Cetoacidosis diabética: Casuística 2008-2012, epidemiología y fisiopatología
Background: During 2009, new guidelines for the treatment of diabetic ketoacidosis were published by the American Diabetes Association. Aim: To assess the impact of new treatment guidelines on the evolution of patients treated for diabetic ketoacidosis (KAD). Patients and Methods: Anonymous data was...
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Sociedad Médica de Santiago
2014
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oai:scielo:S0034-988720140010000062015-01-15Cetoacidosis diabética: Casuística 2008-2012, epidemiología y fisiopatologíaOlmos,PabloDonoso,AníbalArab,Juan PabloNiklitschek,IanMertens,NicolásArce,ElizabethLemus,RosarioSerrano,ValentinaGrassi,BrunoStrodthoff,KristelAbbott,EduardoAizman,AndrésGonzález,María Verónica Diabetes mellitus Diabetic Ketoacidosis Background: During 2009, new guidelines for the treatment of diabetic ketoacidosis were published by the American Diabetes Association. Aim: To assess the impact of new treatment guidelines on the evolution of patients treated for diabetic ketoacidosis (KAD). Patients and Methods: Anonymous data was obtained from computational medical records of patients treated for KAD at our institution two years before (“Traditional Protocol”) and TWO years after (“ADA-2009 Protocol”) the publication of the 2009 American Diabetes Association (ADA) KAD guidelines. Results: Twenty three patients aged 36.5 ± 15.1 years were treated with the traditional method and 23 patients aged 44.4 ± 21.1 years were treated following 2009 ADA guidelines. Among patients treated with the traditional protocol and treated following ADA 2009 guidelines, the diabetes type 1/type 2 ratio was18/5 and 19/16 respectively (p = NS), the glycosylated hemoglobin on admission was 12.6 ± 2.5 and 14.3 ± 2.7% respectively (p = 0.03), minimal blood pH was 7.15 ± 0.14 and 7.19 ± 0.09 respectively (p = NS), bicarbonate was required in seven and no patient respectively (p = 0.01), hypokalemia < 3.5 mEq/L occurred in 78.2 and 48.5% of patients (p = 0.03), the lapse until resolution was 28.7 ± 28.0 and 28.8 ± 20.6 hours (p = NS). Only one patient, treated following ADA 2009 guidelines, died. Conclusions: Introduction of the ADA-2009 protocol for the treatment of KAD resulted in decrease in the use of intravenous bicarbonate and a reduction in the incidence of hypokalemia. There was no impact neither in the lapse until resolution or lethality.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.142 n.10 20142014-10-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872014001000006es10.4067/S0034-98872014001000006 |
| institution |
Scielo Chile |
| collection |
Scielo Chile |
| language |
Spanish / Castilian |
| topic |
Diabetes mellitus Diabetic Ketoacidosis |
| spellingShingle |
Diabetes mellitus Diabetic Ketoacidosis Olmos,Pablo Donoso,Aníbal Arab,Juan Pablo Niklitschek,Ian Mertens,Nicolás Arce,Elizabeth Lemus,Rosario Serrano,Valentina Grassi,Bruno Strodthoff,Kristel Abbott,Eduardo Aizman,Andrés González,María Verónica Cetoacidosis diabética: Casuística 2008-2012, epidemiología y fisiopatología |
| description |
Background: During 2009, new guidelines for the treatment of diabetic ketoacidosis were published by the American Diabetes Association. Aim: To assess the impact of new treatment guidelines on the evolution of patients treated for diabetic ketoacidosis (KAD). Patients and Methods: Anonymous data was obtained from computational medical records of patients treated for KAD at our institution two years before (“Traditional Protocol”) and TWO years after (“ADA-2009 Protocol”) the publication of the 2009 American Diabetes Association (ADA) KAD guidelines. Results: Twenty three patients aged 36.5 ± 15.1 years were treated with the traditional method and 23 patients aged 44.4 ± 21.1 years were treated following 2009 ADA guidelines. Among patients treated with the traditional protocol and treated following ADA 2009 guidelines, the diabetes type 1/type 2 ratio was18/5 and 19/16 respectively (p = NS), the glycosylated hemoglobin on admission was 12.6 ± 2.5 and 14.3 ± 2.7% respectively (p = 0.03), minimal blood pH was 7.15 ± 0.14 and 7.19 ± 0.09 respectively (p = NS), bicarbonate was required in seven and no patient respectively (p = 0.01), hypokalemia < 3.5 mEq/L occurred in 78.2 and 48.5% of patients (p = 0.03), the lapse until resolution was 28.7 ± 28.0 and 28.8 ± 20.6 hours (p = NS). Only one patient, treated following ADA 2009 guidelines, died. Conclusions: Introduction of the ADA-2009 protocol for the treatment of KAD resulted in decrease in the use of intravenous bicarbonate and a reduction in the incidence of hypokalemia. There was no impact neither in the lapse until resolution or lethality. |
| author |
Olmos,Pablo Donoso,Aníbal Arab,Juan Pablo Niklitschek,Ian Mertens,Nicolás Arce,Elizabeth Lemus,Rosario Serrano,Valentina Grassi,Bruno Strodthoff,Kristel Abbott,Eduardo Aizman,Andrés González,María Verónica |
| author_facet |
Olmos,Pablo Donoso,Aníbal Arab,Juan Pablo Niklitschek,Ian Mertens,Nicolás Arce,Elizabeth Lemus,Rosario Serrano,Valentina Grassi,Bruno Strodthoff,Kristel Abbott,Eduardo Aizman,Andrés González,María Verónica |
| author_sort |
Olmos,Pablo |
| title |
Cetoacidosis diabética: Casuística 2008-2012, epidemiología y fisiopatología |
| title_short |
Cetoacidosis diabética: Casuística 2008-2012, epidemiología y fisiopatología |
| title_full |
Cetoacidosis diabética: Casuística 2008-2012, epidemiología y fisiopatología |
| title_fullStr |
Cetoacidosis diabética: Casuística 2008-2012, epidemiología y fisiopatología |
| title_full_unstemmed |
Cetoacidosis diabética: Casuística 2008-2012, epidemiología y fisiopatología |
| title_sort |
cetoacidosis diabética: casuística 2008-2012, epidemiología y fisiopatología |
| publisher |
Sociedad Médica de Santiago |
| publishDate |
2014 |
| url |
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872014001000006 |
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