Examen de detección de virus papiloma humano en el tamizaje de cáncer cervicouterino en un Servicio de Salud de Santiago, Chile

Background: Molecular techniques for human papillomavirus (HPV) detection have a good performance as screening tests and could be included in cervical cancer early detection programs. We conducted a population-based trial comparing HPV detection and Papanicolaou as primary screening tests, in a publ...

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Autores principales:	Terrazas,Solana, Ibáñez,Carolina, Lagos,Marcela, Poggi,Helena, Brañes,Jorge, Barriga,María Isabel, Cartagena,Jaime, Núñez,Felipe, González,Francisca, Cook,Paz, Van De Wyngard,Vanessa, Ferreccio,Catterina
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2015
Materias:	Chile DNA probes, HPV Papanicolaou test Uterine cervical neoplasms
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872015000100007
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spelling	oai:scielo:S0034-988720150001000072015-08-11Examen de detección de virus papiloma humano en el tamizaje de cáncer cervicouterino en un Servicio de Salud de Santiago, ChileTerrazas,SolanaIbáñez,CarolinaLagos,MarcelaPoggi,HelenaBrañes,JorgeBarriga,María IsabelCartagena,JaimeNúñez,FelipeGonzález,FranciscaCook,PazVan De Wyngard,VanessaFerreccio,Catterina Chile DNA probes, HPV Papanicolaou test Uterine cervical neoplasms Background: Molecular techniques for human papillomavirus (HPV) detection have a good performance as screening tests and could be included in cervical cancer early detection programs. We conducted a population-based trial comparing HPV detection and Papanicolaou as primary screening tests, in a public health service in Santiago, Chile. Aim: To describe the experience of implementing this new molecular test and present the main results of the study. Material and Methods: Women aged 25 to 64 enrolled in three public health centers were invited to participate. In all women, samples were collected for Papanicolaou and HPV DNA testing, and naked-eye visual inspection of the cervix with acetic acid was performed. Women with any positive screening test were referred to the local area hospital for diagnostic confirmation with colposcopy and biopsy of suspicious lesions. Results: Screening results were obtained for 8265 women, of whom 931 (11.3%) were positive to any test. The prevalence of cervical intraepithelial neoplasia grade 2 or worse (CIN2+) was 1.1%; nine women had invasive cervical cancer. Sensitivities for the detection of CIN2+ were 22.1% (95% confidence interval (CI) 16.4-29.2) for Papanicolaou and 92.7% (95% CI 84.4-96.8) for HPV testing; specificities were 98.9% (95% CI 98.7-99.0) and 92.0% (95% CI 91.4-92.6) respectively. Conclusion: This experience showed that the implementation of a molecular test for cervical cancer screening is not a major challenge in Chile: it was well accepted by both the health team and the participants, and it may improve the effectiveness of the screening program.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.143 n.1 20152015-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872015000100007es10.4067/S0034-98872015000100007
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Chile DNA probes, HPV Papanicolaou test Uterine cervical neoplasms
spellingShingle	Chile DNA probes, HPV Papanicolaou test Uterine cervical neoplasms Terrazas,Solana Ibáñez,Carolina Lagos,Marcela Poggi,Helena Brañes,Jorge Barriga,María Isabel Cartagena,Jaime Núñez,Felipe González,Francisca Cook,Paz Van De Wyngard,Vanessa Ferreccio,Catterina Examen de detección de virus papiloma humano en el tamizaje de cáncer cervicouterino en un Servicio de Salud de Santiago, Chile
description	Background: Molecular techniques for human papillomavirus (HPV) detection have a good performance as screening tests and could be included in cervical cancer early detection programs. We conducted a population-based trial comparing HPV detection and Papanicolaou as primary screening tests, in a public health service in Santiago, Chile. Aim: To describe the experience of implementing this new molecular test and present the main results of the study. Material and Methods: Women aged 25 to 64 enrolled in three public health centers were invited to participate. In all women, samples were collected for Papanicolaou and HPV DNA testing, and naked-eye visual inspection of the cervix with acetic acid was performed. Women with any positive screening test were referred to the local area hospital for diagnostic confirmation with colposcopy and biopsy of suspicious lesions. Results: Screening results were obtained for 8265 women, of whom 931 (11.3%) were positive to any test. The prevalence of cervical intraepithelial neoplasia grade 2 or worse (CIN2+) was 1.1%; nine women had invasive cervical cancer. Sensitivities for the detection of CIN2+ were 22.1% (95% confidence interval (CI) 16.4-29.2) for Papanicolaou and 92.7% (95% CI 84.4-96.8) for HPV testing; specificities were 98.9% (95% CI 98.7-99.0) and 92.0% (95% CI 91.4-92.6) respectively. Conclusion: This experience showed that the implementation of a molecular test for cervical cancer screening is not a major challenge in Chile: it was well accepted by both the health team and the participants, and it may improve the effectiveness of the screening program.
author	Terrazas,Solana Ibáñez,Carolina Lagos,Marcela Poggi,Helena Brañes,Jorge Barriga,María Isabel Cartagena,Jaime Núñez,Felipe González,Francisca Cook,Paz Van De Wyngard,Vanessa Ferreccio,Catterina
author_facet	Terrazas,Solana Ibáñez,Carolina Lagos,Marcela Poggi,Helena Brañes,Jorge Barriga,María Isabel Cartagena,Jaime Núñez,Felipe González,Francisca Cook,Paz Van De Wyngard,Vanessa Ferreccio,Catterina
author_sort	Terrazas,Solana
title	Examen de detección de virus papiloma humano en el tamizaje de cáncer cervicouterino en un Servicio de Salud de Santiago, Chile
title_short	Examen de detección de virus papiloma humano en el tamizaje de cáncer cervicouterino en un Servicio de Salud de Santiago, Chile
title_full	Examen de detección de virus papiloma humano en el tamizaje de cáncer cervicouterino en un Servicio de Salud de Santiago, Chile
title_fullStr	Examen de detección de virus papiloma humano en el tamizaje de cáncer cervicouterino en un Servicio de Salud de Santiago, Chile
title_full_unstemmed	Examen de detección de virus papiloma humano en el tamizaje de cáncer cervicouterino en un Servicio de Salud de Santiago, Chile
title_sort	examen de detección de virus papiloma humano en el tamizaje de cáncer cervicouterino en un servicio de salud de santiago, chile
publisher	Sociedad Médica de Santiago
publishDate	2015
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872015000100007
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Examen de detección de virus papiloma humano en el tamizaje de cáncer cervicouterino en un Servicio de Salud de Santiago, Chile

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