Patrones de consumo y genotipos determinantes de la tolerancia al alcohol: estudio en estudiantes universitarios de Santiago de Chile
Background: Alleles involved in inefficient (ADH1B2*2 and ALDH2*2) or efficient (SNP6, ADH4 gene) alcohol metabolism may influence the risk of alcoholism. Alcoholism susceptibility has been classified as protector and risk-dependence phenotypes, associated with inefficient and efficient alcohol gene...
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Sociedad Médica de Santiago
2015
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oai:scielo:S0034-988720150006000032015-10-19Patrones de consumo y genotipos determinantes de la tolerancia al alcohol: estudio en estudiantes universitarios de Santiago de ChileSilva,Constanza PFlores,Sergio V Alcohol Dehydrogenase Alcohol Drinking Aldehyde Dehydrogenase Genetics, Population Genetic Variation Background: Alleles involved in inefficient (ADH1B2*2 and ALDH2*2) or efficient (SNP6, ADH4 gene) alcohol metabolism may influence the risk of alcoholism. Alcoholism susceptibility has been classified as protector and risk-dependence phenotypes, associated with inefficient and efficient alcohol genetic metabolizing variants, respectively. Aim: To investigate the possible association between genetic protective and risk-dependence variants and alcohol intake patterns. Material and Methods: Saliva DNA samples were obtained and the AUDIT (Alcohol Use Disorders Identification Test) questionnaire was applied to 210 university students aged between 18 and 25 years old. Results: No statistically significant association between protective or risk-dependence genetic variants and alcohol pattern intake was detected. However, new categories of alcohol intake patterns-not included in the AUDIT questionnaire-were identified. Conclusions: No association between the protector and risk-dependence phenotypes and patterns of alcohol consumption was detected in this sample of students.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.143 n.6 20152015-06-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872015000600003es10.4067/S0034-98872015000600003 |
| institution |
Scielo Chile |
| collection |
Scielo Chile |
| language |
Spanish / Castilian |
| topic |
Alcohol Dehydrogenase Alcohol Drinking Aldehyde Dehydrogenase Genetics, Population Genetic Variation |
| spellingShingle |
Alcohol Dehydrogenase Alcohol Drinking Aldehyde Dehydrogenase Genetics, Population Genetic Variation Silva,Constanza P Flores,Sergio V Patrones de consumo y genotipos determinantes de la tolerancia al alcohol: estudio en estudiantes universitarios de Santiago de Chile |
| description |
Background: Alleles involved in inefficient (ADH1B2*2 and ALDH2*2) or efficient (SNP6, ADH4 gene) alcohol metabolism may influence the risk of alcoholism. Alcoholism susceptibility has been classified as protector and risk-dependence phenotypes, associated with inefficient and efficient alcohol genetic metabolizing variants, respectively. Aim: To investigate the possible association between genetic protective and risk-dependence variants and alcohol intake patterns. Material and Methods: Saliva DNA samples were obtained and the AUDIT (Alcohol Use Disorders Identification Test) questionnaire was applied to 210 university students aged between 18 and 25 years old. Results: No statistically significant association between protective or risk-dependence genetic variants and alcohol pattern intake was detected. However, new categories of alcohol intake patterns-not included in the AUDIT questionnaire-were identified. Conclusions: No association between the protector and risk-dependence phenotypes and patterns of alcohol consumption was detected in this sample of students. |
| author |
Silva,Constanza P Flores,Sergio V |
| author_facet |
Silva,Constanza P Flores,Sergio V |
| author_sort |
Silva,Constanza P |
| title |
Patrones de consumo y genotipos determinantes de la tolerancia al alcohol: estudio en estudiantes universitarios de Santiago de Chile |
| title_short |
Patrones de consumo y genotipos determinantes de la tolerancia al alcohol: estudio en estudiantes universitarios de Santiago de Chile |
| title_full |
Patrones de consumo y genotipos determinantes de la tolerancia al alcohol: estudio en estudiantes universitarios de Santiago de Chile |
| title_fullStr |
Patrones de consumo y genotipos determinantes de la tolerancia al alcohol: estudio en estudiantes universitarios de Santiago de Chile |
| title_full_unstemmed |
Patrones de consumo y genotipos determinantes de la tolerancia al alcohol: estudio en estudiantes universitarios de Santiago de Chile |
| title_sort |
patrones de consumo y genotipos determinantes de la tolerancia al alcohol: estudio en estudiantes universitarios de santiago de chile |
| publisher |
Sociedad Médica de Santiago |
| publishDate |
2015 |
| url |
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872015000600003 |
| work_keys_str_mv |
AT silvaconstanzap patronesdeconsumoygenotiposdeterminantesdelatoleranciaalalcoholestudioenestudiantesuniversitariosdesantiagodechile AT floressergiov patronesdeconsumoygenotiposdeterminantesdelatoleranciaalalcoholestudioenestudiantesuniversitariosdesantiagodechile |
| _version_ |
1718436824975671296 |