Asociación entre obesidad y cáncer de ovario

Obesity is a risk factor for cancer. Epidemiological evidences associate ovarian cancer with obesity. Epithelial ovarian cancer (EOC) is the most common type of ovarian cancer and accounts for a high rate of mortality. The association between ovarian cancer and obesity could be explained by molecula...

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Autores principales:	Valladares,Macarena, Corsini,Gino, Romero,Carmen
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2014
Materias:	Leptin Obesity Ovarian neoplasms
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872014000500007
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spelling	oai:scielo:S0034-988720140005000072014-10-10Asociación entre obesidad y cáncer de ovarioValladares,MacarenaCorsini,GinoRomero,Carmen Leptin Obesity Ovarian neoplasms Obesity is a risk factor for cancer. Epidemiological evidences associate ovarian cancer with obesity. Epithelial ovarian cancer (EOC) is the most common type of ovarian cancer and accounts for a high rate of mortality. The association between ovarian cancer and obesity could be explained by molecular factors secreted by adipose tissue such as leptin. In EOC, leptin increases cell proliferation and inhibits apoptosis. Additionally, adipose tissue synthesizes endogenous estrogens, which increase cell proliferation of epithelial ovarian cells. Also, obesity associated hyperinsulinism could increase ovarian estrogen secretion.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.142 n.5 20142014-05-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872014000500007es10.4067/S0034-98872014000500007
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Leptin Obesity Ovarian neoplasms
spellingShingle	Leptin Obesity Ovarian neoplasms Valladares,Macarena Corsini,Gino Romero,Carmen Asociación entre obesidad y cáncer de ovario
description	Obesity is a risk factor for cancer. Epidemiological evidences associate ovarian cancer with obesity. Epithelial ovarian cancer (EOC) is the most common type of ovarian cancer and accounts for a high rate of mortality. The association between ovarian cancer and obesity could be explained by molecular factors secreted by adipose tissue such as leptin. In EOC, leptin increases cell proliferation and inhibits apoptosis. Additionally, adipose tissue synthesizes endogenous estrogens, which increase cell proliferation of epithelial ovarian cells. Also, obesity associated hyperinsulinism could increase ovarian estrogen secretion.
author	Valladares,Macarena Corsini,Gino Romero,Carmen
author_facet	Valladares,Macarena Corsini,Gino Romero,Carmen
author_sort	Valladares,Macarena
title	Asociación entre obesidad y cáncer de ovario
title_short	Asociación entre obesidad y cáncer de ovario
title_full	Asociación entre obesidad y cáncer de ovario
title_fullStr	Asociación entre obesidad y cáncer de ovario
title_full_unstemmed	Asociación entre obesidad y cáncer de ovario
title_sort	asociación entre obesidad y cáncer de ovario
publisher	Sociedad Médica de Santiago
publishDate	2014
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872014000500007
work_keys_str_mv	AT valladaresmacarena asociacionentreobesidadycancerdeovario AT corsinigino asociacionentreobesidadycancerdeovario AT romerocarmen asociacionentreobesidadycancerdeovario
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Asociación entre obesidad y cáncer de ovario

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