Efectores celulares de la respuesta inflamatoria en la enfermedad pulmonar obstructiva crónica

Approximately 3 million people in the world die every year as a consequence of COPD, which is associated with an abnormal inflammatory response of the lung to noxious particles and gases. This inflammatory pattern causes pathological changes leading to a narrowing of small airways and destruction of...

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Autores principales:	Silva O,Rafael, Montes,Juan F, García-Valero,José, Olloquequi,Jordi
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2015
Materias:	Emphysema Immunity Inflammation Leukocytes Pulmonary disease, chronic obstructive
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872015000900009
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spelling	oai:scielo:S0034-988720150009000092015-10-22Efectores celulares de la respuesta inflamatoria en la enfermedad pulmonar obstructiva crónicaSilva O,RafaelMontes,Juan FGarcía-Valero,JoséOlloquequi,Jordi Emphysema Immunity Inflammation Leukocytes Pulmonary disease, chronic obstructive Approximately 3 million people in the world die every year as a consequence of COPD, which is associated with an abnormal inflammatory response of the lung to noxious particles and gases. This inflammatory pattern causes pathological changes leading to a narrowing of small airways and destruction of lung parenchyma, also known as emphysema. Classically, these changes were associated to macrophages and neutrophils, although T CD8+ lymphocytes were latter added to the equation to explain the origin of emphysematous lesions. However, in recent years, multiple evidences have arisen indicating that inflammatory response in COPD is much more complex. These findings point to a key role for mast cells, dendritic cells, T CD4+ and B cells. The aim of this article is to review such evidence and report what is known so far about those cells involved in the inflammatory response in COPD.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.143 n.9 20152015-09-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872015000900009es10.4067/S0034-98872015000900009
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Emphysema Immunity Inflammation Leukocytes Pulmonary disease, chronic obstructive
spellingShingle	Emphysema Immunity Inflammation Leukocytes Pulmonary disease, chronic obstructive Silva O,Rafael Montes,Juan F García-Valero,José Olloquequi,Jordi Efectores celulares de la respuesta inflamatoria en la enfermedad pulmonar obstructiva crónica
description	Approximately 3 million people in the world die every year as a consequence of COPD, which is associated with an abnormal inflammatory response of the lung to noxious particles and gases. This inflammatory pattern causes pathological changes leading to a narrowing of small airways and destruction of lung parenchyma, also known as emphysema. Classically, these changes were associated to macrophages and neutrophils, although T CD8+ lymphocytes were latter added to the equation to explain the origin of emphysematous lesions. However, in recent years, multiple evidences have arisen indicating that inflammatory response in COPD is much more complex. These findings point to a key role for mast cells, dendritic cells, T CD4+ and B cells. The aim of this article is to review such evidence and report what is known so far about those cells involved in the inflammatory response in COPD.
author	Silva O,Rafael Montes,Juan F García-Valero,José Olloquequi,Jordi
author_facet	Silva O,Rafael Montes,Juan F García-Valero,José Olloquequi,Jordi
author_sort	Silva O,Rafael
title	Efectores celulares de la respuesta inflamatoria en la enfermedad pulmonar obstructiva crónica
title_short	Efectores celulares de la respuesta inflamatoria en la enfermedad pulmonar obstructiva crónica
title_full	Efectores celulares de la respuesta inflamatoria en la enfermedad pulmonar obstructiva crónica
title_fullStr	Efectores celulares de la respuesta inflamatoria en la enfermedad pulmonar obstructiva crónica
title_full_unstemmed	Efectores celulares de la respuesta inflamatoria en la enfermedad pulmonar obstructiva crónica
title_sort	efectores celulares de la respuesta inflamatoria en la enfermedad pulmonar obstructiva crónica
publisher	Sociedad Médica de Santiago
publishDate	2015
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872015000900009
work_keys_str_mv	AT silvaorafael efectorescelularesdelarespuestainflamatoriaenlaenfermedadpulmonarobstructivacronica AT montesjuanf efectorescelularesdelarespuestainflamatoriaenlaenfermedadpulmonarobstructivacronica AT garciavalerojose efectorescelularesdelarespuestainflamatoriaenlaenfermedadpulmonarobstructivacronica AT olloquequijordi efectorescelularesdelarespuestainflamatoriaenlaenfermedadpulmonarobstructivacronica
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Efectores celulares de la respuesta inflamatoria en la enfermedad pulmonar obstructiva crónica

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