Evaluación de la insulinemia post carga oral de glucosa como método diagnóstico de resistencia a la insulina

Background: In our country, the assessment of insulin resistance (IR) measuring serum insulin levels at 60 and 120 minutes after a 75 g oral glucose tolerance test (OGTT), is usual. However, there is no information about the distribution of serum insulin levels in the Chilean population. Aim: To ass...

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Autores principales:	Arancibia,Constanza, Galgani,José, Valderas,Juan P, Morales,Mauricio, Santos,José Luis, Pollak,Felipe
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2014
Materias:	Glucose tolerance test Hyperinsulinism Insulin resistance
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872014000900003
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spelling	oai:scielo:S0034-988720140009000032014-12-17Evaluación de la insulinemia post carga oral de glucosa como método diagnóstico de resistencia a la insulinaArancibia,ConstanzaGalgani,JoséValderas,Juan PMorales,MauricioSantos,José LuisPollak,Felipe Glucose tolerance test Hyperinsulinism Insulin resistance Background: In our country, the assessment of insulin resistance (IR) measuring serum insulin levels at 60 and 120 minutes after a 75 g oral glucose tolerance test (OGTT), is usual. However, there is no information about the distribution of serum insulin levels in the Chilean population. Aim: To assess the distribution of serum insulin levels at 60 and 120 minutes during OGTTs and suggest a statistical cut-off point to estimate the degree of IR. Material and Methods: Retrospective analysis of 1815 OGTTs performed in non-diabetic subjects aged between 18 and 75 years, at a university medical center. HOMA-IR (Homeostasis Model Assessment), insulin sensitivity index of Matsuda (ISI-Composite), and their correlation with serum insulin levels at 60 and 120 minutes were calculated. Results: The 75th percentiles for serum insulin levels at 60 and 120 minutes were 127 and 81 µU/mL, respectively. There was a high correlation between HOMA-IR and ISI-Composite (r = -089, p < 0.001). There was a weaker although significant correlation between HOMA-IR and ISI-Composite and insulin levels at 60 (r = 0.56 and -0.79 respectively, p < 0,001) and 120 minutes (r = 0.54 and -0.75 respectively, p < 0,001). Conclusions: We propose 60 and 120 min serum insulin levels of 130 and 80 µU/mL respectively, as cut-off values for normality during OGTT in Chilean normoglycemic individuals.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.142 n.9 20142014-09-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872014000900003es10.4067/S0034-98872014000900003
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Glucose tolerance test Hyperinsulinism Insulin resistance
spellingShingle	Glucose tolerance test Hyperinsulinism Insulin resistance Arancibia,Constanza Galgani,José Valderas,Juan P Morales,Mauricio Santos,José Luis Pollak,Felipe Evaluación de la insulinemia post carga oral de glucosa como método diagnóstico de resistencia a la insulina
description	Background: In our country, the assessment of insulin resistance (IR) measuring serum insulin levels at 60 and 120 minutes after a 75 g oral glucose tolerance test (OGTT), is usual. However, there is no information about the distribution of serum insulin levels in the Chilean population. Aim: To assess the distribution of serum insulin levels at 60 and 120 minutes during OGTTs and suggest a statistical cut-off point to estimate the degree of IR. Material and Methods: Retrospective analysis of 1815 OGTTs performed in non-diabetic subjects aged between 18 and 75 years, at a university medical center. HOMA-IR (Homeostasis Model Assessment), insulin sensitivity index of Matsuda (ISI-Composite), and their correlation with serum insulin levels at 60 and 120 minutes were calculated. Results: The 75th percentiles for serum insulin levels at 60 and 120 minutes were 127 and 81 µU/mL, respectively. There was a high correlation between HOMA-IR and ISI-Composite (r = -089, p < 0.001). There was a weaker although significant correlation between HOMA-IR and ISI-Composite and insulin levels at 60 (r = 0.56 and -0.79 respectively, p < 0,001) and 120 minutes (r = 0.54 and -0.75 respectively, p < 0,001). Conclusions: We propose 60 and 120 min serum insulin levels of 130 and 80 µU/mL respectively, as cut-off values for normality during OGTT in Chilean normoglycemic individuals.
author	Arancibia,Constanza Galgani,José Valderas,Juan P Morales,Mauricio Santos,José Luis Pollak,Felipe
author_facet	Arancibia,Constanza Galgani,José Valderas,Juan P Morales,Mauricio Santos,José Luis Pollak,Felipe
author_sort	Arancibia,Constanza
title	Evaluación de la insulinemia post carga oral de glucosa como método diagnóstico de resistencia a la insulina
title_short	Evaluación de la insulinemia post carga oral de glucosa como método diagnóstico de resistencia a la insulina
title_full	Evaluación de la insulinemia post carga oral de glucosa como método diagnóstico de resistencia a la insulina
title_fullStr	Evaluación de la insulinemia post carga oral de glucosa como método diagnóstico de resistencia a la insulina
title_full_unstemmed	Evaluación de la insulinemia post carga oral de glucosa como método diagnóstico de resistencia a la insulina
title_sort	evaluación de la insulinemia post carga oral de glucosa como método diagnóstico de resistencia a la insulina
publisher	Sociedad Médica de Santiago
publishDate	2014
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872014000900003
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Evaluación de la insulinemia post carga oral de glucosa como método diagnóstico de resistencia a la insulina

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