Brown tumors of the femur and pelvis secondary to a parathyroid carcinoma: Report of one case

Brown tumors result from excess osteoclast activity and consist of collections of osteoclasts intermixed with fibrous tissue and poorly mineralized woven bone. They are secondary to hyperparathyroidism (HPT). Their incidence is higher in primary than in secondary hyperparathyroidism. We report a 69...

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Autores principales:	Radulescu,Dan, Chis,Bogdan, Donca,Valer, Münteanu,Valentin
Lenguaje:	English
Publicado:	Sociedad Médica de Santiago 2014
Materias:	Hypercalcemia Hyperparathyroidism Parathyroid neoplasms
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872014000700014
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spelling	oai:scielo:S0034-988720140007000142014-12-10Brown tumors of the femur and pelvis secondary to a parathyroid carcinoma: Report of one caseRadulescu,DanChis,BogdanDonca,ValerMünteanu,Valentin Hypercalcemia Hyperparathyroidism Parathyroid neoplasms Brown tumors result from excess osteoclast activity and consist of collections of osteoclasts intermixed with fibrous tissue and poorly mineralized woven bone. They are secondary to hyperparathyroidism (HPT). Their incidence is higher in primary than in secondary hyperparathyroidism. We report a 69 years-old male, admitted in a state of confusion, lethargy and bedridden, with a pathological fracture of the femur caused by a brown tumor. The laboratory examination revealed a hypercalcemia (8.85 mEq/L), with high levels of ionized Ca (5.48mEq/L), serum alkaline phosphatases (416 U/L) and serum parathormone (120 pg/mL). Ultrasound examination of the neck showed a large parathyroid tumor, probably corresponding to a carcinoma. A primary HPT was diagnosed. The patient was hydrated and high doses of diuretics and bisphosphonates were administered. After correction of serum calcium and neurologic symptoms, the patient was operated, performing an extensive resection of the tumor. The pathology report confirmed the diagnosis of parathyroid carcinoma.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.142 n.7 20142014-07-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872014000700014en10.4067/S0034-98872014000700014
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Hypercalcemia Hyperparathyroidism Parathyroid neoplasms
spellingShingle	Hypercalcemia Hyperparathyroidism Parathyroid neoplasms Radulescu,Dan Chis,Bogdan Donca,Valer Münteanu,Valentin Brown tumors of the femur and pelvis secondary to a parathyroid carcinoma: Report of one case
description	Brown tumors result from excess osteoclast activity and consist of collections of osteoclasts intermixed with fibrous tissue and poorly mineralized woven bone. They are secondary to hyperparathyroidism (HPT). Their incidence is higher in primary than in secondary hyperparathyroidism. We report a 69 years-old male, admitted in a state of confusion, lethargy and bedridden, with a pathological fracture of the femur caused by a brown tumor. The laboratory examination revealed a hypercalcemia (8.85 mEq/L), with high levels of ionized Ca (5.48mEq/L), serum alkaline phosphatases (416 U/L) and serum parathormone (120 pg/mL). Ultrasound examination of the neck showed a large parathyroid tumor, probably corresponding to a carcinoma. A primary HPT was diagnosed. The patient was hydrated and high doses of diuretics and bisphosphonates were administered. After correction of serum calcium and neurologic symptoms, the patient was operated, performing an extensive resection of the tumor. The pathology report confirmed the diagnosis of parathyroid carcinoma.
author	Radulescu,Dan Chis,Bogdan Donca,Valer Münteanu,Valentin
author_facet	Radulescu,Dan Chis,Bogdan Donca,Valer Münteanu,Valentin
author_sort	Radulescu,Dan
title	Brown tumors of the femur and pelvis secondary to a parathyroid carcinoma: Report of one case
title_short	Brown tumors of the femur and pelvis secondary to a parathyroid carcinoma: Report of one case
title_full	Brown tumors of the femur and pelvis secondary to a parathyroid carcinoma: Report of one case
title_fullStr	Brown tumors of the femur and pelvis secondary to a parathyroid carcinoma: Report of one case
title_full_unstemmed	Brown tumors of the femur and pelvis secondary to a parathyroid carcinoma: Report of one case
title_sort	brown tumors of the femur and pelvis secondary to a parathyroid carcinoma: report of one case
publisher	Sociedad Médica de Santiago
publishDate	2014
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872014000700014
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Brown tumors of the femur and pelvis secondary to a parathyroid carcinoma: Report of one case

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