Síndrome de hipoglicemia autoinmune: Primeros casos en Chile
Insulin autoimmune syndrome (IAS) is characterized by spontaneous hypoglycemia with extremely high insulin levels and the presence of circulating autoantibodies against insulin, in patients who have never been exposed to exogenous insulin. We report two patients with the syndrome. A 36 years old mal...
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Sociedad Médica de Santiago
2015
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oai:scielo:S0034-988720150007000162015-09-03Síndrome de hipoglicemia autoinmune: Primeros casos en ChileLanas,AlejandraParedes,AnaEspinosa,ConsueloCaamaño,EgardoPérez-Bravo,FranciscoPinto,RodrigoIñiguez,GermánMartínez,DaríoSoto,Néstor Autoimmune response Hypoglycemia Insulin antibodies Insulin autoimmune syndrome (IAS) is characterized by spontaneous hypoglycemia with extremely high insulin levels and the presence of circulating autoantibodies against insulin, in patients who have never been exposed to exogenous insulin. We report two patients with the syndrome. A 36 years old male presenting with hypoglycemia in the emergency room had an oral glucose tolerance test showed basal and 120 min glucose levels of 88 and 185 mg/dl. The basal and 120 min insulin levels were 2,759 and 5,942 μUI/ml. The presence of an insulin secreting tumor was discarded. Anti-insulin antibodies were positive. He was successfully treated with a diet restricted in carbohydrates and frequent meals in small quantities. A 65 years old female presenting with hypoglycemia in the emergency room had the fasting insulin levels of 1,910 µUI/ml. No insulin secreting tumor was detected by images and anti-insulin antibodies were positive. The polyethylene glycol precipitation test showed a basal and after exposition insulin level 1,483 and 114 µUI/ml, respectively. She responded partially to diet and acarbose and required the use of prednisone with a good clinical response.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.143 n.7 20152015-07-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872015000700016es10.4067/S0034-98872015000700016 |
| institution |
Scielo Chile |
| collection |
Scielo Chile |
| language |
Spanish / Castilian |
| topic |
Autoimmune response Hypoglycemia Insulin antibodies |
| spellingShingle |
Autoimmune response Hypoglycemia Insulin antibodies Lanas,Alejandra Paredes,Ana Espinosa,Consuelo Caamaño,Egardo Pérez-Bravo,Francisco Pinto,Rodrigo Iñiguez,Germán Martínez,Darío Soto,Néstor Síndrome de hipoglicemia autoinmune: Primeros casos en Chile |
| description |
Insulin autoimmune syndrome (IAS) is characterized by spontaneous hypoglycemia with extremely high insulin levels and the presence of circulating autoantibodies against insulin, in patients who have never been exposed to exogenous insulin. We report two patients with the syndrome. A 36 years old male presenting with hypoglycemia in the emergency room had an oral glucose tolerance test showed basal and 120 min glucose levels of 88 and 185 mg/dl. The basal and 120 min insulin levels were 2,759 and 5,942 μUI/ml. The presence of an insulin secreting tumor was discarded. Anti-insulin antibodies were positive. He was successfully treated with a diet restricted in carbohydrates and frequent meals in small quantities. A 65 years old female presenting with hypoglycemia in the emergency room had the fasting insulin levels of 1,910 µUI/ml. No insulin secreting tumor was detected by images and anti-insulin antibodies were positive. The polyethylene glycol precipitation test showed a basal and after exposition insulin level 1,483 and 114 µUI/ml, respectively. She responded partially to diet and acarbose and required the use of prednisone with a good clinical response. |
| author |
Lanas,Alejandra Paredes,Ana Espinosa,Consuelo Caamaño,Egardo Pérez-Bravo,Francisco Pinto,Rodrigo Iñiguez,Germán Martínez,Darío Soto,Néstor |
| author_facet |
Lanas,Alejandra Paredes,Ana Espinosa,Consuelo Caamaño,Egardo Pérez-Bravo,Francisco Pinto,Rodrigo Iñiguez,Germán Martínez,Darío Soto,Néstor |
| author_sort |
Lanas,Alejandra |
| title |
Síndrome de hipoglicemia autoinmune: Primeros casos en Chile |
| title_short |
Síndrome de hipoglicemia autoinmune: Primeros casos en Chile |
| title_full |
Síndrome de hipoglicemia autoinmune: Primeros casos en Chile |
| title_fullStr |
Síndrome de hipoglicemia autoinmune: Primeros casos en Chile |
| title_full_unstemmed |
Síndrome de hipoglicemia autoinmune: Primeros casos en Chile |
| title_sort |
síndrome de hipoglicemia autoinmune: primeros casos en chile |
| publisher |
Sociedad Médica de Santiago |
| publishDate |
2015 |
| url |
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872015000700016 |
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| _version_ |
1718436833390493696 |