Estimadores de mezcla amerindia basados en métodos serológicos y moleculares

Background: Amerindian admixture is an important parameter to consider in epidemiological studies in American countries, to make a proper selection of cases and controls. Aim: To compare Amerindian admixture estimates obtained using ABO*A and ABO*O blood group alleles and ancestral identity markers...

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Autores principales:	Pulgar-Alarcón,Iván, Fuentes-Guajardo,Macarena, Llop,Elena, Rothhammer,Francisco
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2015
Materias:	American Native Continental Ancestry Group Chile, ABO Blood-Group System Indians, South American
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872015000400004
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spelling	oai:scielo:S0034-988720150004000042015-10-19Estimadores de mezcla amerindia basados en métodos serológicos y molecularesPulgar-Alarcón,IvánFuentes-Guajardo,MacarenaLlop,ElenaRothhammer,Francisco American Native Continental Ancestry Group Chile, ABO Blood-Group System Indians, South American Background: Amerindian admixture is an important parameter to consider in epidemiological studies in American countries, to make a proper selection of cases and controls. Aim: To compare Amerindian admixture estimates obtained using ABOA and ABOO blood group alleles and ancestral identity markers (AIMs) in the mixed Chilean population. Subjects and Methods: Amerindian admixture rates were determined in 720 Chilean volunteers residing in Arica and born in the 15 regions of the country, using ABOO and ABOA alleles and 40 AIMs selected from more than 500,000 single nucleotide polymorphisms (SNPs). Results: Mean admixture estimates obtained using ABOO and ABOA alleles and AIMs were 35, 47% and 48% respectively. There was concordance in estimates, with the exception of the admixture based on ABOO allele and AIMs. Conclusions: In Chile, Amerindian admixture estimates obtained using ABOA could be used as an alternative to AIMs in justified cases provided the sample size is reasonably large.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.143 n.4 20152015-04-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872015000400004es10.4067/S0034-98872015000400004
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	American Native Continental Ancestry Group Chile, ABO Blood-Group System Indians, South American
spellingShingle	American Native Continental Ancestry Group Chile, ABO Blood-Group System Indians, South American Pulgar-Alarcón,Iván Fuentes-Guajardo,Macarena Llop,Elena Rothhammer,Francisco Estimadores de mezcla amerindia basados en métodos serológicos y moleculares
description	Background: Amerindian admixture is an important parameter to consider in epidemiological studies in American countries, to make a proper selection of cases and controls. Aim: To compare Amerindian admixture estimates obtained using ABOA and ABOO blood group alleles and ancestral identity markers (AIMs) in the mixed Chilean population. Subjects and Methods: Amerindian admixture rates were determined in 720 Chilean volunteers residing in Arica and born in the 15 regions of the country, using ABOO and ABOA alleles and 40 AIMs selected from more than 500,000 single nucleotide polymorphisms (SNPs). Results: Mean admixture estimates obtained using ABOO and ABOA alleles and AIMs were 35, 47% and 48% respectively. There was concordance in estimates, with the exception of the admixture based on ABOO allele and AIMs. Conclusions: In Chile, Amerindian admixture estimates obtained using ABOA could be used as an alternative to AIMs in justified cases provided the sample size is reasonably large.
author	Pulgar-Alarcón,Iván Fuentes-Guajardo,Macarena Llop,Elena Rothhammer,Francisco
author_facet	Pulgar-Alarcón,Iván Fuentes-Guajardo,Macarena Llop,Elena Rothhammer,Francisco
author_sort	Pulgar-Alarcón,Iván
title	Estimadores de mezcla amerindia basados en métodos serológicos y moleculares
title_short	Estimadores de mezcla amerindia basados en métodos serológicos y moleculares
title_full	Estimadores de mezcla amerindia basados en métodos serológicos y moleculares
title_fullStr	Estimadores de mezcla amerindia basados en métodos serológicos y moleculares
title_full_unstemmed	Estimadores de mezcla amerindia basados en métodos serológicos y moleculares
title_sort	estimadores de mezcla amerindia basados en métodos serológicos y moleculares
publisher	Sociedad Médica de Santiago
publishDate	2015
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872015000400004
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Estimadores de mezcla amerindia basados en métodos serológicos y moleculares

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