Enfermedad inflamatoria intestinal en pacientes mayores de 60 años: ¿es una enfermedad diferente?

Background: Approximately, 15% of patients with Inflammatory Bowel Disease (IBD) are diagnosed at 60 years of age or more. Aim: To characterize and compare clinical variables between patients with IBD aged 60 years or more and their younger counterparts. Material and Methods: Retrospective study bas...

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Autores principales:	Simian,Daniela, Estay,Camila, Kronberg,Udo, Yarur,Andrés, Castro,Magdalena, Lubascher,Jaime, Acuña,Raúl, Quera,Rodrigo
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2015
Materias:	Aged Crohn Diseases Drug therapy Inflammatory Bowel Diseases Ulcerative Colitis
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872015000600001
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spelling	oai:scielo:S0034-988720150006000012015-10-19Enfermedad inflamatoria intestinal en pacientes mayores de 60 años: ¿es una enfermedad diferente?Simian,DanielaEstay,CamilaKronberg,UdoYarur,AndrésCastro,MagdalenaLubascher,JaimeAcuña,RaúlQuera,Rodrigo Aged Crohn Diseases Drug therapy Inflammatory Bowel Diseases Ulcerative Colitis Background: Approximately, 15% of patients with Inflammatory Bowel Disease (IBD) are diagnosed at 60 years of age or more. Aim: To characterize and compare clinical variables between patients with IBD aged 60 years or more and their younger counterparts. Material and Methods: Retrospective study based on a registry of IBD patients diagnosed between the years 1976 and 2014. Results: Four hundred and nine IBD patients were included. Among them, 294 had Ulcerative Colitis (UC), 104 had Crohn's Disease (CD) and eleven had an indeterminate IBD. Forty-six patients (11.2%) were older than 60 years and 16 (3.9%) had been diagnosed after this age. When comparing patients by age, those aged 60 years or more had a higher frequency of CD and indeterminate IBD (p < 0.01) and a lower ileocolic location in CD (p = 0.02). Both groups were similar in terms of hospitalization due to IBD flare, surgery, use of steroids, immunosuppressive or biological therapies and drug-related adverse events. When analyzing age at diagnosis of IBD, patients diagnosed at ages of 60 years or more had a lower frequency of UC (p < 0.01), a higher frequency of exclusive colonic involvement (p = 0.01), and lower use of mesalamine (p < 0.01). There were no differences in drug-related adverse events, hospitalizations due to IBD flares and surgery according to age at diagnosis. Conclusions: In this population, clinical features of IBD in older patients were similar to those in younger patients.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.143 n.6 20152015-06-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872015000600001es10.4067/S0034-98872015000600001
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Aged Crohn Diseases Drug therapy Inflammatory Bowel Diseases Ulcerative Colitis
spellingShingle	Aged Crohn Diseases Drug therapy Inflammatory Bowel Diseases Ulcerative Colitis Simian,Daniela Estay,Camila Kronberg,Udo Yarur,Andrés Castro,Magdalena Lubascher,Jaime Acuña,Raúl Quera,Rodrigo Enfermedad inflamatoria intestinal en pacientes mayores de 60 años: ¿es una enfermedad diferente?
description	Background: Approximately, 15% of patients with Inflammatory Bowel Disease (IBD) are diagnosed at 60 years of age or more. Aim: To characterize and compare clinical variables between patients with IBD aged 60 years or more and their younger counterparts. Material and Methods: Retrospective study based on a registry of IBD patients diagnosed between the years 1976 and 2014. Results: Four hundred and nine IBD patients were included. Among them, 294 had Ulcerative Colitis (UC), 104 had Crohn's Disease (CD) and eleven had an indeterminate IBD. Forty-six patients (11.2%) were older than 60 years and 16 (3.9%) had been diagnosed after this age. When comparing patients by age, those aged 60 years or more had a higher frequency of CD and indeterminate IBD (p < 0.01) and a lower ileocolic location in CD (p = 0.02). Both groups were similar in terms of hospitalization due to IBD flare, surgery, use of steroids, immunosuppressive or biological therapies and drug-related adverse events. When analyzing age at diagnosis of IBD, patients diagnosed at ages of 60 years or more had a lower frequency of UC (p < 0.01), a higher frequency of exclusive colonic involvement (p = 0.01), and lower use of mesalamine (p < 0.01). There were no differences in drug-related adverse events, hospitalizations due to IBD flares and surgery according to age at diagnosis. Conclusions: In this population, clinical features of IBD in older patients were similar to those in younger patients.
author	Simian,Daniela Estay,Camila Kronberg,Udo Yarur,Andrés Castro,Magdalena Lubascher,Jaime Acuña,Raúl Quera,Rodrigo
author_facet	Simian,Daniela Estay,Camila Kronberg,Udo Yarur,Andrés Castro,Magdalena Lubascher,Jaime Acuña,Raúl Quera,Rodrigo
author_sort	Simian,Daniela
title	Enfermedad inflamatoria intestinal en pacientes mayores de 60 años: ¿es una enfermedad diferente?
title_short	Enfermedad inflamatoria intestinal en pacientes mayores de 60 años: ¿es una enfermedad diferente?
title_full	Enfermedad inflamatoria intestinal en pacientes mayores de 60 años: ¿es una enfermedad diferente?
title_fullStr	Enfermedad inflamatoria intestinal en pacientes mayores de 60 años: ¿es una enfermedad diferente?
title_full_unstemmed	Enfermedad inflamatoria intestinal en pacientes mayores de 60 años: ¿es una enfermedad diferente?
title_sort	enfermedad inflamatoria intestinal en pacientes mayores de 60 años: ¿es una enfermedad diferente?
publisher	Sociedad Médica de Santiago
publishDate	2015
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872015000600001
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Enfermedad inflamatoria intestinal en pacientes mayores de 60 años: ¿es una enfermedad diferente?

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