Analisis crítico de dos revisiones sistemáticas: ¿Es útil el ácido fólico para prevenir eventos cardiovasculares en pacientes con enfermedad renal crónica terminal o avanzada?

Patients with chronic kidney disease have an increased cardiovascular risk. Several non-traditional factors have been showed to be associated with this risk, including hyperhomocysteinemia. The effects of reducing homocysteine levels with folic acid supplementation have been studied in a number of r...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Peña,José, Claro,Juan Carlos
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2014
Materias:	Chronic Evidence-Based Practice Folic Acid Hyperhomocysteinemia Renal Insufficiency Renal Dialysis
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872014000500013
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:scielo:S0034-98872014000500013
record_format	dspace
spelling	oai:scielo:S0034-988720140005000132014-10-10Analisis crítico de dos revisiones sistemáticas: ¿Es útil el ácido fólico para prevenir eventos cardiovasculares en pacientes con enfermedad renal crónica terminal o avanzada?Peña,JoséClaro,Juan Carlos Chronic Evidence-Based Practice Folic Acid Hyperhomocysteinemia Renal Insufficiency Renal Dialysis Patients with chronic kidney disease have an increased cardiovascular risk. Several non-traditional factors have been showed to be associated with this risk, including hyperhomocysteinemia. The effects of reducing homocysteine levels with folic acid supplementation have been studied in a number of randomized trials, with mixed results. In this article we critically appraise two systematic reviews providing disparate conclusions about this question and we summarize their main findings using the GRADE methodology. We conclude that there are methodological differences that may explain the mixed results in both systematic reviews. Folic acid supplementation does not reduce cardiovascular morbidity or mortality in patients with chronic kidney disease at any stage.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.142 n.5 20142014-05-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872014000500013es10.4067/S0034-98872014000500013
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Chronic Evidence-Based Practice Folic Acid Hyperhomocysteinemia Renal Insufficiency Renal Dialysis
spellingShingle	Chronic Evidence-Based Practice Folic Acid Hyperhomocysteinemia Renal Insufficiency Renal Dialysis Peña,José Claro,Juan Carlos Analisis crítico de dos revisiones sistemáticas: ¿Es útil el ácido fólico para prevenir eventos cardiovasculares en pacientes con enfermedad renal crónica terminal o avanzada?
description	Patients with chronic kidney disease have an increased cardiovascular risk. Several non-traditional factors have been showed to be associated with this risk, including hyperhomocysteinemia. The effects of reducing homocysteine levels with folic acid supplementation have been studied in a number of randomized trials, with mixed results. In this article we critically appraise two systematic reviews providing disparate conclusions about this question and we summarize their main findings using the GRADE methodology. We conclude that there are methodological differences that may explain the mixed results in both systematic reviews. Folic acid supplementation does not reduce cardiovascular morbidity or mortality in patients with chronic kidney disease at any stage.
author	Peña,José Claro,Juan Carlos
author_facet	Peña,José Claro,Juan Carlos
author_sort	Peña,José
title	Analisis crítico de dos revisiones sistemáticas: ¿Es útil el ácido fólico para prevenir eventos cardiovasculares en pacientes con enfermedad renal crónica terminal o avanzada?
title_short	Analisis crítico de dos revisiones sistemáticas: ¿Es útil el ácido fólico para prevenir eventos cardiovasculares en pacientes con enfermedad renal crónica terminal o avanzada?
title_full	Analisis crítico de dos revisiones sistemáticas: ¿Es útil el ácido fólico para prevenir eventos cardiovasculares en pacientes con enfermedad renal crónica terminal o avanzada?
title_fullStr	Analisis crítico de dos revisiones sistemáticas: ¿Es útil el ácido fólico para prevenir eventos cardiovasculares en pacientes con enfermedad renal crónica terminal o avanzada?
title_full_unstemmed	Analisis crítico de dos revisiones sistemáticas: ¿Es útil el ácido fólico para prevenir eventos cardiovasculares en pacientes con enfermedad renal crónica terminal o avanzada?
title_sort	analisis crítico de dos revisiones sistemáticas: ¿es útil el ácido fólico para prevenir eventos cardiovasculares en pacientes con enfermedad renal crónica terminal o avanzada?
publisher	Sociedad Médica de Santiago
publishDate	2014
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872014000500013
work_keys_str_mv	AT penajose analisiscriticodedosrevisionessistematicasesutilelacidofolicoparaprevenireventoscardiovascularesenpacientesconenfermedadrenalcronicaterminaloavanzada AT clarojuancarlos analisiscriticodedosrevisionessistematicasesutilelacidofolicoparaprevenireventoscardiovascularesenpacientesconenfermedadrenalcronicaterminaloavanzada
_version_	1718436756264583168

Analisis crítico de dos revisiones sistemáticas: ¿Es útil el ácido fólico para prevenir eventos cardiovasculares en pacientes con enfermedad renal crónica terminal o avanzada?

Ejemplares similares