Variables perinatales de recién nacidos de madres Aymara sugieren adaptación genética a la altura

Background: Studies performed in Andean populations living in high altitude, indicate that the reduced availability of oxygen could be associated to both a fetal growth retardation and a lower birth weight. These variables are predictive of morbidity and mortality during the first year of life. Aim:...

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Autores principales:	Pizarro-Ortiz,María, Barra,Rodrigo, Gajardo,Felipe, Fuentes-Guajardo,Macarena, Rothhammer,Francisco
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2014
Materias:	Attitude Environment Indians, South American Infant newborn
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872014000800002
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spelling	oai:scielo:S0034-988720140008000022014-12-12Variables perinatales de recién nacidos de madres Aymara sugieren adaptación genética a la alturaPizarro-Ortiz,MaríaBarra,RodrigoGajardo,FelipeFuentes-Guajardo,MacarenaRothhammer,Francisco Attitude Environment Indians, South American Infant newborn Background: Studies performed in Andean populations living in high altitude, indicate that the reduced availability of oxygen could be associated to both a fetal growth retardation and a lower birth weight. These variables are predictive of morbidity and mortality during the first year of life. Aim: To study perinatal variables of newborns of mothers living at contrasting altitudinal levels, harboring different degrees of Aymara ancestry. Subjects and Methods: Review of medical records of 5,295 women whose deliveries occurred between February 2004 and August 2010. Information was obtained on place of residence, grouped into two categories: coast (150 to 3,000 m) and high plateau (3,000 to 4,300 m), ancestry was estimated using number of Aymara surnames that were homologated to percentages of Amerindian admixture, gestational age, birth weight, height, head circumference and obstetric variables. Results: Gestational age showed a tendency to increase and birth weight, height and head circumference to decrease with altitude of residence. Only weight reached statistical significance. Women with Aymara ancestry gave birth to children with a significantly higher gestational age, weight and cranial circumference. Conclusions: Altitude of residence is related to a decrease in perinatal variables that proved to be less pronounced in newborns of mothers with a higher degree of Aymara ancestry. Results suggest a genetic adaptation to hypoxia that could be related to candidate genes linked to the capture, transport or utilization of oxygen.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.142 n.8 20142014-08-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872014000800002es10.4067/S0034-98872014000800002
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Attitude Environment Indians, South American Infant newborn
spellingShingle	Attitude Environment Indians, South American Infant newborn Pizarro-Ortiz,María Barra,Rodrigo Gajardo,Felipe Fuentes-Guajardo,Macarena Rothhammer,Francisco Variables perinatales de recién nacidos de madres Aymara sugieren adaptación genética a la altura
description	Background: Studies performed in Andean populations living in high altitude, indicate that the reduced availability of oxygen could be associated to both a fetal growth retardation and a lower birth weight. These variables are predictive of morbidity and mortality during the first year of life. Aim: To study perinatal variables of newborns of mothers living at contrasting altitudinal levels, harboring different degrees of Aymara ancestry. Subjects and Methods: Review of medical records of 5,295 women whose deliveries occurred between February 2004 and August 2010. Information was obtained on place of residence, grouped into two categories: coast (150 to 3,000 m) and high plateau (3,000 to 4,300 m), ancestry was estimated using number of Aymara surnames that were homologated to percentages of Amerindian admixture, gestational age, birth weight, height, head circumference and obstetric variables. Results: Gestational age showed a tendency to increase and birth weight, height and head circumference to decrease with altitude of residence. Only weight reached statistical significance. Women with Aymara ancestry gave birth to children with a significantly higher gestational age, weight and cranial circumference. Conclusions: Altitude of residence is related to a decrease in perinatal variables that proved to be less pronounced in newborns of mothers with a higher degree of Aymara ancestry. Results suggest a genetic adaptation to hypoxia that could be related to candidate genes linked to the capture, transport or utilization of oxygen.
author	Pizarro-Ortiz,María Barra,Rodrigo Gajardo,Felipe Fuentes-Guajardo,Macarena Rothhammer,Francisco
author_facet	Pizarro-Ortiz,María Barra,Rodrigo Gajardo,Felipe Fuentes-Guajardo,Macarena Rothhammer,Francisco
author_sort	Pizarro-Ortiz,María
title	Variables perinatales de recién nacidos de madres Aymara sugieren adaptación genética a la altura
title_short	Variables perinatales de recién nacidos de madres Aymara sugieren adaptación genética a la altura
title_full	Variables perinatales de recién nacidos de madres Aymara sugieren adaptación genética a la altura
title_fullStr	Variables perinatales de recién nacidos de madres Aymara sugieren adaptación genética a la altura
title_full_unstemmed	Variables perinatales de recién nacidos de madres Aymara sugieren adaptación genética a la altura
title_sort	variables perinatales de recién nacidos de madres aymara sugieren adaptación genética a la altura
publisher	Sociedad Médica de Santiago
publishDate	2014
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872014000800002
work_keys_str_mv	AT pizarroortizmaria variablesperinatalesdereciennacidosdemadresaymarasugierenadaptaciongeneticaalaaltura AT barrarodrigo variablesperinatalesdereciennacidosdemadresaymarasugierenadaptaciongeneticaalaaltura AT gajardofelipe variablesperinatalesdereciennacidosdemadresaymarasugierenadaptaciongeneticaalaaltura AT fuentesguajardomacarena variablesperinatalesdereciennacidosdemadresaymarasugierenadaptaciongeneticaalaaltura AT rothhammerfrancisco variablesperinatalesdereciennacidosdemadresaymarasugierenadaptaciongeneticaalaaltura
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Variables perinatales de recién nacidos de madres Aymara sugieren adaptación genética a la altura

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