Genética, HLA-B27 y espondilitis anquilosante: 40 años

Ankylosing spondylitis (AS) is a prototypical inflammatory disease of the locomotor system affecting axial skeleton. It is part of the general group of spondyloarthopathies (SpA). Its strong association with histocompatibility antigen HLA-B27 is known since 1973. However, HLA-B27 contribution to AS...

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Autores principales:	Castro-Santos,Patricia, Gutiérrez,Miguel A, Díaz-Peña,Roberto
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2014
Materias:	Genetic predisposition to disease HLA-B27 antigen Spondylitis, ankylosing
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872014000900011
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spelling	oai:scielo:S0034-988720140009000112014-12-17Genética, HLA-B27 y espondilitis anquilosante: 40 añosCastro-Santos,PatriciaGutiérrez,Miguel ADíaz-Peña,Roberto Genetic predisposition to disease HLA-B27 antigen Spondylitis, ankylosing Ankylosing spondylitis (AS) is a prototypical inflammatory disease of the locomotor system affecting axial skeleton. It is part of the general group of spondyloarthopathies (SpA). Its strong association with histocompatibility antigen HLA-B27 is known since 1973. However, HLA-B27 contribution to AS genetic risk is approximately 16%. Therefore, other genes are necessarily involved in the pathogenesis of the disease. Genomic development and the possibility of making genome wide screening have contributed enormously to the study of the disease. In this paper, we describe the actual knowledge about AS genetic risk, which has contributed to understand the influence of HLA-B27 on the etiology and pathogenesis of the disease. We also intend to foresee how these findings will result in an improvement of patients quality of life.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.142 n.9 20142014-09-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872014000900011es10.4067/S0034-98872014000900011
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Genetic predisposition to disease HLA-B27 antigen Spondylitis, ankylosing
spellingShingle	Genetic predisposition to disease HLA-B27 antigen Spondylitis, ankylosing Castro-Santos,Patricia Gutiérrez,Miguel A Díaz-Peña,Roberto Genética, HLA-B27 y espondilitis anquilosante: 40 años
description	Ankylosing spondylitis (AS) is a prototypical inflammatory disease of the locomotor system affecting axial skeleton. It is part of the general group of spondyloarthopathies (SpA). Its strong association with histocompatibility antigen HLA-B27 is known since 1973. However, HLA-B27 contribution to AS genetic risk is approximately 16%. Therefore, other genes are necessarily involved in the pathogenesis of the disease. Genomic development and the possibility of making genome wide screening have contributed enormously to the study of the disease. In this paper, we describe the actual knowledge about AS genetic risk, which has contributed to understand the influence of HLA-B27 on the etiology and pathogenesis of the disease. We also intend to foresee how these findings will result in an improvement of patients quality of life.
author	Castro-Santos,Patricia Gutiérrez,Miguel A Díaz-Peña,Roberto
author_facet	Castro-Santos,Patricia Gutiérrez,Miguel A Díaz-Peña,Roberto
author_sort	Castro-Santos,Patricia
title	Genética, HLA-B27 y espondilitis anquilosante: 40 años
title_short	Genética, HLA-B27 y espondilitis anquilosante: 40 años
title_full	Genética, HLA-B27 y espondilitis anquilosante: 40 años
title_fullStr	Genética, HLA-B27 y espondilitis anquilosante: 40 años
title_full_unstemmed	Genética, HLA-B27 y espondilitis anquilosante: 40 años
title_sort	genética, hla-b27 y espondilitis anquilosante: 40 años
publisher	Sociedad Médica de Santiago
publishDate	2014
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872014000900011
work_keys_str_mv	AT castrosantospatricia geneticahlab27yespondilitisanquilosante40anos AT gutierrezmiguela geneticahlab27yespondilitisanquilosante40anos AT diazpenaroberto geneticahlab27yespondilitisanquilosante40anos
_version_	1718436777033728000

Genética, HLA-B27 y espondilitis anquilosante: 40 años

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