patien...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Nogales-Gaete,Jorge, Aracena,Rodrigo, Cepeda-Zumaeta,Sergio, Eloiza,Claudio, Agurto,Paula, Díaz,Vannia, Labbé,Silvia, Martínez,Séfora, Flores,Jazmín, Araya,Casandra
Lenguaje:Spanish / Castilian
Publicado: Sociedad Médica de Santiago 2014
Materias:
Acceso en línea:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872014000500002
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:scielo:S0034-98872014000500002
record_format dspace
spelling oai:scielo:S0034-988720140005000022014-10-10Esclerosis múltiple recurrente remitente en el sector público de salud de Chile: Descripción clínica de 314 pacientesNogales-Gaete,JorgeAracena,RodrigoCepeda-Zumaeta,SergioEloiza,ClaudioAgurto,PaulaDíaz,VanniaLabbé,SilviaMartínez,SéforaFlores,JazmínAraya,Casandra Disease progression Immunomodulation Multiple Sclerosisi Relapsin-Remitting Background: Immunomodulatory drugs (IMD), Interferon β1a, β1 b and glatiramer acetate are available in the Chilean public health system since June 2008 for patients with relapsing-remitting multiple sclerosis (RR-MS). Diagnostic confirmation and programmed follow up of these patients is carried out at a public national reference center. Aim: To describe the epidemiological and clinical features of 314 patients evaluated in this center between 2008 and 2012. Patients and Methods: Review of clinical records, to obtain information about demographic background, medical history, expanded disability status scale of Kurtzke (EDSS), multiple sclerosis functional composite (MSfic), intensity fatigue scale of Krupp, Rao’s Brief Repeatable Battery of Neuropsychological Tests (BNR-R) and anxious-depressive manifestations using Hamilton and Beck questionnaires. Results: The ages of patients ranged from 12 to 63 years and 67% were women. The initial symptoms were sensory disturbances in 20%, motor alterations in 18% and optical neuritis in 16%. In 9% of patients, the disease began with several manifestations. The EDSS was 4 or less in 73% of patients and cognitive impairment was observed in 34%. Treatment failure during the first and second years, occurred in 23 and 26% of patients, respectively. Male gender, age under 40 and brainstem malfunction at the onset of disease, were predictive of treatment failure during the second year. Conclusions: The features of these patients are very similar to those reported abroad.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.142 n.5 20142014-05-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872014000500002es10.4067/S0034-98872014000500002
institution Scielo Chile
collection Scielo Chile
language Spanish / Castilian
topic Disease progression
Immunomodulation
Multiple Sclerosisi
Relapsin-Remitting
spellingShingle Disease progression
Immunomodulation
Multiple Sclerosisi
Relapsin-Remitting
Nogales-Gaete,Jorge
Aracena,Rodrigo
Cepeda-Zumaeta,Sergio
Eloiza,Claudio
Agurto,Paula
Díaz,Vannia
Labbé,Silvia
Martínez,Séfora
Flores,Jazmín
Araya,Casandra
Esclerosis múltiple recurrente remitente en el sector público de salud de Chile: Descripción clínica de 314 pacientes
description Background: Immunomodulatory drugs (IMD), Interferon β1a, β1 b and glatiramer acetate are available in the Chilean public health system since June 2008 for patients with relapsing-remitting multiple sclerosis (RR-MS). Diagnostic confirmation and programmed follow up of these patients is carried out at a public national reference center. Aim: To describe the epidemiological and clinical features of 314 patients evaluated in this center between 2008 and 2012. Patients and Methods: Review of clinical records, to obtain information about demographic background, medical history, expanded disability status scale of Kurtzke (EDSS), multiple sclerosis functional composite (MSfic), intensity fatigue scale of Krupp, Rao’s Brief Repeatable Battery of Neuropsychological Tests (BNR-R) and anxious-depressive manifestations using Hamilton and Beck questionnaires. Results: The ages of patients ranged from 12 to 63 years and 67% were women. The initial symptoms were sensory disturbances in 20%, motor alterations in 18% and optical neuritis in 16%. In 9% of patients, the disease began with several manifestations. The EDSS was 4 or less in 73% of patients and cognitive impairment was observed in 34%. Treatment failure during the first and second years, occurred in 23 and 26% of patients, respectively. Male gender, age under 40 and brainstem malfunction at the onset of disease, were predictive of treatment failure during the second year. Conclusions: The features of these patients are very similar to those reported abroad.
author Nogales-Gaete,Jorge
Aracena,Rodrigo
Cepeda-Zumaeta,Sergio
Eloiza,Claudio
Agurto,Paula
Díaz,Vannia
Labbé,Silvia
Martínez,Séfora
Flores,Jazmín
Araya,Casandra
author_facet Nogales-Gaete,Jorge
Aracena,Rodrigo
Cepeda-Zumaeta,Sergio
Eloiza,Claudio
Agurto,Paula
Díaz,Vannia
Labbé,Silvia
Martínez,Séfora
Flores,Jazmín
Araya,Casandra
author_sort Nogales-Gaete,Jorge
title Esclerosis múltiple recurrente remitente en el sector público de salud de Chile: Descripción clínica de 314 pacientes
title_short Esclerosis múltiple recurrente remitente en el sector público de salud de Chile: Descripción clínica de 314 pacientes
title_full Esclerosis múltiple recurrente remitente en el sector público de salud de Chile: Descripción clínica de 314 pacientes
title_fullStr Esclerosis múltiple recurrente remitente en el sector público de salud de Chile: Descripción clínica de 314 pacientes
title_full_unstemmed Esclerosis múltiple recurrente remitente en el sector público de salud de Chile: Descripción clínica de 314 pacientes
title_sort esclerosis múltiple recurrente remitente en el sector público de salud de chile: descripción clínica de 314 pacientes
publisher Sociedad Médica de Santiago
publishDate 2014
url http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872014000500002
work_keys_str_mv AT nogalesgaetejorge esclerosismultiplerecurrenteremitenteenelsectorpublicodesaluddechiledescripcionclinicade314pacientes
AT aracenarodrigo esclerosismultiplerecurrenteremitenteenelsectorpublicodesaluddechiledescripcionclinicade314pacientes
AT cepedazumaetasergio esclerosismultiplerecurrenteremitenteenelsectorpublicodesaluddechiledescripcionclinicade314pacientes
AT eloizaclaudio esclerosismultiplerecurrenteremitenteenelsectorpublicodesaluddechiledescripcionclinicade314pacientes
AT agurtopaula esclerosismultiplerecurrenteremitenteenelsectorpublicodesaluddechiledescripcionclinicade314pacientes
AT diazvannia esclerosismultiplerecurrenteremitenteenelsectorpublicodesaluddechiledescripcionclinicade314pacientes
AT labbesilvia esclerosismultiplerecurrenteremitenteenelsectorpublicodesaluddechiledescripcionclinicade314pacientes
AT martinezsefora esclerosismultiplerecurrenteremitenteenelsectorpublicodesaluddechiledescripcionclinicade314pacientes
AT floresjazmin esclerosismultiplerecurrenteremitenteenelsectorpublicodesaluddechiledescripcionclinicade314pacientes
AT arayacasandra esclerosismultiplerecurrenteremitenteenelsectorpublicodesaluddechiledescripcionclinicade314pacientes
_version_ 1718436753342201856