Monitorización terapéutica de antibióticos: Nuevas metodologías: biosensores

The pharmacokinetics of antibiotics, especially in severely ill patients, may be profoundly altered due to multiple pathophysiological changes. Recent studies have shown that empiric dosing recommendations for ICU patients are inadequate to effectively treat a broad range of susceptible organisms an...

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Autores principales:	Soto,Dagoberto, Silva,Camila, Andresen V,Max, Soto,Natalia, Wong,Kwok-Yin, Andresen,Max
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2015
Materias:	Anti-bacterial agents Beta-Lactamase inhibitors Drug monitoring Fluorescein Pharmacokinetics
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872015000800013
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spelling	oai:scielo:S0034-988720150008000132015-10-01Monitorización terapéutica de antibióticos: Nuevas metodologías: biosensoresSoto,DagobertoSilva,CamilaAndresen V,MaxSoto,NataliaWong,Kwok-YinAndresen,Max Anti-bacterial agents Beta-Lactamase inhibitors Drug monitoring Fluorescein Pharmacokinetics The pharmacokinetics of antibiotics, especially in severely ill patients, may be profoundly altered due to multiple pathophysiological changes. Recent studies have shown that empiric dosing recommendations for ICU patients are inadequate to effectively treat a broad range of susceptible organisms and need to be reconsidered. Therapeutic drug monitoring (TDM) is an important mean for optimizing drug utilization and doses for the purpose of improving the clinical effectiveness. However, it is very challenging to quantify plasma antibiotic concentrations in clinical situations as a routine practice, because of the high costs and complexities associated with advanced instrumental techniques. Currently there are not routine and low cost methods to determine the presence and concentration of β-lactam antibiotics in plasma patients in a clinical setup. Indeed, such analytical methods are based on chromatographic techniques mainly used in research. Here we describe and comment different techniques, focusing on our preliminary experience using biosensors.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.143 n.8 20152015-08-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872015000800013es10.4067/S0034-98872015000800013
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Anti-bacterial agents Beta-Lactamase inhibitors Drug monitoring Fluorescein Pharmacokinetics
spellingShingle	Anti-bacterial agents Beta-Lactamase inhibitors Drug monitoring Fluorescein Pharmacokinetics Soto,Dagoberto Silva,Camila Andresen V,Max Soto,Natalia Wong,Kwok-Yin Andresen,Max Monitorización terapéutica de antibióticos: Nuevas metodologías: biosensores
description	The pharmacokinetics of antibiotics, especially in severely ill patients, may be profoundly altered due to multiple pathophysiological changes. Recent studies have shown that empiric dosing recommendations for ICU patients are inadequate to effectively treat a broad range of susceptible organisms and need to be reconsidered. Therapeutic drug monitoring (TDM) is an important mean for optimizing drug utilization and doses for the purpose of improving the clinical effectiveness. However, it is very challenging to quantify plasma antibiotic concentrations in clinical situations as a routine practice, because of the high costs and complexities associated with advanced instrumental techniques. Currently there are not routine and low cost methods to determine the presence and concentration of β-lactam antibiotics in plasma patients in a clinical setup. Indeed, such analytical methods are based on chromatographic techniques mainly used in research. Here we describe and comment different techniques, focusing on our preliminary experience using biosensors.
author	Soto,Dagoberto Silva,Camila Andresen V,Max Soto,Natalia Wong,Kwok-Yin Andresen,Max
author_facet	Soto,Dagoberto Silva,Camila Andresen V,Max Soto,Natalia Wong,Kwok-Yin Andresen,Max
author_sort	Soto,Dagoberto
title	Monitorización terapéutica de antibióticos: Nuevas metodologías: biosensores
title_short	Monitorización terapéutica de antibióticos: Nuevas metodologías: biosensores
title_full	Monitorización terapéutica de antibióticos: Nuevas metodologías: biosensores
title_fullStr	Monitorización terapéutica de antibióticos: Nuevas metodologías: biosensores
title_full_unstemmed	Monitorización terapéutica de antibióticos: Nuevas metodologías: biosensores
title_sort	monitorización terapéutica de antibióticos: nuevas metodologías: biosensores
publisher	Sociedad Médica de Santiago
publishDate	2015
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872015000800013
work_keys_str_mv	AT sotodagoberto monitorizacionterapeuticadeantibioticosnuevasmetodologiasbiosensores AT silvacamila monitorizacionterapeuticadeantibioticosnuevasmetodologiasbiosensores AT andresenvmax monitorizacionterapeuticadeantibioticosnuevasmetodologiasbiosensores AT sotonatalia monitorizacionterapeuticadeantibioticosnuevasmetodologiasbiosensores AT wongkwokyin monitorizacionterapeuticadeantibioticosnuevasmetodologiasbiosensores AT andresenmax monitorizacionterapeuticadeantibioticosnuevasmetodologiasbiosensores
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Monitorización terapéutica de antibióticos: Nuevas metodologías: biosensores

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